先前由CMRT(Cana Materials Research Team)經多年努力所開發出之鈣基骨泥(Calcium-based cement, CBC)具有優越的物化性質、生物相容性及骨引導性，對骨取代物而言，為了進一步降低骨科、牙科手術術後感染的風險，期望以添加非抗生素的方式對材料具備抗菌性，因此以CMRT(Cana Materials Research Team)開發的鈣基骨泥(Calcium-based cement, CBC)為基礎，製備抗菌CBC促使環境pH值提升以達到抗菌的效果，但因添加抗菌粉末將使基材CBC的反應互相牽制導致機械強度下降，故此研究決定以改善製程來提升材料的機械性質。
雖然抗菌粉末的添加能有效使材料具備抗菌性，卻也使材料的機械強度降低，為了減少抗菌粉末與基底材料反應所造成的影響性，以加壓的方式來改善此問題，探討不同製程對材料性質之影響。
研究成果可以發現，將抗菌粉末與不同液體混合、加壓成形後加入CBC基材中將能提升機械強度，並且搭配適當的液粉比，具有良好的注射性與不崩解性，在生物實驗方面，則擁有良好抗菌性，在浸泡Medium二天後之試片細胞存活率達70%以上。

The calcium phosphate/calcium sulfate composite developed by CMRT(Cana Materials Research Team) has excellent physical properties, chemical properties and biocompatibility. Generally, antibiotics are added to bone substitute to decrease the possibility of postoperative infection.
In our study, we chose antibacterial powder as the antibacterial additive. Though the addition of antibacterial powder dramatically enhanced the antibacterial capacity, it took away the mechanical strength. To solve this problem, we tried to use pressing powder by decreasing the interaction between antibacterial powder and matrix material. The results show that the addition of the powder is capable of improving compressive strength. By the way, it also attains enough mechanical strength without dispersion. In the aspect of biology, it has not only enough antibacterial capacity but also good biocompatibility which is proved by cytotoxicity experiments.

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