簡易檢索 / 詳目顯示

研究生: 黃貞怡
Huang, Chen-Yi
論文名稱: 以胸大肌變形技術估算乳房容積
Breast Volume Estimation Using Pectoralis Major Mapping Techniques
指導教授: 方晶晶
Fang, Jing-Jing
學位類別: 碩士
Master
系所名稱: 工學院 - 機械工程學系
Department of Mechanical Engineering
論文出版年: 2023
畢業學年度: 112
語文別: 中文
論文頁數: 120
中文關鍵詞: 乳房重建電腦斷層影像乳房容積估算
外文關鍵詞: Breast reconstruction, Computed tomography imaging, Breast volume estimation
相關次數: 點閱:144下載:21
分享至:
查詢本校圖書館目錄 查詢臺灣博碩士論文知識加值系統 勘誤回報
  • 隨著國人生活型態改變及飲食習慣西化,乳癌罹患率逐漸上升,目前乳癌的發生率為國內女性癌症的首位,以外科手術治療乳癌的方式,會依據乳癌擴散程度以及乳癌的種類,搭配不同術式切除乳房,然而,切除意味著乳房組織結構遭到破壞,使得乳房外形產生變化。患者可以藉由術中或術後接受乳房重建手術,在掌握乳房容積下,醫師能移植等容積量的皮瓣或是義乳,回復患者原有的乳房外形。
    目前最準確估測乳房容積的方法是透過能掌握在體內的乳房分布位置的CT與MRI影像,藉由手動繪製或是利用機器學習找出影像中的乳房區域,計算出影像中的乳房容積,然而,該方法受限於醫學影像儀器普及率低、單次拍攝費用高昂等限制,並非所有患者都會進行拍攝。近年來三維掃描技術興起,掃描影像由電腦軟體轉換後,立體地呈現在螢幕中,相較於醫學影像儀器,三維掃描器輕巧、機動性高,因此本研究提出了三維掃描技術與醫學影像相結合用於估算乳房容積的創新性方法。
    本研究以醫學影像建置包含胸骨(Sternum)、肋骨(Ribs)與胸大肌(Pectoralis Major, pecs)的乳下基底數位模型(Base),並生成基底數位模型資料庫,將患者的體表掃描匯入至本研究自行開發BVE軟體中,BVE軟體會從基底數位模型庫中選擇一基底數位模型,基底數位模型依據胸大肌變形技術變形後,以推估出的患者胸大肌前側表面作為乳房的基底面,在掌握患者內部結構後,軟體便能自動地估算出患者乳房容積。
    本研究以BVE軟體分割受試者乳房容積作為參考基準,檢驗受試者體表套用採用胸大肌變形技術變形的非受試者基底數位模型後估算出的乳房容積,其平均誤差絕對值超過25cm3,未達到理想乳房容積評估技術的準確度。採用胸大肌變形技術估算乳房容積的準確度仍待改進。

    The primary method of treating breast cancer is through surgical intervention, where the breast is removed based on the extent and type of cancer. However, this removal results in the disruption of breast tissue structure, leading to changes in breast appearance. Individual undergoes breast reconstruction surgery either during or after the procedure. Doctors restore the individual’s original breast shape by manipulating breast volume through techniques like flap transplantation or implanting prosthetic breasts.
    The most accurate method for estimating breast volume currently involves utilizing CT and MRI images that can capture the distribution of breast tissue within the body. By delineating the breast region in these images, the volume can be calculated. However, this method is constrained by factors such as the low prevalence of medical imaging equipment and the high cost of single scans, making it impractical for all individuals. In recent years, 3D scanning technology has emerged, allowing scanned images to be presented in three dimensions on a screen after conversion by computer software. Compared to medical imaging instruments, 3D scanners are lightweight and highly mobile. Therefore, this study proposes an innovative method for estimating breast volume by combining 3D scanning technology with the concept of medical imaging.
