CPC（calcium phosphate cement）磷酸鈣骨水泥是以等量的鹼性TTCP（Ca4（PO4）2O）與酸性DCPA（CaHPO4）或DCPD（CaHPO4.2H2O）混合，以水作為硬化溶液，在室溫下可合成氫氧基磷灰石(Hydroxyapatite；簡稱HA)；而氫氧基磷灰石具有良好的生物相容性與生物活性，植入人體後不會引起毒性，不刺激組織，具有引導骨骼向內生長，及在骨骼外組織誘導骨細胞分化生長的能力。

　　本實驗室已發展出非常適合作為生醫植入材的骨水泥，但仍須改善其植入後機械性質退化的速率，希望其得以與骨細胞生長的速率達成穩定的平衡，以有效修補並重建缺損的骨組織。

　　本研究內容主要是針對鈣磷系骨水泥以動物實驗後之機械性質、微結構及生物性質做一系列的探討，比較一般以體外模擬人工體液(Hanks’Solution)與實際植入於動物體內時，材料機械性質與微結構隨著時間的變化而產生的差異性。發現機械性質有很大的不同，且體內環境並不比體外環境來的嚴苛，或許可藉此提供此類鈣磷系骨水泥改良的基礎。

　　CPC (calcium phosphate cement) is synthesized by mixing equal amout of alkaline TTCP (Ca4(PO4)2O) and acid DCPA (CaHPO4) or DCPD (CaHPO4.2H2O); setting with pure water to synthesize HA (Hydroxyapatite). HA has superior biocompatibility, bioactivity, and osteoconduction, without any toxicity or irritation after implantation.

　　CMRT laboratory have researched a kind of bone cement which is suitable for biomedical implantation. But the cement still need to improve the decay rate of mechanical properties after implantation. It is expect to achieve a stable equilibrium with bone growing rate to reinforce the damaged bone tissues.

　　This investigate is to probe into the mechanical properties, microstructure, and biological properties after animal implantation. Compare with the cement immersing in Hanks’ Solution. The result showed a great differentiation of mechanical strength between the in vivo test and in vitro test. The information also provide the direction of this material’s improvement.

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經濟部陶瓷技術手冊 Chap.31