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研究生： 洪聖翔
Hung, Sen-Hsiang
論文名稱： 硫酸鈣/磷酸鈣複合材骨水泥性質研究(I)
Investigation of Properties of Calcium Sulfate/Calcium Phosphate Composite Cement (I)
指導教授： 陳瑾惠
Chern Lin, Jiin-Huey
共同指導教授: 朱建平
Ju, Chien-Ping
學位類別： 碩士
Master
系所名稱： 工學院 - 材料科學及工程學系
Department of Materials Science and Engineering
論文出版年： 2010
畢業學年度： 98
語文別： 中文
論文頁數： 117
中文關鍵詞： 複合材骨水泥
外文關鍵詞： CBC
相關次數： 點閱：80  下載：0 
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    • 磷酸鈣骨水泥具有優良的生物相容性與適當的機械強度，並具有骨傳導性，但在人體內吸收速率相當慢使得骨細胞不易取代；而硫酸鈣骨水泥在體內溶解速率快，溶解的同時釋出鈣離子，鈣離子的釋出使得材料具有誘骨性，且硫酸鈣也具有良好的生物相容性；因此磷酸鈣和硫酸鈣混合後，利用硫酸鈣快速被吸收當作製造骨基質原料及產生空洞效果的特性，有利於新骨長入。
    本實驗選用91CBC、81CBC與82CBC三種不同比例的複合材骨水泥進行生物體外的短時間以及長時間的機械性質與其他物理性質之研究與探討。
    CBC添加少量的A能具有一定的抗壓強度，且能在骨水泥中產生許多孔隙；此外，A不會產生毒性，對於骨細胞的生長與支撐具有一定的效果。

    Calcium phosphate cement has excellent biocompatibility and adequate mechanical properties. It has also shown osteoconductive but has slow resorption in the human body. Calcium sulfate is a kind of materials that has excellent biocompatibility and fast resorption in human body. When calcium sulfate dissolved, the calcium ion was released that makes calcium phosphate composite with osteoinductive property. The absorpted calcium sulfate will be used as materials of bone matrix. It will make porous effect in composite. The newly formed bone integrates into the implant along with the pore and contacts directly with crystals of calcium phosphate.
    The present work is a study of three kinds of composite bone cement:91CBC、81CBC and 82CBC soaking in Hanks’ solution with short period and long period of mechanism, mechanical properties and physical properties in vitro.
    The composite cement added A has good compressive strength and get porosity in bone cement. Besides,A is non-toxic and has effect on the growth and support of bone cells.

    中文摘要 I Abstract II 誌謝 III 目錄 IV 圖目錄 VIII 表目錄 XIII 第一章 總序論 1 1-1生醫植入材料分類及發展簡介 1 1-1-1生醫材料的定義 1 1-1-2生醫材料的分類： 2 1-1-3生醫材料發展簡史： 7 1-2 生醫陶瓷 11 1-3 人體硬組織成份與性質簡介： 14 1-4生醫骨科人工植入材料所需具備的條件 20 1-4-1骨取代物在生物學上的要求： 21 1-4-2骨取代材料性質與製程的要求 21 第二章 文獻回顧 23 2-1 生醫陶瓷之骨取代材 23 2-1-1 生物活性與結構型態間之相關性 24 2-1-2可吸收性生醫陶瓷 25 2-2硫酸鈣的歷史回顧與性質簡介 29 2-2-1 硫酸鈣的歷史回顧與發展 29 2-2-2 硫酸鈣的性質簡介 30 2-3磷酸鈣的性質簡介與發展 34 2-3-1鈣磷系生醫陶瓷的性質與分類 34 2-3-2雙相磷酸鈣骨水泥 36 2-3-3 磷酸鈣骨水泥的優點與缺點 37 2-4磷酸鈣鹽類與硫酸鈣鹽類形成之多相複合生醫材料 42 2-4-1 CaSO4･ 1/2H2O/ HA composite 43 2-4-2 CaSO4･ 1/2H2O/α-TCP composite 45 2-4-3 CaSO4･2H2O/α-TCP composite 47 2-5研究目的 55 第三章 實驗原理及步驟 56 3-1 實驗使用藥品 56 3-2 機械性質實驗步驟與分析方法 56 3-2-1CBC複合材粉末製備 56 3-2-2 抗壓試片製作與強度測試 57 3-2-3 工作與硬化時間測量 57 3-2-4 pH值的量測 57 3-2-5 X-Ray diffraction （XRD）分析 59 3-2-5 Scanning Electron Microscopy（SEM）表面觀察 60 3-2-6細胞毒性測試 61 3-2-7 重量損失 61 3-2-8孔隙率量測 61 第四章 結果與討論 69 4-1 不同種類的CBC以不同比例混合添加不同濃度硬化劑間之浸泡Hanks’ solution一天後機械性質測量： 69 4-1-1 CBC以不同比例混合之複合材抗壓強度： 69 4-1-2 CBC以不同比例混合之複合材工作時間與硬化時間： 71 4-2複合材骨水泥初始反應情況： 75 4-2-1 複合材骨水泥以定濃度及L/P ratio硬化劑混合後浸泡Hanks’ solution短時間之機械性質測量： 75 4-2-2 複合材骨水泥以定濃度及L/P ratio硬化劑混合後短時間pH值量測： 76 4-2-3 複合材骨水泥以定濃度及L/P ratio硬化劑混合後注射性質： 77 4-3複合材骨水泥長時間浸泡Hanks’ solution之結果討論與分析： 84 4-3-1 複合材骨水泥以定濃度及L/P ratio硬化劑混合後浸泡Hanks’ solution長時間之抗壓強度： 84 4-3-2 複合材骨水泥以定濃度及L/P ratio硬化劑混合後浸泡Hanks’ solution長時間之pH值： 86 4-4 細胞毒性測試 92 4-5 XRD分析 94 4-6 SEM分析 98 4-7 重量損失 106 4-8 孔隙率 108 結論 110 參考資料 112

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