    In this study, a digital base model was constructed by medical imaging, including the sternum, ribs, and pectoralis major muscle. A database of these digital base models was generated. The torso of the individual’s scanned body was imported into the software developed for this study. The software automatically applied the pectoralis major mapping techniques and estimated the individual’s internal structure. The front torso of the pectoralis major was used as the base torso for the breast, and the preoperative breast volume of the individual was automatically estimated.
    The BVE software was used to segment the breast volume of the individual as a reference standard. The estimated breast volume of non-individual, based on the digital base model using the pectoralis major deformation technique, was examined. The average absolute error exceeded 25 cm3, falling to achieve the accuracy of ideal breast volume assessment techniques. The accuracy of using the pectoralis major mapping technique to estimate breast volume still requires improvement.

    摘要i 致謝vi 目錄vii 表目錄x 圖目錄xii 第一章 前言1 1.1 研究背景1 1.2 研究動機與目的2 1.3 本文架構4 第二章 文獻回顧5 2.1 乳房解剖學5 2.2 乳癌治療方法6 2.2.1 乳房切除術(Mastectomy)7 2.2.2 乳房重建手術9 2.3 乳房容積估測12 2.3.1 接觸性測量13 2.3.2 醫學影像16 2.3.3 體表掃描影像21 第三章 系統架構29 3.1 軟體流程29 3.2 軟體架構31 第四章 乳房容積估算方法34 4.1 研究對象34 4.2 研究工具34 4.3 研究方法35 4.3.1 建立基底數位模型36 4.3.2 座標系一致化37 4.3.3 特徵點設定44 4.3.4 乳房範圍47 4.3.5 骨骼特徵點匹配變形基底數位模型48 4.3.6 乳房容積計算方法66 4.3.7 軟體操作介面介紹80 第五章 乳房容積估算方法準確度驗證實驗83 5.1 BVE軟體分割乳房容積準確度驗證實驗83 5.2 以胸大肌變形技術估算乳房容積準確度驗證實驗86 5.3 可能影響乳房容積估算結果的因素97 5.3.1 胸大肌前側表面切點平均最短距離(dICP)與乳房容積估算誤差絕對值的關係98 5.3.2 胸骨上特徵點y軸間距與乳房容積估算誤差絕對值的關係105 第六章 討論與結論110 6.1 討論110 6.2 結論112 6.3 未來展望113 參考文獻114

    [1] L. C. Collins, R. M. Tamimi, H. J. Baer, J. L. Connolly, G. A. Colditz and S. J. Schnitt, "Outcome of patients with ductal carcinoma in situ untreated after diagnostic biopsy," Cancer, Vol.103, No.9, pp.1778-1784, 2005.
    [2] F. Ades, K. Tryfonidis and D. Zardavas, "The past and future of breast cancer treatment-from the papyrus to individualised treatment approaches," Ecancermedicalscience, Vol.11, p.746, 2017.
    [3] J. Haussmann, S. Corradini, C. Nestle-Kraemling, E. Bölke, F. J. D. Njanang, B. Tamaskovics, K. Orth, E. Ruckhaeberle, T. Fehm, S. Mohrmann, I. Simiantonakis, W. Budach and C. Matuschek, "Recent advances in radiotherapy of breast cancer," Radiation Oncology, Vol.15, No.1, p.71, 2020/03/30, 2020.
    [4] "Motiva Implants," <https://www.drjeremyhunt.com.au/blogs/using-motiva-implants-why-plastic-surgeon-dr-hunt-uses-motiva/>, 2023/07/19.
    [5] S. B. Choppin, J. S. Wheat, M. Gee, and A. Goyal, "The accuracy of breast volume measurement methods: A systematic review," The Breast, Vol.28, pp.121-129, 2016.
    [6] L. J. Sigurdson and S. A. Kirkland, "Breast Volume Determination in Breast Hypertrophy: An Accurate Method Using Two Anthropomorphic Measurements," Plastic and reconstructive surgery, Vol.118, No.2, pp.313-320, 2006.
