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研究生: 連志浩
Lien, Chih-Hao
論文名稱: 目標與分心刺激之fMRI重複抑制
fMRI Repetition Suppression for Targets and Distractors
指導教授: 林君昱
Lin, Chun-Yu
學位類別: 碩士
Master
系所名稱: 社會科學院 - 心理學系
Department of Psychology
論文出版年: 2016
畢業學年度: 104
語文別: 中文
論文頁數: 149
中文關鍵詞: 重複抑制注意力功能性磁振造影(fMRI)
外文關鍵詞: Repetition Suppression (RS), attention, fMRI
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  • 重複抑制(Repetition Suppression, RS)是指當重複看到相同的刺激,或是重複進行相同反應時,相關腦區之活化程度會顯著下降的現象。目前對於重複抑制是否是個自動化的現象或為一種需要投入注意力參與的歷程,仍是有所爭議。例如Jiang et al.(2000)呈現一連串臉孔,要求參與者對與樣本刺激相同的目標刺激進行反應,發現參與者對於重複出現的目標刺激(需要注意)與分心刺激(不需注意)皆呈現重複抑制,支持重複抑制是自動化現象的觀點。但Chun與Yi(2005)同時呈現疊合的(composite)風景與臉孔兩種刺激,要求參與者根據線索注意風景或臉孔中的一種是否改變,卻發現只有在初次出現與再次出現時皆是需注意的目標種類時,才會在對應腦區出現重複抑制,支持重複抑制需要注意力投入的看法。本研究欲檢驗對於目標與分心刺激所需要的不同注意程度,是否會影響重複抑制的產生與否。我們以Jiang et al.(2000)的實驗派典為基礎,並搭配Chun與Yi(2005)採用風景、臉孔兩種刺激的設計來進行修改,藉由目標刺激與分心刺激的種類變化進行注意力的操弄,以釐清注意力的投入與重複抑制之間的關聯。結果顯示不論分心刺激的種類與目標刺激相同與否,參與者對於重複出現的分心刺激皆會呈現重複抑制,支持重複抑制是一種自動化歷程的觀點。

    Repetition Suppression (RS) refers to the phenomenon that when the same stimulus is repeated, the BOLD responses to it decrease in certain brain areas. It reminas unclear what exactly its underlying neural mechanism is. One theory suggests that RS is a perceptual-level automatic process; therefore it should remain the same regardless of attentional or task demand manipulations (e.g., Jiang et al., 2000). However, there are also several studies reported a different pattern suggesting that RS is not an automatic process and can be modulated by attention (Yi & Chun, 2005). One reason that why previous studies have yield different results might be the differences in the level of attention to the stimuli manipulated in those studies.
    We reckon that when targets and distractors belong to very different categories, the distractors can be ignored immediately after the stimulus category is identified, thus receives minimum attention. And this may not be enough to produce RS (e.g., Yi & Chun, 2005). We modified the paradigm Jiang et al. (2000) used, adding a manipulation of using two categories of stimuli (face and scene), to investigation our hypothesis. The results indicate that RS can be found in stimulus-category related areas (ie. parahippocampal place area and fusiform face area) in all four conditions regardless of whether targets and distractors were from same category or not. In sum, our results support better the view that RS is an automatic process, at least in the paradigm we used.

    第一章 緒論 1 第一節 重複抑制 2 第二節 促發 4 第三節 重複抑制的發展與證據 6 第四節 fMRI適應 9 第五節 重複抑制與注意力間的爭議 10 觀點一:重複抑制為自動化歷程,不受注意力影響 12 第六節 研究問題與假設 28 第二章 實驗方法 38 第一節 實驗參與者 39 第二節 實驗刺激 39 台灣人基本情緒及衍生情緒之表情 40 台灣人臉資料庫(Taiwanese Facial Expression Image Database,TFEID) 40 Postech Faces ’01 (PF01) 41 標準化刺激銀行(Bank of Standardized Stimuli, BOSS) 42 第三節 實驗工具與儀器設備 42 一般性統計分析軟體 42 fMRI 資料分析軟體 42 磁振造影影像之取得 43 第四節 工作記憶作業(working memory task) 44 第五節 功能性定位掃描作業(functional localizer task) 46 第六節 再認作業(Recognition Task) 48 第七節 功能性磁振造影影像資料分析方式 50 功能性磁振造影影像資料前處理 50 功能性磁振造影影像資料分析 51 ROI定義 53 第三章 結果 54 第一節 行為資料分析 55 工作記憶作業 55 再認作業 71 第二節 影像資料分析 78 功能性定位掃描作業 78 ROI分析 79 FFA與PPA對四種情境的整體反應樣式 86 全腦分析(whole-brain analysis) 94 第四章 討論 104 第一節 重複抑制為自動化歷程,不受注意力影響 105 第二節 兩種分心刺激的活化反應與樣式具有相似性 106 第三節 注意力影響重複抑制的關鍵在於處理到資訊? 109 第四節 對整體活化樣式相似性的解釋 112 第五節 重複增強的解釋 113 第六節 FFA牽涉其他的歷程? 117 第七節 本研究之貢獻 119 使用兩種差異較大的刺激 119 統一臉孔刺激的方向 120 刺激中刺激重複次數較多 120 嘗試次數與內含刺激數量較少 121 固定目標刺激與兩種分心刺激的數量 122 不重複使用刺激 123 改變刺激的呈現方式並讓相同刺激可以連續呈現 124 兩種分心刺激採用相同種類的刺激 124 檢驗非重複呈現分心刺激的活化樣式 125 集中關注FFA與PPA兩處ROI 126 完全分離呈現四種情境的結果 127 第八節 研究限制 128 參與者會被動觀看刺激 128 嘗試次次數較少 129 刺激之間的細微差異 129 第九節 未來研究展望 130 降低參與者負擔 130 檢驗重複抑制與注意力之間的關係 131 第十節 總結 133 附錄一:各參與者的ROI座標與圖示 143 附錄二:各參與者進行工作記憶作業之情形 149

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