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研究生: 楊峻嘉
Yang, Chun-Chia
論文名稱: 基於預測編碼模型之耳鳴聲音療法
A Predictive Coding Model-Based Sound Therapy on Treating Tinnitus
指導教授: 林宙晴
Lin, Chou-Ching
學位類別: 碩士
Master
系所名稱: 工學院 - 生物醫學工程學系
Department of BioMedical Engineering
論文出版年: 2023
畢業學年度: 111
語文別: 英文
論文頁數: 64
中文關鍵詞: 耳鳴治療聲音療法預測編碼謝帕德音調聽覺錯覺音高
外文關鍵詞: Tinnitus treatment, sound therapy, predictive coding, shepard tone, auditory illusion, pitch
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  • 本研究提出了一種基於預測編碼模型的新型聲音療法,以此緩解耳鳴症狀。為了評估該治療的有效性,我們以隨機、單盲、安慰劑對照的方式招募了40名慢性耳鳴患者進行試驗。本研究於聲音治療前、後使用純音聽力測驗(PTA)、耳鳴聲學測量與耳鳴障礙量表等臨床測量方法進行治療效果的評估。結果表明與安慰劑組相比,新型聲音療法明顯降低了耳鳴障礙程度,並在耳鳴音高方面造成了更大的變化;治療組受試者在完成治療後二週的測驗中也報告耳鳴困擾程度顯著降低。綜上所述,我們的新型聲音療法能夠有效地抑制耳鳴。

    In this study, a novel predictive coding model-based sound therapy was proposed to relieve tinnitus symptoms. To evaluate the effectiveness of this therapy, we enrolled 40 patients with chronic tinnitus in a randomized, single-blind, placebo-controlled trial. Treatment outcomes were assessed using clinical measurements such as pure tone audiometry (PTA), tinnitus matching test, and tinnitus handicap inventory (THI) before and 2 weeks after sound therapy. The results showed that our novel sound therapy significantly reduced tinnitus severity and resulted in a stronger change in tinnitus pitch when compared to placebo. Participants in the treatment group also reported a significant decrease in tinnitus annoyance at 2 weeks after treatment completion. It was concluded that our novel sound therapy was effective in reducing tinnitus.

    中文摘要 i Abstract ii 誌謝 iii Contents iv List of Tables vii List of Figures viii 1 Introduction 1 1.1 General Introduction of Tinnitus 1 1.2 Hypotheses Regarding Mechanisms of Tinnitus 2 1.2.1 Tonotopic map reorganization 2 1.2.2 Central auditory gain 3 1.2.3 Thalamocortical dysrhythmia 4 1.2.4 Predictive coding 5 1.3 Treatments for Tinnitus 7 1.3.1 Pharmacological / drug 7 1.3.2 Cognitive behavioral therapy 7 1.3.3 Neurophysiological treatments 8 1.4 Acoustic Therapies 9 1.4.1 Hearing aids 10 1.4.2 Tinnitus retraining therapy 11 1.4.3 Notched music training 11 1.4.4 Acoustic coordinated reset neuromodulation 12 1.5 Shepard Tone 12 1.6 Motivation and Goal 15 2 Materials and Methods 17 2.1 Subjects 17 2.1.1 Study subjects 17 2.1.2 Inclusion criteria 17 2.1.3 Exclusion criteria 18 2.2 Experimental Design 18 2.3 Sound Stimulation Protocol 19 2.4 Generation of the Sound Therapy 21 2.5 Evaluation of the Sound Stimulation 23 2.6 Evaluation Procedure 25 2.7 Data Analysis 27 3 Results 29 3.1 Demographics and Tinnitus Characteristics of Participants 29 3.2 Within-Group and Between-Group Therapeutic Effects on Tinnitus 31 3.2.1 Differences of tinnitus characteristics and THI scores 31 3.2.2 Therapeutic effects of the intervention 34 3.3 Impact of Tinnitus Severity on the Success of Sound Therapy 36 4 Discussion 42 4.1 Outcome of the Sound Therapy 42 4.1.1 Changes of tinnitus characteristics 43 4.1.2 Induced changes on tinnitus severity 45 4.2 Clinical Implications 49 4.3 Limitations of the Study 49 5 Conclusions 51 5.1 Conclusions 51 5.2 Recommendations for Future Research 52 References 54 Appendix A: Tinnitus Handicap Inventory (THI) 64

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