    [7] 衛生福利部國民健康署, "十大癌症發生率(86-109)," <https://www.gender.ey.gov.tw/gecdb/Stat_Statistics_DetailData.aspx?sn=nLF9GdMD%2B%2Bv41SsobdVgKw%3D%3D>, 2023/02/01
    [8] A. J. Darlington, Anatomy of the Breast, in Digital Mammography: A Holistic Approach, Hogg, P., Kelly, J. and Mercer, C., Editors. 2015, Springer International Publishing: Cham. p. 3-10.
    [9] S. C. Willey, BREAST SURGERY, in Surgical Pitfalls, Evans, S. R. T., Editor. 2009, W.B. Saunders: Philadelphia. p. 433.
    [10] L. Tafra and Z. Cheng, Chapter 44 - Breast Biopsy and Breast-Conserving Surgical Techniques, in Surgical Pitfalls, Evans, S. R. T., Editor. 2009, W.B. Saunders: Philadelphia. p. 455-463.
    [11] S. C. Willey and E. D. Feldman, Chapter 46 - Mastectomy, in Surgical Pitfalls, Evans, S. R. T., Editor. 2009, W.B. Saunders: Philadelphia. p. 475-487.
    [12] W. S. Halsted, "I. The Results of Operations for the Cure of Cancer of the Breast Performed at the Johns Hopkins Hospital from June 1889, to January 1894," Ann Surg, Vol.20, No.5, pp.497-555, Nov, 1894.
    [13] J. S. Rankin, "William Stewart Halsted: A Lecture by Dr. Peter D. Olch," Annals of Surgery, Vol.243, No.3, pp.418-425, 2006.
    [14] G. H. SAKORAFAS and M. SAFIOLEAS, "Breast cancer surgery: an historical narrative. Part II. 18th and 19th centuries," European Journal of Cancer Care, Vol.19, No.1, pp.6-29, 2010.
    [15] J. L. MADDEN, S. KANDALAFT and R.-A. BOURQUE, "Modified Radical Mastectomy," Annals of Surgery, Vol.175, No.5, pp.624-634, 1972.
    [16] D. H. Patey and W. H. Dyson, "The prognosis of carcinoma of the breast in relation to the type of operation performed," Br J Cancer, Vol.2, No.1, pp.7-13, Mar, 1948.
    [17] M. Baum, "Modern concepts of the natural history of breast cancer: a guide to the design and publication of trials of the treatment of breast cancer," European journal of cancer, Vol.49, No.1, pp.60-64, 2013.
    [18] B. Fisher, "Laboratory and clinical research in breast cancer—a personal adventure: the David A. Karnofsky memorial lecture," Cancer research, Vol.40, No.11, pp.3863-3874, 1980.
    [19] M. Overgaard, P. S. Hansen, J. Overgaard, C. Rose, M. Andersson, F. Bach, M. Kjaer, C. C. Gadeberg, H. T. Mouridsen, M. B. Jensen and K. Zedeler, "Postoperative radiotherapy in high-risk premenopausal women with breast cancer who receive adjuvant chemotherapy. Danish Breast Cancer Cooperative Group 82b Trial," N Engl J Med, Vol.337, No.14, pp.949-55, Oct 2, 1997.
    [20] G. Corso, P. Veronesi, V. Sacchini, V. Galimberti and A. Luini, "The Veronesi quadrantectomy: an historical overview," Ecancermedicalscience, Vol.11, p.743, 2017.
    [21] U. Veronesi, A. Banfi, B. Salvadori, A. Luini, R. Saccozzi, R. Zucali, E. Marubini, M. Del Vecchio, P. Boracchi, S. Marchini, M. Merson, V. Sacchini, G. Riboldi and G. Santoro, "Breast conservation is the treatment of choice in small breast cancer: Long-term results of a randomized trial," European Journal of Cancer and Clinical Oncology, Vol.26, No.6, pp.668-670, 1990/01/01, 1990.
    [22] L. A. Newman and H. M. Kuerer, "Advances in breast conservation therapy," J Clin Oncol, Vol.23, No.8, pp.1685-97, Mar 10, 2005.
    [23] D. Cronin T, "Augmentation mammaplasty : A new "Natural feel" prosthesis," Transact, III Internat Congr Plast Surg, 1964, 1964.
