由於硫化銅奈米材料具有良好的生物相容性、很好的光熱穩定性且價格便宜等特性，近年來相關的研究漸漸受到重視，然而將硫化銅與磁性奈米材料結合之相關文獻報導，卻相對稀少。在本篇研究中，將具有磁性之性質的四氧化三鐵磁性奈米粒子作為核心，在其表面先包覆上氧化亞銅殼層，形成四氧化三鐵－氧化亞銅核－殼奈米結構作為犧牲模板，再經由非典型的克肯達效應 (modified-Kirkendall effect)，將氧離子置換成硫離子，進而形成具有診斷與治療雙功能的四氧化三鐵－硫化銅蛋黃－蛋殼奈米結構，並在其表面修飾上聚乙二醇 (poly(ethylene glycol), PEG)，以進一步增加生物相容性與分散性。由於該材料以四氧化三鐵磁性奈米粒子作為核心，因此具有鐵磁性之性質，且其可作為磁共振造影之T2負相顯影試劑。此外由於該材料之殼層為具有光熱轉換性質的硫化銅奈米結構，因此其在近紅外光的吸收波段同時涵蓋了650-950 nm的第一生物視窗 (first NIR window) 與1000-1350 nm的第二生物視窗 (second NIR window) 之範圍，並透過1064 nm與808 nm近紅外光雷射之比較，得知該材料照射1064 nm近紅外光雷射有較佳的光熱治療之功效，並結合磁導引之應用，得到更佳的光熱治療之效果。最後，由於四氧化三鐵－硫化銅蛋黃－蛋殼奈米材料具備有優異的磁性與光學之性質，因此預期該材料在癌症的治療上會有良好的治療與診斷之功效。

Recently, research and application in copper sulfide nanomaterial have attracted much attention base on its biocompatibility, photostability, favourable price and etc. However, nanoparticles combined the copper sulfide with magnetic iron oxide nanoparticles are little reported in previous literatures. Herein, the yolk-shell Fe3O4@CuS nanoparticles were fabricated from core-shell Fe3O4@Cu2O nanoparticles via ion exchange pathway, which can be developed as a theranostic platform in cancer treatment. Due to the component of Fe3O4 core which provides ferromagnetic property, it can be applied as T2-negative contrast agents of magnetic resonance imaging (MRI). On the other hand, shell of the CuS nanomaterials provides the photothermal conversion properties. Therefore, the Fe3O4@CuS nanostructures exhibit significant near-infrared (NIR) absorption which cover the range of the first NIR window (650-950 nm) and second NIR window (1000-1350 nm). To compare excitation by 1064 nm and 808 nm NIR laser, the nanomaterial exhibits better efficiency of photothermal therapy by irradiated with 1064 nm than 808 nm NIR laser. Besides, magnetic targeting can enhance the efficiency of photothermal therapy. In conclusion, Fe3O4@CuS yolk-shell nanostructure provides the excellent magnetic and optical properties, it will be expected that there will be a promising theranostic platform in cancer treatment.

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