金屬材料具有高機械強度、高韌性、抗疲勞強度、抗腐蝕性、可塑性、加工性與高經濟性等優點。目前常見的金屬生醫材料包含不銹鋼合金、鈷鉻合金、鈦系合金(TiO2)、貴金屬合金(Pt、Au)等，但是這些材料植進人體後，並不於人體內降解，等待復原後，視情況所需進行二次手術將材料去除。
因此，現在的趨勢是發展可降解金屬生醫材料，最大優點是可避免二次手術所造成的危險，這對於復原能力較差的患者很重要，也可避免植入永久植入材患者之後所需要的長期藥物控制。
本研究使用目前主流研究的可降解性金屬材料：鐵、鎂、鋅。此外，加入鎂鋰合金LA使其具有合金密度很低之比重（1.4 ~ 1.6 g/cm3），希望能夠將此合金應用於硬組織如骨頭上。目前可降解性金屬所需要的降解速率與上市材料相差過大，鐵的降解速率太慢，而鎂則太快。我們期許材料的降解速率與骨組織的成長能有一個好的控制。製程上，我們利用冷壓成形同時施加不同燒結熱處理及並探討鋰對於合金在燒結製程及性質上有何影響，經過不同製程處理後的微結構、測量腐蝕性質等，分析並歸納出成分、製程與性質之間關係，希望能提供後續可降解金屬植入材之研究參考。

Degradable metallic material is highly research because elderly patients are able to avoid the second surgery, while addressing the long-term implant material permanently implanted in the patient may be required, So we do our effort on the research of degradable material metallic.
In part 1, we use cold press to form the Fe-Mg-Li alloy sample and do different heat treatments of materials as the main object , compared by the composition, porosity, corrosion rate and microstructure. In part 2, we also use cold press to form the Fe-Zn-Mg-Li alloy sample and do different heat treatments of materials as the main object , compared by the composition, porosity, corrosion rate and microstructure.
In all of them, changing the composition and heat treatments change the properties obviously.

B. Heublein, R. Rohde, V. Kaese, M. Niemeyer,W. Hartung, and A. Haverich,Biocorrosion of magnesium alloys: a new principle in cardiovascular implant technology,Heart, 89(2003)651–656.
Chen Q, Liu L, Zhang S-M (2010) The potential of Zr-based bulk metallic glasses asbiomaterials. Front Mater Sci China 4:34–44
Chiba A, Lee S-H, Matsumoto H, Nakamura M (2009) Construction of processing map forbiomedical Co-28Cr-6Mo-0.16N alloy by studying its hot deformation behavior usingcompression tests, Mater Sci Eng A 513–514:286–293
Dalibor VOJTĚCH,Jiří KUBÁSEK,Jaroslav ČAPEK,Iva POSPÍŠILOVÁ,Magnesium,Zinc and Iron alloys for medical applications in biodegradable implants,Metal,2014
David R. Lide, CRC Handbook of Chemistry and Physics, CRC Press, 2003
G.G.Perrault,The potential-pH diagram of the magnesium-water system,Electroanalytical chemistry and interfacial electrochemistry,51(1974)107-119
H. Hermawan1, H. Alamdari1, D. Mantovani1 and Dominique Dube, Iron–manganese: new class of metallic degradable biomaterials prepared by powder metallurgy,2008
Habibovic P, Barrère F, Blitterswijk CAV, Groot Kd, Layrolle P (2002) Biomimetichydroxyapatite coating on metal implants, J Am Ceram Soc 83:517–522
Hendra Hermawan, Dominique Dube´, Diego Mantovani, Degradable metallic biomaterials: Design and developmentof Fe–Mn alloys for stents,Wiley InterScience,DOI: 10.1002/jbm.a.322t1, 2009
Hendra Hermawan,Biodegradable Metals From Concepts to Applications,Springer,2012
Hermawan H, Mantovani D, Degradable metallic biomaterials: the concept, currentdevelopments and future directions. Minerva Biotecnol 21:207–216, 2009
Hollander DA, von Walter M, Wirtz T, Sellei R, Schmidt-Rohlfing B, Paar O, Erli H-J,Structural, mechanical and in vitro characterization of individually structured Ti-6Al-4Vproduced by direct laser forming. Biomaterials 27:955–963, 2006
Hutmacher DW, Sittinger M, Risbud MV Scaffold-based tissue engineering: rationale forcomputer-aided design and solid free-form fabrication systems. Trends Biotechnol22:354–362, 2004
Institute of Medicine, Food and Nutrition Board. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zincexternal link disclaimer, Washington, DC: National Academy Press,2001
J. S. Hirschhorn, A. A. Mcbeath, M. R. Dustoor, Porous Titanium Surgical Implant Materials, Biomedical Materials Research Symposium, 1(1971) 49-67
John CW, Biocompatibility of dental casting alloys: a review. J Pros Dent 83:223–234, 2000
Johnson W, Bulk amorphous metal—an emerging engineering material. J Min Met MatSoc 54:40–43, 2002
Kuroda D, Niinomi M, Morinaga M, Kato Y, Yashiro T, Design and mechanical propertiesof new [beta] type titanium alloys for implant materials. Mater Sci Eng A t13:t14–t19, 1998
Lahann J, Klee D, Thelen H, Bienert H, Vorwerk D, Hocker H, Improvement ofhaemocompatibility of metallic stents by polymer coating. J Mater Sci Mater Med10:443–4t2, 1999
Lambotte A, Technique et indication des prothèses dans le traitement des fractures. PresseMed 17:321, 1909
Lane WA, Some remarks on the treatment of fractures, Brit Med J 1:861–863,1895
Lee SH, Nomura N, Chiba A, Significant improvement in mechanical properties ofbiomedical Co-Cr-Mo alloys with combination of N addition and Cr-enrichment. Mater Trans49:260–264, 2008
Li JP, Habibovic P, van den Doel M, Wilson CE, de Wijn JR, van Blitterswijk CA, de Groot K, Bone ingrowth in porous titanium implants produced by 3D fiber deposition.Biomaterials 28:2810–2820, 2007
Lopez-Heredia MA, Sohier J, Gaillard C, Quillard S, Dorget M, Layrolle P, Rapidprototyped porous titanium coated with calcium phosphate as a scaffold for bone tissueengineering. Biomaterials 29:2608–2615, 2008
M. Peuste,C. Hesse,T. Schloo,C. Fink,P. Beerbaum and C. Schnakenburg, Long-term biocompatibility of a corrodible peripheral iron stent in the porcine descending aorta, Biomaterials,27(2006)4955-4962.
