在過去十年以來，由於蛋白質包覆的金奈米團簇具有優異的光穩定性以及良好的生物相容性，因此在醫學和奈米生物技術領域中備受關注，且也被廣泛應用於物質的檢測，而在本研究中，我們以光穩定、無毒以及具有紅色螢光放射的牛血清蛋白包覆金奈米團簇 (BSA-AuNCs) 選擇性的檢測兒茶酚類似物質。
首先我們利用螢光光譜儀、UV吸收光譜儀、MALDI-TOF質譜儀以及XPS對於合成後的BSA-AuNCs進行光學性質、質量及組成型態的鑑定，以確認BSA-AuNCs的形成，合成後的BSA-AuNCs整體質量大約為71 kDa，且具有635nm的螢光放射。
實驗將兒茶酚類似物以鐵 (III) 離子氧化為鄰苯醌後與BSA-AuNCs反應，並觀察到了其螢光的淬滅，並藉由測量其螢光淬滅及UV吸收，可以選擇性的偵測兒茶酚類似物，再來我們更以蛋白質體學中由下而上的水解酵素法分析樣品，推測造成BSA-AuNCs螢光淬滅的原因主要來自氧化後的兒茶酚類似物與金團簇核心附近的BSA基板之間的親和作用力，進而發生金團簇螢光與兒茶酚類似物-鐵(III)錯合物及鄰苯醌之間的螢光共振能量轉移 ( FRET ) 和電子轉移 (Electron transfer)效應，造成螢光的淬滅。此檢測系統具有應用於真實樣品的可行性，在未來我們欲將其用於偵測茶葉中的兒茶素或添加於食用植物油中的沒食子酸丙脂。

In the past decade, protein-protected gold nanoclusters have attracted much attention in the fields of medicine and nanobiotechnology due to their excellent photostability and good biocompatibility. It also was widely used in sensing applications. In this study, we utilized the fluorescent gold nanocluster synthesized by bovine serum albumin to detect catechol analogues.
We found that the red fluorescence of BSA-AuNCs was quenched by catechol analogues after adding iron (III). This sensing system can selectively detect the catechol analogues by measuring the fluorescence quenching and UV absorbance.
BSA-AuNCs reacted with oxidized catechol analogues were then analyzed by proteomics-based mass spectrometry techniques. It is speculated that the mechanism for the fluorescence quenching of BSA-AuNCs is mainly due to the fluorescence resonance energy transfer (FRET) between Au core and catechol analogues - iron(III) complex, and electron transfer effect between Au core and catechol quinone. We expect our developed sensing system could be applied to real samples, such as catechins in tea or propyl gallate in vegetable oil.

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