摻雜鑭系元素的上轉換奈米粒子將近紅外光轉換成紫外光與可見光波段區域的性質近年來被蓬勃的應用在生醫癌症治療上。本實驗先合成棒狀的上轉換奈米粒子，然後將二氧化矽包覆外圍使材料轉水相，接著在二氧化矽的表面修飾上3-氨基丙基三甲氧基甲矽烷(APTES)使其表面帶正電，再用晶種成長法在二氧化矽的表面包覆上金殼，最後再利用鹼性氨水溶液將二氧化矽水解侵蝕，進而形成創新的rod-in-shell結構。由於金殼藉由表面電漿耦合可以增強上轉換奈米粒子的螢光放光，在生物顯影的應用會更有利也會幫助腫瘤位置的標定；另外金殼本身也能用來做光熱治療，因此本材料在生醫上可以做有效的應用與癌症的治療。

Lanthanide-doped upconversion nanoparticles converting near-infrared light to visible light have been recognized as an efficient and versatile tool of bioimaging and cancer therapy. Herein, we synthesize upconversion nanorods coated with silica shell modifying (3-Aminopropyl)triethoxysilane outside the surface. And these UCNP@SiO2-APTES are encapsulated in gold nanoshell by well-known seed growth method. After accomplishing double layer core shell UCNP@SiO2-Au shell, the final step is to etch the silica layer in basic ammonia solution by hydrolysis and construct a rod-in-shell structure. The gold nanoshell will be expected to increase upconversion fluorescence due to surface plasmon-coupled emission; therefore application in bioimaging will be more obviously and benefit for tumor targeting. Besides gold nanoshell exist photothermal therapy for ablation of tumor cell as well. As the result, the composite rod-in-shell nanostructure may have great potential for applications in biomedical imaging and cancer treatment.

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