    [24] C. Radovan, "Breast reconstruction after mastectomy using the temporary expander," Plastic and reconstructive surgery, Vol.69, No.2, pp.195-208, Feb, 1982.
    [25] V. Czerny, "Plastic replacement of the breast with a lipoma," Chir Kong Verhandl, Vol.2, No.2, p.216, 1895.
    [26] W. J. Schneider, H. L. Hill and R. G. Brown, "Latissimus dorsi myocutaneous flap for breast reconstruction," British Journal of Plastic Surgery, Vol.30, No.4, pp.277-281, 1977/10/01, 1977.
    [27] W. Mühlbauer and R. Olbrisch, "The latissimus dorsi myo-cutaneous flap for breast reconstruction," Chirurgia plastica, Vol.4, pp.27-34, 1977.
    [28] M. Nahabedian and A. B. Chagpar, "Options for autologous flap-based breast reconstruction," UpToDate. Waltham, MA, 2021.
    [29] C. R. Hartrampf, M. Scheflan and P. W. Black, "Breast reconstruction with a transverse abdominal island flap," Plastic and reconstructive surgery, Vol.69, No.2, pp.216-25, Feb, 1982.
    [30] R. J. Allen and P. Treece, "Deep inferior epigastric perforator flap for breast reconstruction," Annals of plastic surgery, Vol.32, No.1, pp.32-38, 1994.
    [31] N. M. Toyserkani, M. G. Jørgensen, S. Tabatabaeifar, T. Damsgaard and J. A. Sørensen, "Autologous versus implant-based breast reconstruction: A systematic review and meta-analysis of Breast-Q patient-reported outcomes," Journal of Plastic, Reconstructive & Aesthetic Surgery, Vol.73, No.2, pp.278-285, 2020.
    [32] F. G. Bouman, "Volumetric measurement of the human breast and breast tissue before and during mammaplasty," Br J Plast Surg, Vol.23, No.3, pp.263-4, Jul, 1970.
    [33] E. Tezel and A. Numanoglu, "Practical do-it-yourself device for accurate volume measurement of breast," Plastic and Reconstructive Surgery, Vol.105, No.3, pp.1019-1023, 2000.
    [34] B. N. Campaigne, V. L. Katch, P. Freedson, S. Sady and F. I. Katch, "Measurement of breast volume in females: description of a reliable method," Annals of Human Biology, Vol.6, No.4, pp.363-367, 1979/01/01, 1979.
    [35] A. Edsander-Nord, M. Wickman and G. Jurell, "Measurement of breast volume with thermoplastic casts," Scand J Plast Reconstr Surg Hand Surg, Vol.30, No.2, pp.129-32, Jun, 1996.
    [36] A. J. Grossman and L. A. Roudner, "A simple means for accurate breast volume determination," Plastic and reconstructive surgery, Vol.66, No.6, pp.851-852, 1980.
    [37] Q. Qiao, G. Zhou and Y. C. Ling, "Breast Volume Measurement in Young Chinese Women and Clinical Applications," Aesthetic Plastic Surgery, Vol.21, pp.362 -368, 1997.
    [38] R. Kayar, S. Civelek, M. Cobanoglu, O. Gungor, H. Catal and M. Emiroglu, "Five Methods of Breast Volume Measurement: A Comparative Study of Measurements of Specimen Volume in 30 Mastectomy Cases," Breast Cancer: Basic and Clinical Research, Vol.5, p.BCBCR.S6128, 2011.
    [39] C.-P. Chou, N.-J. Peng, T.-H. Chang, T.-L. Yang, C. Hu, H.-S. Lin, J.-S. Huang and H.-B. Pan, "Clinical roles of breast 3T MRI, FDG PET/CT, and breast ultrasound for asymptomatic women with an abnormal screening mammogram," Journal of the Chinese Medical Association, Vol.78, No.12, pp.719-725, 2015.
    [40] A. Salomon, "Beitrage zur Pathologic und Klinik der Mammacarcinoma," Arch. klin. Chir., Vol.103, pp.573-668, 1913.
