| 研究生: |
簡清富 Chien, Ching-Fu |
|---|---|
| 論文名稱: |
運動素於外加力負載下之運動分析 The analysis of the motion of kinesin with external load |
| 指導教授: |
黃明哲
Huang, Ming-Jer |
| 學位類別: |
碩士 Master |
| 系所名稱: |
工學院 - 工程科學系 Department of Engineering Science |
| 論文出版年: | 2003 |
| 畢業學年度: | 91 |
| 語文別: | 中文 |
| 論文頁數: | 71 |
| 中文關鍵詞: | 運動素 、分子馬達 |
| 外文關鍵詞: | molecular motor, kinesin |
| 相關次數: | 點閱:115 下載:2 |
| 分享至: |
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運動素(kinesin)為一種水溶性的酵素蛋白質分子,位於細胞內,依附於微管(microtubule)做單方向的前進。運動素的頭部與核酸鍵結的方式,將主導其運動機制。
本文用擴散方程式結合馬可夫鏈推移矩陣,建立一個數學量化的模型,分別以v、L、r及 Ds這四個重要參數分析運動素處於負載下,沿著微管運動的機制,並與實驗數據做比較。
由本文研究結果顯示,運動素在不同ATP濃度下,處於低負載時,速度無明顯變化。但處於低濃度時,r值會得到比較高的值,代表此時的ATP水解,是無法與運動素做鍵結,導致化學能量無法轉換成機械能。
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