N-nitrosamines是近年來被發現之含氮消毒副產物(nitrogenous disinfection byproducts, N-DBPs)，尤其是N-nitrosodimethylamine (NDMA)，因具有致癌性這幾年被廣泛受到重視。本研究利用固相微萃取法(SPME)，配合GC/MS/MS儀器分析，減少分析所需的時間、分析體積和分析較低濃度。且可以同步分析NDMA、NMor、NDBA、NDPA、NPIP、NMEA和NDEA等7種N-nitrosamines。將此分析方法用於16座台灣自來水廠監測，結果顯示，在各水廠流程與清水中，N-nitrosamines濃度絕大數低於偵測極限。
研究中並以台灣水庫中常見之藍綠菌，包括微囊藻和柱孢藻為對象做研究，探討其與常見氧化劑反應生成NDMA之潛勢。結果顯示，微囊藻與消毒劑如次氯酸和一氯胺反應可生成NDMA，其生成量隨反應時間、一氯胺濃度及藻數增加而增加。在柱孢藻方面，使用次氯酸氧化並無明顯之NDMA生成，但與一氯胺反應，則明顯有NDMA之產生，NDMA濃度隨著一氯胺濃度及反應天數增加而升高。

N-nitrosamines are a group of emerging disinfection byproducts (DBPs) discovered in recent years. Due to their toxicity, they are regulated by a few countries and organizations in drinking water standards. In this study, solid phase micro-extraction (SPME) coupled with gas chromatograph-tadem mass spectrometer detector was deceloped for the analysis of seven N-nitrosamines, including- NDMA, NMor, NDBA, NDPA, NPIP, NMEA and NDEA. This method was further employed in monitoring the processessed water and finished water in 16 water works in Taiwan. In most of the samples, the N-nitrosamines monitored were all below detection limits, except THWTP in Kinmen Island. NDMA in the finished water of THWTP is about 23.0 ng/L, possibly due to its high organic concentrations in the raw water. The water from Tai-Hu Reservoir and from the effluent of An-Pin Wastewater Treatment Plant was found to have high NDMA formation potential. After reacting with monochloroamine, NDMA concentrations were in the range of 70-100 ng/L.
NDMA formation potentials of Microcystis aeruginosa and Cylindrospermopsis circinalis were also tested. After reacting with hypochlorite and monochloroamine, the water with Microcystis cells was found to form NDMA. The concentration increased with increasing reaction time, monochlroramine concentration concentration, and cell numbers. No NDMA was found for the reaction between hypochlorite with C. circinalis. However, after reacting with monochloroamine, NDMA was present in the water with C. circinalis. NDMA concentration was found to increase with increasing monochloamine concentration and reaction time.

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