    [41] R. A. Leborgne and L. C. de LEBORGNE, The Breast in Roentgen Diagnosis... English Translation by Lucy Crocker de Leborgne, Montevideo, 1953.
    [42] B. B. Priyanka and D. A. Kulkarni, "Digital mammography: a review on detection of breast cancer," International Journal of Advanced Research in Computer and Communication Engineering, Vol.5, No.1, pp.386-390, 2016.
    [43] C. L. Kalbhen, J. J. McGill, P. M. Fendley, K. W. Corrigan and J. Angelats, "Mammographic determination of breast volume: comparing different methods," American Journal of Roentgenology, Vol.173, No.6, pp.1643-1649, 1999/12/01, 1999.
    [44] J. J. Wild and D. Neal, "Use of high-frequency ultrasonic waves for detecting changes of texture in living tissues," The Lancet, Vol.257, No.6656, pp.655-657, 1951/03/24, 1951.
    [45] I. Allajbeu, S. E. Hickman, N. Payne, P. Moyle, K. Taylor, N. Sharma and F. J. Gilbert, "Automated Breast Ultrasound: Technical Aspects, Impact on Breast Screening, and Future Perspectives," Current Breast Cancer Reports, Vol.13, No.3, pp.141-150, 2021/09/01, 2021.
    [46] A. Vourtsis, "Three-dimensional automated breast ultrasound: Technical aspects and first results," Diagnostic and Interventional Imaging, Vol.100, No.10, pp.579-592, 2019/10/01, 2019.
    [47] 鄭國順, "電腦斷層 掃描系統," 科學發展 2004年10月,382期, 2004.
    [48] T. J. C. J. GORDON BETTS, U. O. N. C. A. C. H. PETER DESAIX, C. O. C. C. EDDIE JOHNSON, A. C. C. JODY E. JOHNSON, A. C. C. OKSANA KOROL, P. C. C. DEAN KRUSE, S. T. C. C. BRANDON POE, H. U. JAMES A. WISE, Y. S. U. MARK WOMBLE and C. S. U. KELLY A. YOUNG, LONG BEACH, Anatomy and Physiology, OpenStax, Apr 25, 2013.
    [49] E. Y. Rha, I. K. Choi and G. Yoo, "Accuracy of the Method for Estimating Breast Volume on Three-Dimensional Simulated Magnetic Resonance Imaging Scans in Breast Reconstruction," Plastic and reconstructive surgery, Vol.133, No.1, pp.14-20, 2014.
    [50] Z. Hussain, N. Roberts, G. H. Whitehouse, M. García-Fiñana and D. Percy, "Estimation of breast volume and its variation during the menstrual cycle using MRI and stereology," The British Journal of Radiology, Vol.72, No.855, pp.236-245, 1999.
    [51] W. K. Moon, Y.-W. Shen, C.-S. Huang, S.-C. Luo, A. Kuzucan, J.-H. Chen and R.-F. Chang, "Comparative study of density analysis using automated whole breast ultrasound and MRI," Medical Physics, Vol.38, No.1, pp.382-389, 2011.
    [52] M. Herly, F. C. Müller, M. Ørholt, J. Hansen, S. Sværke, M. N. Hemmingsen, B. S. Rasmussen, J. J. Elberg, K. T. Drzewiecki and P. V. Vester-Glowinski, "The current gold standard breast volumetry technique seems to overestimate fat graft volume retention in the breast: A validation study," Journal of Plastic, Reconstructive & Aesthetic Surgery, Vol.72, No.8, pp.1278-1284, 2019/08/01, 2019.
    [53] M. Erić, A. Anderla, D. Stefanović and M. Drapšin, "Breast volume estimation from systematic series of CT scans using the Cavalieri principle and 3D reconstruction," International Journal of Surgery, Vol.12, No.9, pp.912-917, 2014.
    [54] M. J. Kim, T. W. Kim, H. M. Hahn and I. J. Lee, "Clinical use of perioperative magnetic resonance imaging-based breast volumetric analysis in final implant volume prediction for two-stage breast reconstruction," Annals of Surgical Treatment and Research, Vol.103, No.4, p.195, 2022.
