開放性復位及內固定手術是臨床上最常用的骨折治療方式，目前臨床常見的骨釘骨板材料為不鏽鋼、鈦合金等，這些惰性材料可能使骨折患者出現強烈異物感，且長期存在於植入部位也會影響骨頭的修復成效。在近幾年的研究中，鎂合金作為新一代生醫材料，具備可降解的特性，其力學性質與人體骨骼相近，降解後的鎂離子也能參與體內各項生理活動，這些特性可以減輕患者的疼痛，更能提供骨頭良好的再生環境。然而由於鎂合金的活性較高，接觸到體液後便會開始快速降解，可能導致植入後的力學強度損失過快。
為有效提升鎂合金的應用範圍，透過表面處理可提升鎂合金的力學性質和降解機制。藉由微弧氧化表面改質技術，可提高鎂合金的表面硬度、耐磨特性與耐腐蝕表現。此外亦可在製作塗層時改良電解液中的成分，以優化微弧氧化過程中所產生的表面孔隙，達到更良好的抗腐蝕特性。
本研究選用ZK60鎂鋅鋯合金作為植入物基材，以提供良好的力學性能和優異的生物相容性。在表面處理製程中，使用微弧氧化技術來為細胞創造適當的生長微環境。此外亦將於電解液中添加氧化鈰奈米顆粒，以改善整體的降解機制並促進骨頭再生。在本研究結果中顯示，添加氧化鈰奈米顆粒於微弧氧化塗層，可改善塗層的耐磨性、優化鎂合金的降解模式，亦可增強骨細胞的生長表現。此外，在紐西蘭大白兔的體內實驗中，氧化鈰奈米顆粒可以促進新生骨組織與原生骨組織之間的連接，提供良好的生物相容性與卓越的骨重塑能力，顯著提升可降解鎂合金骨科植體的發展潛力。

Open reduction and internal fixation surgery represent the predominant approach for managing fractures in clinical practice. Presently, stainless steel and titanium alloys are the materials most frequently employed for bone screws and plates. These inert materials can elicit an apparent foreign body sensation in patients with fractures, and their prolonged presence at the implantation site may adversely influence the efficacy of bone healing.
Magnesium alloys have emerged as a novel class of biodegradable materials in recent years. Their mechanical properties closely resemble human bone, and the magnesium ions released during degradation can engage in various physiological processes within the body. These attributes mitigate patient discomfort and provide a conducive environment for bone regeneration. However, the high reactivity of magnesium alloys results in rapid degradation upon exposure to bodily fluids, potentially leading to a premature loss of mechanical strength post-implantation.
Surface treatments can enhance magnesium alloys' mechanical properties and degradation profiles to broaden their applicability. Implementing micro-arc oxidation surface modification technology can significantly improve magnesium alloys' surface hardness, wear resistance, and corrosion resistance. Furthermore, the electrolyte composition can be adjusted to optimize the surface porosity generated through micro-arc oxidation, thereby achieving superior corrosion resistance.
This study utilized ZK60 magnesium-zinc-zirconium alloy as the implant substrate, owing to its favorable mechanical properties and excellent biocompatibility. The surface treatment involved the application of micro-arc oxidation technology to establish an optimal microenvironment for cellular growth. Additionally, cerium oxide nanoparticles were incorporated into the electrolyte to enhance the overall degradation mechanism and promote bone regeneration. The findings of this study indicated that the inclusion of cerium oxide nanoparticles in the micro-arc oxidation coating improved the wear resistance of the coating, optimized the degradation behavior of the magnesium alloy, and enhanced the proliferation of bone cells.
Moreover, in vivo experiments conducted on New Zealand white rabbits demonstrated that cerium oxide nanoparticles facilitated the integration of nascent bone tissue with native bone tissue, exhibiting commendable biocompatibility and exceptional bone remodeling capabilities. These results significantly augment the developmental potential of biodegradable magnesium alloy orthopedic implants.

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