| 研究生: |
林元元 Lin, Yuan-Yuan |
|---|---|
| 論文名稱: |
早年時期抗生素暴露對小鼠行為及腸道細菌之影響 The impact of early-life antibiotics exposure on the behaviors and gut microbiota in mice |
| 指導教授: |
吳偉立
Wu, Wei-Li |
| 學位類別: |
碩士 Master |
| 系所名稱: |
醫學院 - 生理學研究所 Department of Physiology |
| 論文出版年: | 2021 |
| 畢業學年度: | 109 |
| 語文別: | 英文 |
| 論文頁數: | 72 |
| 中文關鍵詞: | 自閉症類群障礙 、早產兒 、早年時期階段 、抗生素暴露 、社交行為 、類焦慮行為 、類憂鬱行為 、腸道微生物相 、腸道運動 、睡眠剝奪 |
| 外文關鍵詞: | Autism spectrum disorder (ASD), Preterm infants, Early-life stage, Antibiotic exposure, Social behavior, Anxiety-like behavior, Depressive-like behavior, Gut microbiota, Gut motility, Sleep deprivation |
| 相關次數: | 點閱:277 下載:0 |
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Aarnoudse-Moens CS, Weisglas-Kuperus N, van Goudoever JB, Oosterlaan J (2009) Meta-analysis of neurobehavioral outcomes in very preterm and/or very low birth weight children. Pediatrics 124:717-728.
Al Nabhani Z, Dulauroy S, Marques R, Cousu C, Al Bounny S, Déjardin F, Sparwasser T, Bérard M, Cerf-Bensussan N, Eberl G (2019) A Weaning Reaction to Microbiota Is Required for Resistance to Immunopathologies in the Adult. Immunity 50:1276-1288.e1275.
Alcon-Giner C, Dalby MJ, Caim S, Ketskemety J, Shaw A, Sim K, Lawson MAE, Kiu R, Leclaire C, Chalklen L, Kujawska M, Mitra S, Fardus-Reid F, Belteki G, McColl K, Swann JR, Kroll JS, Clarke P, Hall LJ (2020) Microbiota Supplementation with Bifidobacterium and Lactobacillus Modifies the Preterm Infant Gut Microbiota and Metabolome: An Observational Study. Cell Report Medicine 1:100077.
Bauman MD, Iosif AM, Smith SE, Bregere C, Amaral DG, Patterson PH (2014) Activation of the maternal immune system during pregnancy alters behavioral development of rhesus monkey offspring. Biological Psychiatry 75:332-341.
Ben Simon E, Walker MP (2018) Sleep loss causes social withdrawal and loneliness. Nature Communications 9:3146.
Bick J, Nelson CA (2016) Early Adverse Experiences and the Developing Brain. Neuropsychopharmacology 41:177-196.
Bäckhed F, Roswall J, Peng Y, Feng Q, Jia H, Kovatcheva-Datchary P, Li Y, Xia Y, Xie H, Zhong H, Khan MT, Zhang J, Li J, Xiao L, Al-Aama J, Zhang D, Lee YS, Kotowska D, Colding C, Tremaroli V, Yin Y, Bergman S, Xu X, Madsen L, Kristiansen K, Dahlgren J, Wang J (2015) Dynamics and Stabilization of the Human Gut Microbiome during the First Year of Life. Cell Host Microbe 17:690-703.
Bojović K, Ignjatović Ð I, Soković Bajić S, Vojnović Milutinović D, Tomić M, Golić N, Tolinački M (2020) Gut Microbiota Dysbiosis Associated With Altered Production of Short Chain Fatty Acids in Children With Neurodevelopmental Disorders. Frontiers in Cellular and Infection Microbiology 10:223.
Bryant PA, Trinder J, Curtis N (2004) Sick and tired: does sleep have a vital role in the immune system? Nature Reviews Immunology 4:457-467.
Buffington SA, Di Prisco GV, Auchtung TA, Ajami NJ, Petrosino JF, Costa-Mattioli M (2016) Microbial Reconstitution Reverses Maternal Diet-Induced Social and Synaptic Deficits in Offspring. Cell 165:1762-1775.
Buffington SA, Dooling SW, Sgritta M, Noecker C, Murillo OD, Felice DF, Turnbaugh PJ, Costa-Mattioli M (2021) Dissecting the contribution of host genetics and the microbiome in complex behaviors. Cell 184:1740-1756.e1716.
Chen L-W, Wang S-T, Wang L-W, Kao Y-C, Chu C-L, Wu C-C, Hsieh Y-T, Chiang C-H, Huang C-C (2019) Behavioral characteristics of autism spectrum disorder in very preterm birth children. Molecular Autism 10:32.
