目的：Beck(1967, 1979) 認為負向自我基模為憂鬱症之脆弱因子，過去針對憂鬱症患者之研究雖然發現憂鬱症患者與憂鬱症緩解病患其自我基模較正常人負向，但無法釐清負向自我基模究竟是憂鬱症之病因或是憂鬱症所帶來的後果。過去研究發現憂鬱症母親其子代亦有較高機會罹患憂鬱症，為憂鬱症之高危險群，且其患病之機制可能與母親類似，因此若在憂鬱症高危險群身上發現負向自我基模，則負向自我基模便可能是憂鬱症之脆弱因子。而過去理論與實徵研究又支持自我基模需要被負向情緒促發下才會顯現出來。因此，本研究旨在驗證在悲傷情緒引發下，憂鬱症母親其子代之自我基模是否較一般兒童負向。本研究另一目的為驗證兒童(無論高危險群或是控制組)之負向自我基模是否可以解釋兒童之憂鬱症狀。

方法：樣本為51對曾罹患憂鬱症之母親與其子代，並以54對未曾罹患精神疾病之母親與子代作為控制組。兒童於實驗室分別於悲傷以及中性情緒引發程序下進行Self Referent Encoding Task (SRET) 以評估自我基模，SRET包括對形容詞的評定與回憶兩部分，評定部分用來估計兒童之自我概念，而回憶部分則反應出兒童之自我基模對訊息之處理傾向。並以兒童行為與情緒量表與貝氏憂鬱量表分別評估兒童與母親之憂鬱症狀，量表部分交由受試者回家填寫後寄回。
結果：主要發現有三: (1) 在悲傷情緒引發後，悲傷情緒被成功引發之受試者較中性情緒下評定更多的負向詞為符合對自己的描述。 (2) 無論情緒引發之種類，憂鬱症母親其子代較控制組更傾向去回憶負向的形容詞。 (3) 無論兒童之組別，在中性情緒下對負向詞的評定可顯著解釋兒童之憂鬱症狀。

結論：憂鬱症母親其子代較一般兒童傾向去處理負向的訊息，表示他們可能具有較負向之自我基模，可能使得他們將來有較高的機會罹患憂鬱症。而無論兒童為高危險群或是控制組，在成功之悲傷情緒引發後兒童之自我概念較中性情緒下更為負向，顯示兒童之自我基模確實會受到悲傷情緒促發而表現之。兒童在中性情緒下其自我概念越負向，將來越可能有較高的憂鬱症狀。

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