    [55] A. Losken, H. Seify, D. D. Denson, A. A. J. Paredes and G. W. Carlson, "Validating Three-Dimensional Imaging of the Breast," Annals of plastic surgery, Vol.54, No.5, pp.471-476, 2005.
    [56] M. Eder, F. v. Waldenfels, A. Swobodnik, M. Klöppel, A.-K. Pape, T. Schuster, S. Raith, E. Kitzler, N. A. Papadopulos, H.-G. Machens and L. Kovacs, "Objective breast symmetry evaluation using 3-D surface imaging," The Breast, Vol.21, No.2, pp.152-158, 2012/04/01, 2012.
    [57] S. T. L. Pöhlmann, E. Harkness, C. J. Taylor, A. Gandhi and S. M. Astley, "Preoperative implant selection for unilateral breast reconstruction using 3D imaging with the Microsoft Kinect sensor," J Plast Reconstr Aesthet Surg, Vol.70, No.8, pp.1059-1067, Aug, 2017.
    [58] T. Wesselius, R. Vreeken, A. Verhulst, T. Xi, T. Maal and D. Ulrich, "New software and breast boundary landmarks to calculate breast volumes from 3D surface images," European journal of plastic surgery, Vol.41, No.6, pp.663-670, 2018.
    [59] M. W. Göpper, J. Neubauer, Z. Kalash, G. B. Stark and F. Simunovic, "Improved accuracy of breast volume calculation from 3D surface imaging data using statistical shape models," PloS one, Vol.15, No.11, p.e0233586, 2020.
    [60] M. P. Chae, W. M. Rozen, R. T. Spychal and D. J. Hunter-Smith, "Breast volumetric analysis for aesthetic planning in breast reconstruction: a literature review of techniques," Gland surgery, Vol.5, No.2, pp.212-226, 2016.
    [61] J. S. Kim, K. Bae, E. J. Lee and M. Bang, "Mammography with a fully automated breast volumetric software as a novel method for estimating the preoperative breast volume prior to mastectomy," Ann Surg Treat Res, Vol.100, No.6, pp.313-319, 2021.
    [62] "LightSpeed VCT," <https://www.bctechnical.com/systems/vct-64/>.
    [63] "SOMATOM_Definition_Edge," <https://www.siemens-healthineers.com/computed-tomography/single-source-ct-scanner/somatom-definition-edge>.
    [64] J. de Vries, Learn OpenGL: Learn Modern OpenGL Graphics Programming in a Step-by-step Fashion, pp. 82-106 Kendall & Welling, 2020.
    [65] ChiaWei, "舒緩肩膀肌肉," 2021/03/26, <https://www.facebook.com/ChiaWeiRehab/photos/a.151734086243686/466099098140515/?type=3>.
    [66] goukakuouenman, "胸骨解剖學," 2021/03/13, <https://twitter.com/goukakuouenman/status/1370766454094589952>.
    [67] K. Nie, J.-H. Chen, S. Chan, M.-K. I. Chau, H. J. Yu, S. Bahri, T. Tseng, O. Nalcioglu and M.-Y. Su, "Development of a quantitative method for analysis of breast density based on three-dimensional breast MRI," Medical Physics, Vol.35, No.12, pp.5253-5262, 2008.
    [68] M. Lin, J.-H. Chen, X. Wang, S. Chan, S. Chen and M.-Y. Su, "Template-based automatic breast segmentation on MRI by excluding the chest region," Medical Physics, Vol.40, No.12, p.122301, 2013.
    [69] Z. Cha and C. Tsuhan, "Efficient feature extraction for 2D/3D objects in mesh representation," in Proceedings 2001 International Conference on Image Processing (Cat. No.01CH37205), pp.935-938, 2001.
    [70] A. G. Asuero, A. Sayago and A. G. González, "The Correlation Coefficient: An Overview," Critical Reviews in Analytical Chemistry, Vol.36, No.1, pp.41-59, 2006/01/01, 2006.

    下載圖示 校內:立即公開
    校外:立即公開
    QR CODE