憂鬱症為全球主要的精神疾病之一，常伴隨注意力、記憶力與執行功能等認知障礙，進一步影響情緒調節與日常生活品質。近年來，數位心理健康介入逐漸興起，遊戲化訓練成為一種具潛力的非藥物介入方式。本研究開發一款結合五種記憶訓練遊戲與衛教內容的應用程式，並進行初步人體研究，以探討此系統對憂鬱症患者在情緒調節上的可行性與潛在成效。
本研究納入精神科醫師診斷為憂鬱症之受試者四位，進行為期一個月的遊戲訓練，訓練前後皆填寫11份心理相關問卷。遊戲訓練完成時間的分析，部分受試者在完成時間、開始延遲時間、反應時間呈現顯著進步，也有部分受試者在壓力知覺、情緒調節能力與心理韌性量表上有改善。系統可用性量表平均分數為81.25，顯示使用者對系統易用性與接受度皆具高度肯定。
本研究所開發遊戲化數位介入系統在改善憂鬱症患者調節情緒有可行性與初步人體研究成效，未來可進一步擴大樣本數、延長訓練週期並結合更多元的評估方式，以驗證其長期效益與臨床應用潛力。

Depression is one of the most prevalent mental health disorders worldwide, often accompanied by cognitive impairments such as attention deficits, poor memory, and diminished executive function. These impairments can hinder emotion regulation and reduce overall quality of life. In recent years, digital interventions have gained attention as non-pharmacological alternatives, with gamified cognitive training showing promise in improving mental health outcomes.
This study presents the development and preliminary evaluation of an Android-based e-mental health application designed for individuals with Major Depressive Disorder (MDD). The app integrates five types of memory games and psychoeducational content. A pilot human research study was conducted with four participants diagnosed with MDD by psychiatrists. Each participant underwent a one-month intervention. Pre- and post-assessment data were collected using psychological scales and in-game performance metrics.
Results showed that some participants demonstrated significant improvement in specific performance metrics, including completion time, start time offset, and reaction time. Some participants also showed reduced perceived stress and enhanced resilience and emotional regulation. The average System Usability Scale (SUS) score was 81.25, indicating high usability and user satisfaction.
These findings support the feasibility and preliminary efficacy of a gamified cognitive intervention for depression. Future studies with larger sample sizes, longer intervention durations, and objective assessments are warranted to further validate its clinical potential.

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