本研究乃是設計及合成可包接膽紅素之功能性有機金屬網狀架構 (metallo-organic framework, MOF)。該材料為一種有機無機混成材料，為有規律之立體結構、對稱性結構以及孔洞性結構，同時，網狀架構具有撓性，供給賓分子進出材料之彈性立體結構中。以不同前驅物合成之有機金屬網狀架構可具有不同之特性，在文獻中亦有不同之應用已發表。
於本研究中前驅物為卟吩 (porphine) 之衍生物，5,10,15,20-tetra(4-pyridyl)-21H,23H- porphine (TPyP)，利用二價鋅進行與前驅物之合成研究探討。合成有機金屬網狀結構之鍵結作用力可來自分子間氫鍵及 TPyP 結構中之卟啉、吡啶官能基之平面 pi-pi 作用力及其金屬之 d 軌域提供之配位建結。TPyP 之立體對稱性為合成有機金屬網狀結構不可或缺的要素，除了提供規則重複排列之結晶結構生成，更提升結晶排列上多樣之可能性。將合成之有機金屬網狀結構 (Zn(II)-TPyP) 進行各項儀器分析，以傅立葉轉換紅外光光譜儀 (Fourier transform infrared spectrometer, FT-IR)、可見光/紫外光光譜儀 (UV/Vis spectrophotometer) 以及歐傑電子能譜儀 (Auger electron spectroscopy, AES) 鑑定分析，確定鋅金屬化合物與 TPyP 形成 Zn(II)-TPyP；由掃描式電子顯微鏡 (scanning electron microscope, SEM)、X-ray 繞射儀 (X-ray powder diffractometer, XRD) 以及小角度 X 光散射儀 (small angle X-ray scattering, SAXS) 觀察其微結構及結晶性，顯現出 Zn(II)-TPyP 成功形成規則之六角形柱狀結構；以熱重分析儀 (thermogravimetry analyzer, TGA) 得到該結構於 250 oC，釋放大量結晶水及溶劑賓分子，而其結構熱穩定約可達600 oC；在吸附實驗中 BET (Brunauer-Emmett-Teller) 分析得到 Zn(II)-TPyP 網狀結構之 BET surface area 大約為 8.41 m2/g，Langmuir surface area大約為 12.57 m2/g，孔洞體積約為 0.036 cm3/g；另外，以螢光光譜儀及電化學分析儀進行測定，該材料皆表現出良好的螢光性質以及導電性。
在 ZnTPyP 對膽紅素之吸附實驗中，結果指出本研究合成之有機金屬網狀結構化合物確實具有對膽紅素吸附之能力，並顯示未來在臨床應用之可行性及潛力。

In this work, 5,10,15,20-tetra(4-pyridyl)-21H,23H-porphine (TPyP), a compound of porphine series is used as the precursor for the synthesis of hybrid organic-inorganic polymeric materials. It is via the interactions between the organic precursors as well as the coordination of the metal ions with the precursors to achieve a supramolecular conformation both with rigidity and flexibility. It owns geometric regularity from its repeated and symmetric structure (and chains) while, on the other hand, it also owns the property of softness for the inclusion of guest molecules into its flexible framework. Thus, a kind of soft materials with large molecular weights is created. The formation of the metallo-organic framework could be the consequence of the hydrogen bonds, the pi-pi interaction of the porphine-based plane and the coordination bond from d-orbit of the metal compound. The geometric symmetry of the TPyP precursor is an essential feature contributing to the assembly and therefore the formation of the metallic organic crystal. The metal-TPyP as prepared is measured by an FTIR and a UV/Vis spectrophotometer to analyze the bonding between the metal compound and the TPyP precursor. An SEM, an XRD, and an SAXS are altogether used to discover the micro-structure and also the crystallinity of the Zn(II)-TPyP. Thermo-stability is measured by a TGA. It could be concluded from the result that the framework could remain stable until approximately 600 oC. The synthesized Zn(II)-TPyP in this work is further analyzed by a BET. The BET surface area of 8.41 m2/g, the Langmuir surface area of 12.57 m2/g, and the pore volume of 0.036 cm3/g are all obtained. Additionally, Zn(II)-TPyP is confirmed that it indeed shows good performance in both fluorescence property and electro-conductivity.
Different metal ions are also chosen to be coordinated with the TPyP precursor. Among these MOFs (metal-organic frameworks) being synthesized, ZnTPyP is chosen for the absorption investigation on the bilirubin molecules. Consequently, the results already confirm the inclusion ability of the metal-organic polymers towards bilirubin

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