Matsumoto H, Watanabe S, Hanada S, Beta TiNbSn alloys with low Young’s modulus andhigh strength. Mater Trans 46:1070–1078, 2005
Ryan G, Pandit A, Apatsidis DP, Fabrication methods of porous metals for use inorthopaedic applications, Biomaterials 27:2651–2670, 2006
Ryan GE, Pandit AS, Apatsidis DP, Porous titanium scaffolds fabricated using a rapidprototyping and powder metallurgy technique, Biomaterials 29:3625–3635, 2008
S. Rhalmi, M. Odin, M. Assad, M. Tabrizian, C. H. Rivard andL. H. Yahia, Bio-Medical Materials and Engineering, 9(1999)151–162.
Schroers J, Kumar G, Hodges T, Chan S, Kyriakides T, Bulk metallic glasses forbiomedical applications. J Min Met Mater Soc 61:21–29, 2009
Sherman WO, Vanadium steel bone plates and screws, Surg Gynecol Obstet 14:629–634, 1912
Stack RS, Califf RM, Phillips HR, Pryor DB, Quigley PJ, Bauman RP, Tcheng JE, Greenfield JCJr ,Interventional cardiac catheterization at Duke Medical Center. Am J Cardiol 62:3F–t1F, 1988
T. F. Volynova, I. B. Medov,and I. B. Sidorova ,Mechaicalproperties and the fine structure of powdered Iron-Manganese alloys,Powder Metallurgy and Metal Ceramics,25(1986)999-1006
Wang YB, Zheng YF, Wei SC, Li M, In vitro study on Zr-based bulk metallic glasses aspotential biomaterials. J Biomed Mater Res B 96:34–46, 2011
Xue-Nan Gu,Yu-Feng Zheng,A review on magnesium alloys as biodegradable materials,Frontiers of Materials Science,4(2010)111-115
Yang K, Ren Y, Nickel-free austenitic stainless steels for medical applications. SciTechnol Adv Mater 11:1–13, 2010
Y-H.Li, G-B. Rao, L-J.Rong, Y-Y. Li and W.Ke, Effect of Pores on Corrosion Characteristics of Porous NiTi Alloy in Simulated Body Fluid,Materials Science and Engineering A, 363(2003) 356-359
Zberg B, Uggowitzer PJ, Loffler JF, MgZnCa glasses without clinically observablehydrogen evolution for biodegradable implants. Nat Mater 8:887–891, 2009
H. Takuda, H. Matsusaka, S. Kikuchi, K. Kubota，Tensile properties of a few Mg-Li-Zn alloy thin sheets，2002
Zhong, H., Liu, P. , Zhou, T., Li, H. ，Design of an age hardening Mg-Li alloy and its aging behavior
ASM Speciality Handbook, “Magnesium and Magnesium Alloy s”,ASM International，1999
S.K. Wu, J.Y. Wang, K.C. Lin, H.Y. Bor，Effects of cold rolling and solid solution treatments on mechanical properties ofβ-phase Mg–14.3Li–0.8Zn alloy，1971
王繼敏,不鏽鋼與金屬腐蝕,科技圖書股份有限公司,p.136-156,1990
宋信文,生醫材料簡介,2003
李岳霖, 鐵/鋅複合材料製程、結構及性質研究, 國立成功大學碩士論文, 2014
汪建民,材料分析,中國材料科學學會, 1998
汪建民,粉末冶金技術手冊,中華民國粉體及粉末冶金協會,1994
徐仁輝,粉末冶金概論,新文京開發出版有限公司, 2002
高材,林康平,林峰輝,陳家進,生物醫學工程導論,中華民國生物醫學工程學會,2008
國人膳食營養素參考攝取量,第六版,2003
趙長生,生物醫用高分子材料,化學工業出版社,2009
大島宣雄，生物醫學工程概論 : 支援醫學的工程學，2012
王正一，醫學工程原理與應用，1996