血液凝固由於反應複雜、參與反應的凝血因子很多，故臨床上可用以檢測肝臟的功能，但傳統上，血液凝固實驗須仰賴大型之離心機與血液分析儀，故只能在實驗室進行且耗時故不利於臨床應用。實驗室晶片(Lab on a chip)係指一可將傳統複雜實驗整合在同一晶片中，以減少實驗所費之時間與成本之晶片，本研究設計一可用於血液凝固檢測之實驗室晶片，期以改善傳統的血液凝固實驗費時且不易於臨床應用之缺點，透過非接觸式之電容感測，本晶片提供一可量化之數據作為準則，亦可減少血液樣本因接觸各種感測器而在量測過程中變質產生誤差，且在晶片驅動與方面，本研究成功利用毛細力來驅動高黏度之血液而不需任何外加驅動源或裝置，故在未來與其他裝置進行整合時將有更大的優勢，應用更多元。
由實驗結果可知，此一晶片有良好的自驅動能力，在注入血液80分鐘後可觀察到血液完全的流過晶片流道，透過量化分析與線性回歸，我們定義了晶片的規格，並發現此一晶片有良好的重現性，電容掃頻圖僅有2.0-3.0 pF的誤差。我們探討了晶片在不同頻率下血液與電容的關係，並發現在不同的頻率下，血液的電容變化約為0.5-2.0 pF，符合理論電容值1.8 pF，並且此關係曲線媒合之結果與理論推導中之結果一致，最後我們將此一晶片的測得之凝固時間(Clotting time, CT)與血液凝固分析儀CA-50測得之活化部分凝血活酶時間(Activated partial thromboplastin time, aPTT)做比較，我們發現90%電容值下之凝固時間，有非常高的相關係數0.9084。這些結果驗證了電容非接觸式微流體血液晶片可確實用於血液凝固檢測當中，最後若能將此電容晶片整合其它應用則將可使此晶片有更好的發展。

Because of the complex reaction path and various blood coagulation factors, the blood coagulation dection can be used in understanding the function of liver. But, the blood coagulation test is usually performed by a relatively large centrifuge in the laborary traditionally and unfavorable to clinical application. Lab on a chip is the kind of chip integrating the many processes into one chip in order to reduce the cost and time of production and experiment. In this study, we design the lab on a chip using in the blood coagulation detection in order to improve the weakness of clinical application and reduce the experiment time. Although the capacitively coupled contactless conductivity detection, our chip can offer the standard value from quantifiable data and also reduce the error of blood sample because of the contacting with senor during the measurement. In the driving blood respect, we succeeded in using the capillary force to drive the blood in the channel without any external driving resource. So, it’s much potential to apply to integrate with the other device
From the results, we found the great self-driven ability of chip. At the 80TH minute after injection, we can observe blood completely flow through the channel of the chip. By quantitative analysis and linear regression, we also defined the specification of the chip. The chip presented low error, 2.0-3.0 pF, and great repeatability. The relationship between blood and capacitance in the various frequencies has been discussed. We found the the capacitance change of the blood in the chip is about 0.5-2.0 pF closing to the theory value 1.8 pF and the fitting result of the relationship between time and capacitance is similar to the result of theory. Finally, through comparing with the CT (Clotting time) of microfluidic chip and aPTT (Activated partial thromboplastin time) determined form blood coagulation analyzer CA-50, we found the R square is pretty high equal to 0.9084 at the CT of 90 percent capacitance. These results show the characteristic and feasibility of blood coagulation detection in the capacitive capillary chip. In the future, it’s no doubt that this chip can be integrated with the other devices in order to apply in various fields.

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