中文摘要
P-glycoprotein (Pgp)是一個與抗癌藥物之多重抗藥性(multiple-drug resistance)有關的運送子。Pgp其主要作用能將藥物自細胞內排出，因而降低藥物於細胞內的蓄積。
文獻指出厭水性的peptide，如ALLN (N-acetyl-leucyl-leucyl- norleucinal)、ALLM (N-acetyl-leucyl-leucyl-methiminal)、leupeptin (N-acetyl-leucyl-leucyl-arginal)為 Pgp的受質或抑制劑。本實驗以N-acetyl- leucyl-leucine為主架構，欲合成出一系列的線性peptide，有助於未來將此系列peptide應用於與Pgp間 interaction 的研究。
本實驗選用液態peptide合成法，合成出N-acetyl- leucyl-leucine benzyl、N-acetyl- leucyl-leucine、N-acetyl- leucyl-leucyl-tryptophanol、N-acetyl- leucyl-leucyl-CBZ-lysinol、 N-acetyl- leucyl-leucyl- phenylalaninol。

英文摘要
P-glycoprotein (Pgp), the multidrug resistance gene (mdr1) product, reduces the intracellular accumulation of a variety of drugs by pumping drugs out of membranes.
Studies have demonstrated that hydrophobic tripeptides N-acetyl- leucyl- leucyl-norleucinal (ALLN), N-acetyl- leucyl-leucyl-methiminal (ALLM) and N-acetyl-leucyl-leucyl-arginal (leupeptin) are Pgp substrates/inhibitors. We would like to synthesize a series of tripeptides (N-acetyl-leu-leu-X ) and to study the interaction between the tripeptides and Pgp.
We employ liquid-phase peptide synthesis method to obtain. We synthesize the N-acetyl-leucyl-leucine benzyl、N-acetyl-leucyl-leucine、N-acetyl-leucyl-leucyl-tryptophanol、N-acetyl-leucyl-leucyl-CBZ-lysinol、 N-acetyl-leucyl-leucyl-phenylalaninol.

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