二維結構的硫化鉬在近紅外光具有吸收特性，其生物醫學的應用在近年來蓬勃發展，然而受限於材料本身的物理性質與製備方法，合成具幾何結構的形狀外貌有其難度，尚未報導高均勻性的零維硫化鉬材料導入癌症治療之領域。因此，本篇發展氧化矽/硫化鉬混合結構的中空奈米球殼作為治療試劑，起初以多孔性氧化矽奈米球體為模板，添加鉬的前驅物以及硫脲在酸性條件下水熱反應，並執行退火與鹼蝕的程序，此技術能進一步控制中空奈米球殼的顆粒尺寸與球殼厚度。此外，本篇首先證實硫化鉬相關材料具有超聲波顯影的潛力，且顯影效果受到合成球殼之厚薄大小的形貌影響，能使載體具備有效治療與診斷功能的卓越表現。

Two dimensional MoS2 with graphene-like layered structure have been already reported its promising potential for biomedical applications of theranostic agents. However, MoS2 nanosheets have suffered from the wide distribution of their size due to the manner of preparation resulting in the presence of the inevitable irregular shape. Until now, it have been plagued with no further controllable shapes of MoS2 morphology that was explored for biomedical applications except layered structure. We develop a zero dimensional hollow silica/MoS2 hybrid nanoshells (h-SiO2/MoS2) as theranostic agents. Starting with SiO2 nanosphere as a template through a hydrothermal reaction of Na2MoO4 and thiourea in the acidic environment formed MoS3 on the surface of SiO2. Subsequently, the pyrolysis transformed to MoS2 followed by an etching procedure for using PBS (pH = 10) to generate a hollow structure. The h-SiO2/MoS2 also acts as echogenic source to give ultrasound imaging that is not seen using layered structure. What’s more, it is a successful course of experiment that can control the particle size and shell thickness of h-SiO2/MoS2, which presents the effective photothermal therapy and the diverse echogenic effect.

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