皮膚磨潤學的研究可以有效的模擬現實生活中人體皮膚與各種材料表面的接觸，與皮膚的健康、穿戴、抓握舒適性息息相關。以工程材料角度來看，皮膚可視為一種功能梯度材料，具備多層結構、非均質性、非線性彈性、非等向性、黏彈性等機械性能。
本研究主要使用專為軟材料開發的多功能軟組織摩擦磨損試驗機(UMT-2)進行摩擦實驗。一般皮膚摩擦研究多以探討完整正常的皮膚為主，在本文中針對人體手臂皮膚進行摩擦實驗，並且經由膠帶逐層撕除皮膚表層角質細胞層後，探討負載與摩擦速度改變後，對皮膚摩擦係數的影響。由於人體體表皮膚容易因為劇烈刮傷、深層去角質或是貼布等而使上層角質脫落，經由膠布定量移除的方式能夠有效定量角質層移除量，進而提供探討不同角質移除造成皮膚摩擦行為的變化。
由於上層角質為片狀無核死細胞，藉由膠布針對同一部位進行逐次的撕除，經量測吸光值計算移除角質層重量及移除厚度，可以得知隨移除次數增加，皮膚內層角質鍵結能力漸強，使得移除的數目會逐次減少，並量測經皮水分散失也可得知當皮膚角質移除後，經皮水分散失會逐漸升高，使用簡單的壓痕實驗觀察可得，隨逐次移除角質，皮膚剛性逐漸變小，皮膚處於較軟的狀態下容易使探頭與皮膚間接觸面積增加，進一步探討與分析在不同程度的破壞下，對皮膚表層的磨潤性質所造成的影響，可以作為未來研究受創傷或脫皮狀態下皮膚摩擦係數以及舒適性的重要參考依據。

Recently, more and more people study skin tribology because this topic is related to our daily life and it can simulate the friction property between skin and other materials. Once we move, the skin friction will connect with the heath of our skin, the clothes we wear or even the tools we hold. From the point of view of Engineering Materials, the skin can be regarded as a functionally graded material which different to other hard materials, it has multi-layers and can be considered as non-homogeneous, nonlinear elastic, anisotropic, viscoelastic material properties.
In this study, the Universal Nano + Micro + Macro Materials Tester-2 (UMT-2) which is designed for soft material is used to realize the friction experiments. Until now, researchers focus on the friction property of normal and healthy skin. Here we use our forearm skin to realize the friction experiments both before and after tape stripping and discuss the difference under different condition including different load and velocity. It takes a series of tapes to remove the stratum corneum on the skin surface. Because the human skin is easily damage by severe scratches or deep exfoliating, they will cause the stratum corneum being removed from our intact skin. Here we use tape stripping to quantitative the amount of stratum corneum we removed and analysis how the friction coefficient change when stratum corneum was removed.
Since the upper stratum corneum is dead cell, the spectrum was measured and their absorbance and pseudo-absorbance was calculated into the mass of stratum corneum we removed. The more tape-stripping we do, the less stratum corneum being removed because that the bonding between deeper stratum corneum is stronger than the upper part and will cause the value of trans-epidermal water loss grow higher. We also found out that our skin stiffness will decline with more and more stratum corneum being removed. In this condition we can let the skin getting softer and the contact area will increase, thus cause the friction increase. Here we analyze the tribological properties of the skin surface under different degrees of damage, and we hope that this research can be seen as important reference for those who study skin friction that have trauma or get injuries.

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