社會壓力會擾亂生理平衡而誘導心肺傷害，近年來許多人常藉由燃燒芳香蠟燭所散發之香氣來進行舒壓，燃燒芳香蠟燭會排放出許多有害空氣汙染物，可能引發健康危害。本研究欲探討處於社會壓力下，暴露含 3% 薰衣草精油芳香蠟燭燃燒產物對小鼠心肺功能之影響。實驗將經社會壓力動物模式處理之小鼠置於暴露腔中，給予暴露每天 4.5 小時，每週連續五天的芳香蠟燭燃燒產物，共持續四或八週。研究結果顯示，小鼠經暴露四或八週芳香蠟燭燃燒產物，無法降低社會壓力誘導之皮質酮含量。暴露四週芳香蠟燭燃燒產物更顯著增強社會壓力誘導之肺臟傷害（肺水腫、肺臟中介白質 1β 表現與 NF-κB 活性）。而隨著暴露芳香蠟燭燃燒產物時間增加，除了暴露四週所引發的傷害外，更加劇社會壓力誘導之心臟傷害，包括：心臟傷害指標（乳酸脱氫酶、磷酸肌酸激酶、心肌型肌酸激酶）活性增加、心臟中促發炎細胞激素（腫瘤壞死因子 α、介白質 6、介白質 1β）表現增加與加劇心肌缺氧（低氧誘導因子-1α 與 B 型排鈉利尿胜肽含量增加）。綜合上述，小鼠暴露 3% 薰衣草精油芳香蠟燭燃燒產物會隨著暴露時間的增加，而加劇社會壓力誘導之心肺傷害。

Social stress may induce cardiopulmonary injury by disrupting the body’s homeostasis. Recently, scented candles were used to relieve stress. However, numerous air pollutants produced from burning scented candles may cause poor health outcomes. The aim of the study was to investigate effects of scented candle combustion products exposure on social stress-induced cardiopulmonary injury in mice. Mice with social disruption stress (SDR) were exposed to combustion products of 3% lavender scented candles (4.5 h/d, 5 d/wk) in an exposure chamber for different time course (4 or 8 wk). Results showed exposure to combustion products of scented candle failed to reduce serum corticosterone level in SDR-treated mice in 4 and 8 weeks study. Exposure to combustion products of scented candle time-dependently enhanced SDR-induced pulmonary edema, tumor necrosis factor (TNF)-α, interleukin (IL)-6, interleukin (IL)-1β levels, and nuclear factor (NF)-κB activity in lung. Further, combustion products of scented candle time-dependently increased lactic dehydrogenase, creatine phosphokinase, and heart type creatine kinase isoenzyme levels in serum, hypoxia-inducible factor (HIF)-1α, and B-type natriuretic peptide levels in SDR-treated mice. It is concluded that exposure to combustion products of 3% lavender scented candle may time-dependently exacerbated social stress-induced cardiopulmonary injury.

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