在臨床上，竇狀隙阻塞症候群為一種藥物引起的肝臟傷害。過去研究顯示食入含砒咯啶生物鹼的植物，如野百合鹼，亦會引起竇狀隙阻塞症候群。這類植物鹼會使竇狀隙內皮細胞型態改變，而釋出基質金屬蛋白酵素降解細胞外基質，引起血球阻塞及嗜中性白血球浸潤，進而使肝臟產生氧化壓力。芝麻油具有良好抗氧化能力，而芝麻酚為芝麻油中最具有抗氧化能力的成分。本研究主要探討事前、事後給予芝麻油及事後給予芝麻酚，是否能減緩野百合鹼誘發竇狀隙阻塞症候群所造成的大鼠肝臟傷害情形。由實驗結果顯示，事先給予芝麻油 (1 mL/kg) 能夠有效降低血清中的丙胺酸轉胺酶和天門冬胺酸轉胺酶、抑制肝臟中基質金屬蛋白酵素-9活性、提高基質金屬蛋白酵素組織抑制因子-1的表現及維持膠原蛋白和層黏蛋白的含量；另外，事先給予芝麻油也能夠有效降低骨髓過氧化酶活性、抑制脂質過氧化及維持肝臟穀胱甘肽含量。而事後給予芝麻油並無法有效的減緩肝臟傷害。然而，在事後給予芝麻酚 (20 mg/kg) 實驗中，發現芝麻酚亦能有效降低血清中的丙胺酸轉胺酶和天門冬胺酸轉胺酶、抑制肝臟中基質金屬蛋白酵素-9活性、提高基質金屬蛋白酵素組織抑制因子-1的表現、維持膠原蛋白和層黏蛋白的含量、降低骨髓過氧化酶活性、抑制脂質過氧化及維持肝臟穀胱甘肽含量，達到有效的減緩肝臟傷害。因此，由以上實驗結果顯示，事前給予芝麻油具有保護效果，可能是藉由降低基質金屬蛋白酵素-9的活性和氧化壓力，達到減緩竇狀隙阻塞症候群造成的大鼠肝臟傷害。此外事後給予芝麻酚，也能夠藉由降低基質金屬蛋白酵素-9的活性和氧化壓力，達到有效的治療效果。

Sinusoidal obstruction syndrome (SOS) is drug-induced liver injury and dietary ingestion of pyrrolizidine alkaloid (monocrotaline) also causes SOS. Monocrotaline causes rounding-up of sinusoidal endothelial cells (SECs) that release matrix metalloproteinase-9 (MMP-9). Release of MMP-9 resulted in breakdown of extracellular matrix that induces sinusoids obstruction, neutrophil recruitment, and oxidative stress in liver. Sesame oil is a potent antioxidant and seamol is the most potent antioxidant in sesame oil. The aims of study were to assess the prophylactic and therapeutic effect of sesame oil and therapeutic effect of sesamol on monocrotaline-induced SOS in male Sprague-Dawley rats. Results showed that sesame oil 1 (mL/kg) prophylactically (1) decreased Aspartate aminotransferase (AST) and Alanine transaminase (ALT), (2) inhibited MMP-9 and increased tissue inhibitor of metalloproteinase-1 (TIMP-1), (3) maintained collagen and laminin, (4) decreased myeloperoxidase (MPO) and lipid peroxidation (LPO), and (5) maintained glutathione on monocrotalined-induced SOS rats. But therapeutic sesame oil showed no effect against monocrotaline-induced SOS rats. Furthermore, sesamol had better therapeutic effect than therapeutic effect of sesame oil. Sesamol (20 mg/kg) (1) decreased AST and ALT, (2) inhibited MMP-9 and increased TIMP-1, (3) maintained collagen and laminin, (4) decreased MPO and LPO, and (5) maintained GSH on monocrotalined-induced SOS rats. Thus, sesame oil prophylatically and sesamol therapeutically attenuated monocrotaline-induced SOS in rats by inhibiting MMP-9 and oxidative stress; however, sesame oil was therapeutically inefficient which might be declined metabolism and obstructed circulation in liver.

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