近年來，第三生物視窗於生物醫學掀起一陣旋風，因其不易被生物組織散射具有高穿透深度之優點，可以抵達生物體更深層組織，因此被廣泛地應用於生物影像。
本研究設計以二氧化矽包覆 NaYF4:Er@NaYF4 和碳六十的奈米粒子。NaYF4:Er@NaYF4 上轉換奈米粒子中的 Er3+ 同時作為吸光體 和放光體，可吸收第三生物視窗中的1550 nm波段，產生多波長之放光，進而結合高單態氧產率的碳六十，並包覆上二氧化矽。藉由上轉換奈米粒子 (提供者) 和碳六十 (接收者) 之間的螢光共振能量轉移可產生大量之單態氧，未來則可應用於光動力治療。

In recent years, the third biological window (NIR-III: 1500-1800 nm) has drawn much attention and been widely used in imaging applications as for its deep penetration depth into biological tissues.
In this work, we present a silica coated NaYF4:Er@NaYF4 upconversion nanorods and fullerene (CS-UCNRs, C60@SiO2) . Er3+ is both served as sensitizer and emitter aiming to harvest pump at 1550 nm and promote multiple emission bands. The singlet oxygen generation yield can even achieve 100% in combination with fullerenes. Based on Förster resonance energy transfer (FRET) in which UCNRs as donors and fullerene as acceptors, further promote the singlet oxygen generation yield facilitating the application to photodynamic therapy.

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