由於生物組織對於近紅外光區段有最小的吸收係數與相對較大的穿透度。在適合的雷射波長與強度照射下，可對生物組織達到最小的傷害，達到更好的分析深度。因此，可將此概念應用於藥物載體與釋放之動力學上。為改善傳統藥物載體在運送過程藥物逐漸釋放的缺點，本研究以雙股去氧核醣核酸(Deoxyribonucleic acid，DNA)作為藥物載體的開關，希望透過光驅動藥物控制釋放(light triggered control drug release)之機制，使雙股DNA去雜交並釋放抗癌藥物doxorubicin;與過去研究不同的是：在藥物控制釋放系統中，以往藥物載體開關打開後，無其他應用功能；本研究，以小片段干擾雙股核糖核酸(small interfering Ribonucleic acid，siRNA)作為開關，以增加開關被打開時的功能性，藉此展示以基因治療工程並結合藥物釋放以達到最佳治療效用。
本篇論文研究，以近紅外光可調式之金奈米棒，包覆上具有高承載量及生物相容性高的多孔洞二氧化矽殼層作為藥物載體，並裝填抗癌藥物(doxorubicin)。藉雙股DNA為開關，在近紅外光的照射下，金奈米棒將光能轉換成熱能，該熱能會繼續轉移至表面的雙股DNA，使雙股DNA受熱去雜交，並使藥物釋放出來，進而殺死癌細胞。另外，延伸以GFP-22之siRNA作為開關，以展示siRNA去雜交後進入細胞核內，並達到基因治療的功用。本研究結合藥物控制釋放以及基因工程治療，在此雙重治療下，達成更有效率地治療效果。使得多孔洞二氧化矽金奈米棒結合搭載不同功能的siRNA，在生物醫學應用上具有發展的潛力。

The near-infrared (NIR) region, where tissue transmission is optimal due to low scattering and energy absorption, provides maximum irradiation penetration through tissue and often utilizes NIR window applied in biology, such as drug release. To improve the defect of conventional carriers gradually released the interior drug in the duration of drug release, using double-stranded DNA as the caps of drug carrier made the DNA proceed dehybridization to release the interior anti-cancer drug doxorubicin via light triggered control drug release. In the drug control & release dynamic system, this work was different from the conventional carriers that have no other applied functions after switch-on the caps. Besides, the other cap, siRNA, was also utilized in this work to display the optimal therapeutic effectiveness by the combination of gene therapy and drug release to apparently elevate its functionality as switching-on.
In this study, of gold nanorods by tuning their aspect ratio, adsorb on the mesoporous silica shell of high capacity and excellent biocompatibility to load the doxorubicin. Gold nanorods are capable of high efficiently to convert absorbed radiation into heat in the exposure of NIR. The heat would transfer to the double-stranded DNA coated on the surface of nanomaterials to make it dehybridized, and sequentially control the dynamics of drug release to easily eliminate cancer cells. Furthermore, the other extension of this research was to use GFP-22 siRNA as the cap and demonstrated the dehybridized siRNA would be transferred into the nucleus to prove the function of the nanomaterials in gene therapy. This novel platform is to serve as not only a chemotherapeutic agent but also a gene therapeutic agent to efficiently and synergistically kill malignant cells. These results might suggest that this novel material is capable of the potential in bio-medical applications.

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