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| 研究生： |
吳漢鐘 Wu, Han-Chung |
|---|---|
| 論文名稱： |
超臨界二氧化碳製備微奈米阿司匹靈膠囊粒子及控制釋放之模擬胃液研究 The Preparation and Controlled Release Behavior of Sub-micro Aspirin/Ethyl Cellulose Particles Produced by Supercritical Carbondioxide |
| 指導教授： |
黃宏欣
Huang, Hung-Shin 黃平志 Huang, Ping-Chih 許清雲 Hsu, Ching-Yun 黃守仁 Huang, Shou-Jen 葉茂榮 Yeh, Mao-Jung 桂椿雄 Kuei, Chuan-Hsiung |
| 學位類別： |
碩士 Master |
| 系所名稱： |
理學院 - 化學系 Department of Chemistry |
| 論文出版年： | 2003 |
| 畢業學年度： | 91 |
| 語文別： | 中文 |
| 論文頁數： | 90 |
| 中文關鍵詞： | 超臨界流體 、藥物控制釋放 、微奈米粒子 、超臨界流體增大/分散溶液 、微膠囊粒子 、多孔性微粒子 |
| 外文關鍵詞： | supercritical fluids, microspheres, microcapsules, solution enhanced/dispersion by supercritical fl, controlled-release, micro to nano particle |
| 相關次數： | 點閱：123 下載：1 |
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藥物與人類是密不可分的，不論是醫藥、農藥等產品，都與日常生活息息相關，有些藥物若投藥過量會產生副作用或造成農作及環境的傷害，而藥量太少則失去藥效，因此藥物控制釋放遂成為藥物應用重要的一環；本實驗以超臨界二氧化碳為工具藉以製備藥物控制釋放粒子，一方面減少有機溶劑的使用，一方面則可藉其絕佳的滲透性來去除藥劑中殘留的有機溶劑而避免投藥所造成的傷害。
超臨界流體製造微奈米級粒子技術常被應用在兩個方面：一為製造高表面積比的微粒子，此類粒子多應用在反應的催化；另一為雙物質系統，利用超臨界流體所製備出的多孔性微粒子(microspheres)吸附揮發性物質，或以基質包覆藥物形成微膠囊(microcapsules)，以達到控制釋放之效果。
由超臨界製程所製備出的催化劑粒子，具有相當大的孔洞體積，因而增大其表面積以增強催化效果，並能減少用量，降低成本。所製得之多孔性高分子可使藥物均勻分佈在內而緩解釋出。此外，超臨界流體可經由特殊的設計來製造微膠囊；如超臨界流體增大／分散溶液－Solution Enhanced Dispersion by Supercritical fluids (SEDS)所製造出來的微膠囊粒子可應用在藥物遞送元件中，並提供多方面的研究。
本論文主要分為兩部份探討：一為SEDS製程中各變因對製得粒子尺寸的影響，其中包含膨脹槽的壓力及溫度、藥物及基質的質量比以及藥物及基質溶液的流速等；另一則為所製得之阿司匹靈／乙基纖維素粒子在模擬胃液中控制釋放的研究及其釋藥動力模式，其中包括粒子尺寸、藥物基質質量比及其流速快慢對所得粒子在模擬胃液中的釋藥行為及釋藥模式的影響並做一系列的探討。
Medicines are important for human beings. Both medical and chemical products are related as closely as each breath to the daily live. Some drugs would induce side effect or damage the crops and environment by overdosing or cumulating, but lose its effect by not enough dosing. To overcome the situation, controlled-release of drugs becomes an important issue. This study is to producing controlled-release drug by supercritical carbondioxide process which has the benefit of decreasing the consuming of organic solvent.
The techniques of making sub-micro particles by supercritical fluid process are applicated in two territories: one is to make micro particles with high surfacing area to catalyze reactions; the other is composite system for microspheres or microcapsules; the former can absorb vaporous compounds, the latter are medicine-encapsulate by polymeric matrixes. Both of them have controlled release behavior.
Catalytic particles made by supercritical fluids have quite large pore volume to induce its catalytic power, reduce the necessary amounts of catalysis and lower the costs. Drug releasing for microspheres could also be controlled. Besides, microcapsules can be made by supercritical fluid techniques such as solution enhanced/dispersion by supercritical fluids (SEDS).
This thesis contains two parts: one is the studying on each factor in SEDS that could influences on particle size such as the pressure and the temperature of expansion vessel, the ratio of drug/matrix and the flow rate of drug and matrix solution. The other is the controlled-release behaviors of aspirin/ethyl cellulose sub-micro particles in synthetic gastric juice. The factors which affect the conditions and the mode of drug releasing include the particle size, drug/matrix ratio and the flow rate of solutions would be discussed.
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校內：立即公開校外：2003-08-22公開