本研究使用對環境友善之有機模板合成具有高比表面積的孔洞氧化矽材料，並依
據孔洞氧化矽材料的孔洞可調性，分別運用於音響材料及牙根尖周炎填充材料中。在
音響材料方面，藉孔洞氧化矽之孔洞使聲音進入孔洞後可減少高音頻之建設性干涉，
突顯低頻，改善音質；在孔洞材料合成時，藉由控制水熱時間將孔徑控制於微孔尺度
下，之後引入對同樣環境友善之海藻酸鈉作為黏著劑進行造粒，以利置入微型音箱中
進行共振頻率測試。實驗結果顯示，由於海藻酸鈉在造粒過程中會堵塞孔洞使共振頻
率提高，因此需對造粒製程上做些微調整。其中，若將孔洞氧化矽材料與作為孔洞保
護劑之矽凝膠混合再進行造粒可使共振頻率下降約 62 赫茲。除添加保護劑外，本實
驗亦嘗試使用鋁離子異相成核作為鍛燒移除有機物後之無機黏著劑，雖然經過高溫鍛
燒後可使造粒承受力提高至 1 公斤，但在頻率測試中，其共振頻率下降不顯著。本實
驗於最後對於各種影響共振頻率之因素進行排序，由大至小分別為:有機物含量、親
疏水性、孔洞大小，此外，機械強度也必須兼顧。另一方面，本實驗將孔洞氧化矽材
料之孔洞擴大至中孔，並與硝酸鈣混合後高溫鍛燒形成具有二鈣矽酸鹽與三鈣矽酸鹽
之三氧礦化物(MTA)，用於牙根填補材料。實驗中也使用不同構型之囊泡狀孔洞氧化
矽進行合成，可得到三鈣矽酸鹽占比更高之三氧礦化物；實驗最後將材料固化後浸泡
模擬體液探討其反應機制，也針對硬度進行機械強度壓強測試，其中，以囊泡狀中孔
洞二氧化矽為氧化矽源，並以鈣矽比 3.0 之參數所固化後的錠片可承受力最高，可達
與市售 MTA 相同受力 7 公斤。

In this study, micropore and mesopore were synthesized by soft template method with different templates and used in different fields. Microporous silica was applied to acoustic material and placed in phone speaker to reduce the sound frequency. And, mesoporous silica was used as the base for dental root-end filling material.
In acoustic materials, current studies show that microporous materials have good
performance, but it needs complicated synthesis steps and is highly-priced. This study provided a simple and cheap method to synthesize microporous silica. Besides, granulation by gelation of alginate was introduced to the procedure for the transforming from powder to granules. However, the material after granulation was hydrophilic, and the mechanical strength was poor. To improve the hydrophobicity and mechanical strength, many different methods were introduced to improve and test their effects. The whole process gave the advantages including greatly reducing water adsorption, highly increasing mechanical strength, and completely removing organic matters. In the frequency test, the best parameters of the granulation had a resonant frequency drop of about 62 Hz. As for dental root-end fill materials, the material mainly used is mineral trioxide aggregate (MTA) extended by Portland Cement as the main component. MTA has the characteristic
of hardening in water, so it is very suitable for use in surgery. Besides, MTA is highly
alkaline, antimicrobial, and biologically active, so it can affect the oral environment, and promote the formation of dentin. The biggest problem with commercial MTA is the heavy metal content from the extracted raw materials. Although there is still no pathogenicity of these heavy metals literately, the hematoxylin may react with them and stain the dentin. Therefore, other research has tried to synthesize MTA materials themselves. However, these synthetic steps may require the addition of organic solvents, be too complicated, or have a high risk. In this study, a simple and safe process for the synthesis of MTA was introduced by physically mixing calcium nitrate and mesoporous silica with water. The heavy metal-free product was obtained after removing water and calcination. Products were analyzed by XRD and immersed in simulated buffer fluid (SBF) solution for testing.

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