本研究提出了一種穿透式測量葡萄糖光學性質之方式。大部分糖尿病患者需要長時間測量血糖濃度，而長期使用侵入式的方式不但飽受痛苦還容易造成感染或過度破壞皮膚組織，研發一套非侵入式血糖量測系統能是病患降低測量時的痛苦、並輕鬆的監測病情。利用光旋性物質溶於水時改變了溶液的折射率使其濃度與光學參數上存在著物理性質。
在本研究中將藉由史托克-穆勒偏光儀校正系統並由光學感測器接收光強，並解出圓性雙折射(CB) 及去偏極化 (Dep)之穆勒矩陣。此系統是將每種不同樣本以對應最少的入射光來取得其光學參數來計算濃度。本實驗經由電光調變器(Electro-optic modulators)來取代原本的光學元件，能有效減少調整時所造成的誤差，並藉由光學斬光器和鎖相放大器來減少光源不穩定的誤差，達到振幅調變的效果。在葡萄糖的測量上，商業的史托克儀就能達到100mg/dl的靈敏度，此系統更讓靈敏度達到40mg/dl。並由此系統量測圓二色性 (CD) 及去偏極化 (Dep) 之穆勒矩陣，而使用擁有圓二色性的葉綠素來測試，也能發現此系統對在有色溶液中的靈敏度高於無色的溶液。

A new transmitted optical system of the glucose measurement based upon polarization scanning ellipsometry with amplitude modulation is proposed. Most diabetic patients always need to measure blood glucose concentration. However, long-term measurement by using of invasive monitoring not only suffer pain but also cause infection or excessive destruction of skin tissue. Developing a non-invasive blood glucose measurement system can reduce pain and monitor the disease easily by a physical correlation that may exist between the optical coefficient and concentration of optical activity substance.
In this study, calculating the Mueller matrix of the circular birefringence (CB) plus depolarization (Dep) and circular dichroism (CD) plus depolarization (Dep) by the intensity of photodetector is developed. We calculate the optical parameters by transmitting a minimum amount of incident light for the different concentration of sample in the system. Amplitude modulation is able to effectively increase the stability and sensitivity of the extracted intensity by the optical chopper in the polarization scanning ellipsometry. Thus, the total Mueller matrix of a sample can be extracted correctly and as a result, the parameters in CB, CD, and Dep are successfully obtained.

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