本研究內容主要是針對鈣磷系骨水泥機械性質、微結構、動物實驗及臨床反應做一系列的探討，本實驗室已發展出非常適合作為生醫植入材的骨水泥，從結果發現nd-CPC在相同的條件下尤其是在反應初期階段比起c-CPC顯示有較為緻密的型態，具較高的磷灰石生成速率，nd-CPC在硬化及浸泡於模擬人工體液過程表現較高的強度。
　　反應過程中較後的階段大量Ca/P比接近HA的磷灰石晶體/鬚晶生成並有效的連接DCPA顆粒，藉著這些磷灰石晶體/鬚晶橋接大顆的TTCP顆粒並將其位置固定住，此時CPC達到硬化，顯微結構研究結果發現CPC通常在經過20到40分鐘反應後浸泡於模擬人工體液就不會溶解是因為大量鬚晶的生成將粉末互相連結。
　　為了使nd-CPC更為實用，本實驗室以熱處理方式提供了一個熱處理方式（例如160-180℃處理1小時），此方式可以大幅度的改善以TTCP/DCPA為主要材料的鈣磷系骨水泥工作及硬化時間。n-CPC在動物植入方面具有相當高的吸收速率，植入兔子大腿骨24週的吸收率約50％，並且在牙科的臨床方面初步結果顯示並無不良反應有很好的組織相容性。
　　總體而言，鈣磷系骨水泥nd-CPC是新一代生醫材料相當好的選擇。

　　The present work is a study of the mechanical properties, microstructure, animal and clinical study of a series of non-decay calcium phosphate cements. The author’s lab has developed a new calcium phosphate cement and showed excellent properties as a bone substitutes. From the results revealed that the apatite formation rate of nd-CPC was higher than that of c-CPC, especially at early stage. The nd-CPC showed a denser morphology, higher strength than c-CPC both during setting and after immersion in Hanks’ solution.
　　During the later stages of reaction, the extensive growth of apatite crystals/whiskers, with a Ca/P ratio very close to that of HA, effectively linked particles together. It is suggested that, when the particles are locked in place by the bridging apatite crystals/whiskers, the CPC is set and would not dissolve when immersed in Hanks' solution after 20-40 min of reaction.
　　For practical used, we provide a simple heat treatment method that can largely modify the working/setting time of TTCP/DCPA-derived CPC without using additives or sacrificing its strength. It can be seen that the nd-CPC cement can induce the growth of the natural bone, the resorb ratio was about 50% after 24 weeks implanted. From the result of nd-CPC clinical study applied in dental, no side reaction revealed nd-CPC has good biocompatibility. The nd-CPC has great potential for use as implant material.

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