近年石墨烯相關研究快速發展為各種領域注入新活力，其中石墨烯為穩定碳材料具備生物相容性，因此也在生醫方面成為熱門的明日之星。
其中石墨烯用於表面增強拉曼散射技術被快速發展，然而相關製程昂貴大幅限制其商品應用，因此本文提出了一種新的石墨烯複合金屬電漿子結構基板製作技術，以熱化學氣相沉積法在銅箔上成長高密度石墨烯島群結構，隨後以金屬反應液進行無極電鍍，由於自由能差異會在島群間隙內優先選擇性沉積金屬奈米顆粒，藉由控制並優化石墨烯奈米或量子結構的尺寸、密度和分布，可以自組裝地形成一維、二維奈米金屬顆粒陣列和網目，以石墨烯調控奈米金屬顆粒間距離至適當的位置，在雷射光激發下顆粒間電場相互耦合並增強物理機制，而石墨烯可以藉由螢光淬滅與ππ*吸引待測分子提供增強化學機制，兩機制互輔互成為此基板高表現建立基礎。

We reported the fabrication of graphene quantum dots (GQDs) on Cu substrates by thermal Chemical Vapor Deposition (CVD). The synthesized high-density graphene quantum dots exhibit strong surface enhanced Raman scattering (SERS) effects. Besides, we also demonstrate an advanced plasmonic sensor by combining GQDs with self-assembled silver (Ag) and gold (Au) nanoparticles (NPs) to enhance SERS signal intensity, which is up to 10^14 times stronger than the normal signal gained from a surface without nanoparticles and GQDs. The preferred nanoscale distance of 3~10nm between neighboring graphene quantum dots-silver nanoparticles hybrid were formed. As this time, the nanostructures were favorable for plasmonic coupling enhanced high local electric fields, which lead to greatly enhanced strength of signal from Raman scattering of probe molecules on the substrate as an effective means of detecting, identifying, and measuring low concentration molecules of scientific and technological significance. These results may pave the way toward a large-scale and low-cost SERS sensors with high performance.

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