人工心臟為心臟衰竭患者等待移植期間的重要橋樑，其可替代患者之心臟功能，延續患者生命，目前人工心臟之內球囊多使用聚氨酯(polyurethane, PU)作為血液接觸材料，然而，氣動式人工心臟其內球囊與外球囊間存在一氣室，利用該氣室的氣體壓力變化使內球囊收縮與舒張以推動血液循環，長期使用之下，血液中的水氣會因滲透壓差而擴散至氣室中，促使氣室間之濕度上升，一但濕度達到飽和則水氣將凝結成水珠，水珠的形成將造成人工心臟連接外接設備之線路短路進而導致儀器損壞或是產生積垢問題而滋生細菌，減少儀器壽命。
　　聚（苯乙烯－異丁烯－苯乙烯）(poly (styrene-block-isobutylene-block-styrene), SIBS) 三嵌段聚合物為生物穩定之材料，具有不可滲透之特性。本實驗利用浸塗製程(dip-coating process)製備PU-SIBS-PU複合球囊，於聚氨酯層之間穿插聚（苯乙烯－異丁烯－苯乙烯）層，形成三明治結構以降低球囊之水器穿透速率。透過改變浸塗製程之參數（拉提速率、溶液濃度）以獲得無缺陷之SIBS層，透過電子顯微鏡(OM)、掃描式電子顯微鏡(SEM)，觀察表面及截面型態；水氣穿透實驗與拉伸試驗量測材料之阻水性及機械性質；血液相容性實驗及細胞毒性實驗以評估此材料是否可作為血液接觸之材料。
綜合各實驗結果，利用浸塗製程的參數變化成功製備出PU-SIBS-PU複合球囊，透過添加SIBS層於PU層之間，其結果顯示能夠有效減少37.6%的水氣穿透，並且具有良好的血液相容性及生物相容性。

Artificial heart is a bridge for patients with heart failure waiting for transplantation. However, under long-term use, the water in the blood will diffuse into the air chambers due to the osmotic pressure difference, which will increase the humidity between the air chambers. Once the humidity reaches saturation, it will condense into droplets. The formation of water droplets will cause a short circuit between the artificial heart and external equipment, which will cause damage to the instrument or cause fouling problems, which will breed bacteria and reduce the life of the instrument. The formation of water droplets will cause damage to the external equipment connected to the artificial heart or cause fouling and bacteria, which will reduce the life of the instrument.
Poly (styrene-block-isobutylene-block-styrene) (SIBS) is a biostable material with impermeable properties. In this study, PU-SIBS-PU composite sac was prepared by dip-coating process. SIBS layer was inserted between the polyurethane layers to form a sandwich structure to reduce the penetration rate of the sac.
According to the results, we successfully fabricated PU-SIBS-PU sac through the dip coating process. By inserting the SIBS layer between the PU layers, the results show that it could effectively reduce the penetration of water vapor and had good blood compatibility and biocompatibility.

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