癌症是全球主要的死亡原因，採用多模式療法的奈米醫學的發展已顯示出在提高治療效果同時減少副作用方面的前景。與光動力療法相比，聲動力療法可提供更深的穿透深度。在此，我們設計了一種奈米藥物FePt@MIL−125−NH2−Pt(IV)，用於協同化療、化學動力學和聲動力學治療。鐵鉑奈米粒子的鐵成分可以執行芬頓反應進行化學動力學治療，在腫瘤微環境中產生活性氧。鐵鉑奈米粒子的鉑成分可作為分解過氧化氫產生水和氧氣的催化劑。因為腫瘤微環境中高濃度的過氧化氫和缺氧環境會降低聲音動力療法的有效性。MIL−125−NH2是一種含有鈦的半導體金屬有機骨架，在超音波照射下可以產生分離的電子和電洞。然後電子可以將氧還原成單重態氧，而電洞可以將水氧化成羥基自由基。最後，金屬有機骨架的胺基可以透過醯胺鍵與化療藥物順鉑前驅藥物藥結合。這種整合旨在克服滲透深度的限制並改進多模式抗癌治療。FePt@MIL−125−NH2−Pt(IV)的粒徑為170 ± 5nm。FePt@MIL−125−NH2−Pt(IV)是半導體，根據紫外可見光光譜計算出能帶間隙為2.3 eV。鐵鉑奈米粒子的負載量為4.54 ± 0.72 wt%，順鉑前驅藥物的負載量為 4.70 ± 1.23 wt%。穀胱甘肽是還原劑，可以還原Fe3+和順鉑前驅藥物，幫助鐵和鉑釋放。 鉑可以催化過氧化氫產生氧氣。在共軛焦雷射掃描顯微鏡影像中FePt@MIL−125−NH2−Pt(IV)產生的綠色螢光最多，顯示出高效的活性氧生成。

Cancer is a leading global cause of death, and the development of nanomedicine with multimodal therapies has shown promise in enhancing therapeutic efficacy while reducing side effects. Sonodynamic therapy, compared to photodynamic therapy, offers deeper penetration depth. Herein, we design a nanomedicine FePt@MIL−125−NH2−Pt(IV) for synergistic chemotherapy, chemodynamic therapy (CDT), and sonodynamic therapy (SDT). The Fe component of FePt performs the Fenton reaction for CDT, generating reactive oxygen species in the tumor microenvironment (TME). The Pt component of FePt acts as a catalyst for decomposing H2O2 to produce H2O and O2. This is crucial because a high concentration of H2O2 and a hypoxic environment in the TME can reduce the effectiveness of SDT. MIL−125−NH2, a semiconducting metal−organic frameworks (MOFs), can generate separated electrons and electron holes under ultrasonic wave irradiation. The electrons can then reduce O2 into ‧O2−, while electron holes can oxidize H2O into ‧OH. Finally, the free amino groups of the MOFs can conjugate with Pt(IV)−prodrug via amide bond formation, contributing to chemotherapy. This integration aims to overcome limitations in penetration depth and improve the multimodal anticancer treatments.

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