背景:愛滋病毒感染者的負擔加重和早發使身體虛弱成為嚴重的公共衛生問題。愛滋病毒 感染者 (PLWH) 合併衰弱 會經歷更嚴重的負面後果，如提昇死亡率和發病率。量化愛滋 病毒感染者其衰弱盛行率的影響有其必要性。然而，調查成人愛滋病毒感染者虛弱全球盛 行率之相關研究有限, 且對於愛滋病毒者於哪個年齡區段是高風險發生衰弱仍不清楚。
目的:本研究旨在調查 HIV 感染成人患者衰弱的患病率和發病年齡。
方法:本研究採用了系統性回顧與薈萃分析設計。資料庫檢索在 OVID Medline、CINHAL、 Embase、Scopus 和 Web of Science 中進行 2013 年至今出版 ，以搜尋包括成人愛滋病毒族群的觀察性研究。總體衰弱的盛行率是透過隨機效應薈萃分析2得出的。進一步進行了亞組分析。
结果:從最初資料庫檢索的 4399 項研究中，最後分析納入了 80 項研究，總計 68579 名成 年人愛滋病毒感染者。這些研究於 2013 年至 2024 年進行。研究之間的異質性很高 (I2=99%)。亞組分析探討了人口統計變量，顯示整個亞組始終存在高度異質性(I2= 92%-99%，p<0.0001)。愛滋病毒感染者開始衰弱的年齡是三十多歲。
結論: 感染愛滋病毒的成年人中 10% 的人出現虛弱症狀，且相較一般族群，早在三十多歲就開始發病。對感染愛滋病毒的成年人的虛弱總體盛行率進行了調查。這篇綜述量化了成人愛滋病毒感染者的衰弱負擔，並揭示了衰弱的發病年齡。需要進一步研究透過適合年齡的有針對性的干預措施來解決愛滋病毒人群的過早衰弱問題。

Background: The heightened burden and premature onset in the HIV population renders frailty a serious public health concern. People living with HIV (PLWH) experience exacerbated negative outcomes including increased mortality and morbidity due to frailty. Prevalence is necessary in quantifying the impact of frailty within the HIV population. However, there are limited broad studies investigating the overall prevalence of frailty in adults living with HIV. The earliest age for frailty in the HIV population remains unknown.
Aim: This study aimed to investigate the prevalence and earliest age of frailty in adults living with HIV.
Methods: A systematic review and meta-analysis design was used in this research. Database searches were conducted in OVID Medline, CINHAL, Embase, Scopus, and Web of Science to search for observational studies published from 2013 to the present, that include adult HIV populations. The overall prevalence of frailty was generated by random-effects meta-analysis. Subgroup meta-analyses were further conducted.
Results: Of the 4399 studies from the initial database search, 80 studies were included in the analysis, with a sum of 68 579 adults living with HIV. These studies were produced from 2013 to 2024. The overall prevalence of frailty was 10% (95% confidence interval [CI], 8%-12%). Heterogeneity across studies was high (I2=99%). The subgroup analysis explored demographic variables, illustrating high heterogeneity consistently throughout subgroups (I2= 92%-99%, p<0.0001). The earliest age of frailty in individuals living with HIV is their forties.
Conclusions: 10% prevalence of frailty among adults living with HIV, with frailty occurring as early as their forties. This review quantified the frailty burden in the adult HIV population and uncovered the earliest age of frailty. Further research is needed to address premature frailty in the HIV population through age-appropriate targeted interventions.

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