本文首先以單鏈不同鏈長的陽離子界面活性劑（十碳至十六碳）和陰離子界面活性劑（十二碳至十六碳）為材料，運用沉澱法及離子交換法製備九種雙鏈的陰陽離子界面活性劑（catanionic surfactant），並鑑定其結構和化學式。此外，亦使用差示掃描熱卡計（differential scanning calorimetry, DSC）量測陰陽離子界面活性劑雙層膜結構由凝膠相（Lβ , Pβ）至液晶相（Lα）的相轉移熱力學性質。實驗結果顯示，其中四種IPA會有前相轉移吸熱峰的產生，而在主要相轉移吸熱峰方面，基本上總碳數較長的陰陽離子界面活性劑會有較高相轉移溫度，但相轉移焓及熵則沒有一定的趨勢。添加膽固醇於其中兩種陰陽離子界面活性劑（DTMA-DS、HTMA-DS）時則發現：膽固醇可有效降低相轉移焓及熵但幾乎不改變相轉移溫度，當膽固醇超過一特定添加量之後，則相轉移的現象會消失。此一現象，與DTMA-DS是否能形成液胞有關，但與HTMA-DS則無關。

The ion pair amphiphiles can be prepared by two surfactants: cationic surfactant (the hydrocarbon chain is from 10 to 16 atoms,) and anionic surfactant, (the hydrocarbon chain is from 12 to 16 atoms,) and the ion pair amphiphiles can be prepared by two different methods, precipitation method and ion-exchange method. From instrument analysis, we can identify the chemical structure and formula. Moreover, using the differential scanning calorimetry to measure the thermotropic transition behavior from gel state to liquid-crystalline state. From the result, basically, when the sum of hydrocarbon chains is higher, the phase transition temperature is higher, but the phase transition enthalpy and entropy is not. When adding cholesterol into DTMA-DS and HTMA-DS, the phase transition enthalpy and entropy will decrease, but phase transition temperature is still constant. When the amount of cholesterol go beyond specific capacity, the phase transition behavior will disappear. This phenomenon can be related to the formation of vesicles with DTMA-DS, but has nothing to do with the formation of vesicles with HTMA-DS.

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相關網頁 : (台灣微脂體公司) http://invest.taipei.gov.tw/data/96_1_2.pdf