Choi GB, Yim YS, Wong H, Kim S, Kim H, Kim SV, Hoeffer CA, Littman DR, Huh JR (2016) The maternal interleukin-17a pathway in mice promotes autism-like phenotypes in offspring. Science 351:933-939.
Connolly N, Anixt J, Manning P, Ping ILD, Marsolo KA, Bowers K (2016) Maternal metabolic risk factors for autism spectrum disorder-An analysis of electronic medical records and linked birth data. Autism Research 9:829-837.
Cryan JF, Holmes A (2005) The ascent of mouse: advances in modelling human depression and anxiety. Nature Reviews Drug Discovery 4:775-790.
Cryan JF, Dinan TG (2012) Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour. Nature Reviews Neuroscience 13:701-712.
Dashti HS, Scheer FA, Jacques PF, Lamon-Fava S, Ordovás JM (2015) Short sleep duration and dietary intake: epidemiologic evidence, mechanisms, and health implications. Advances in Nutrition 6:648-659.
De Palma G, Blennerhassett P, Lu J, Deng Y, Park AJ, Green W, Denou E, Silva MA, Santacruz A, Sanz Y, Surette MG, Verdu EF, Collins SM, Bercik P (2015) Microbiota and host determinants of behavioural phenotype in maternally separated mice. Nature communications 6:7735.
Derrien M, Alvarez AS, de Vos WM (2019) The Gut Microbiota in the First Decade of Life. Trends in Microbiology 27:997-1010.
Dey N, Wagner VE, Blanton LV, Cheng J, Fontana L, Haque R, Ahmed T, Gordon JI (2015) Regulators of gut motility revealed by a gnotobiotic model of diet-microbiome interactions related to travel. Cell 163:95-107.
Dinan TG, Cryan JF (2017) Brain–gut–microbiota axis — mood, metabolism and behaviour. Nature Reviews Gastroenterology & Hepatology 14:69-70.
Durack J, Kimes NE, Lin DL, Rauch M, McKean M, McCauley K, Panzer AR, Mar JS, Cabana MD, Lynch SV (2018) Delayed gut microbiota development in high-risk for asthma infants is temporarily modifiable by Lactobacillus supplementation. Nature Communications 9:707.
Dutil C, Chaput JP (2017) Inadequate sleep as a contributor to type 2 diabetes in children and adolescents. Nutrition & Diabetes 7:e266-e266.
Elsabbagh M, Divan G, Koh YJ, Kim YS, Kauchali S, Marcín C, Montiel-Nava C, Patel V, Paula CS, Wang C, Yasamy MT, Fombonne E (2012) Global prevalence of autism and other pervasive developmental disorders. Autism Research 5:160-179.
Endo N, Makinodan M, Mannari-Sasagawa T, Horii-Hayashi N, Somayama N, Komori T, Kishimoto T, Nishi M (2021) The effects of maternal separation on behaviours under social-housing environments in adult male C57BL/6 mice. Scientific Reports 11:527.
Estes ML, McAllister AK (2016) Maternal immune activation: Implications for neuropsychiatric disorders. Science 353:772-777.
Ferretti P, Pasolli E, Tett A, Asnicar F, Gorfer V, Fedi S, Armanini F, Truong DT, Manara S, Zolfo M, Beghini F, Bertorelli R, De Sanctis V, Bariletti I, Canto R, Clementi R, Cologna M, Crifò T, Cusumano G, Gottardi S, Innamorati C, Masè C, Postai D, Savoi D, Duranti S, Lugli GA, Mancabelli L, Turroni F, Ferrario C, Milani C, Mangifesta M, Anzalone R, Viappiani A, Yassour M, Vlamakis H, Xavier R, Collado CM, Koren O, Tateo S, Soffiati M, Pedrotti A, Ventura M, Huttenhower C, Bork P, Segata N (2018) Mother-to-Infant Microbial Transmission from Different Body Sites Shapes the Developing Infant Gut Microbiome. Cell Host & Microbe 24:133-145.e135.
Fuglsang E, Pizzolla A, Krych L, Nielsen DS, Brooks AG, Frøkiær H, Reading PC (2018) Changes in Gut Microbiota Prior to Influenza A Virus Infection Do Not Affect Immune Responses in Pups or Juvenile Mice. Frontiers in Cellular and Infection Microbiology 8:319.
Fung TC, Olson CA, Hsiao EY (2017) Interactions between the microbiota, immune and nervous systems in health and disease. Nature Neuroscience 20:145-155.
Gaspar RS, Unsworth AJ, Al-Dibouni A, Bye AP, Sage T, Stewart M, Wells S, Cox RD, Gibbins JM, Sellayah D, E. Hughes C (2021) Maternal and offspring high-fat diet leads to platelet hyperactivation in male mice offspring. Scientific Reports 11:1473.
Gasparrini AJ, Wang B, Sun X, Kennedy EA, Hernandez-Leyva A, Ndao IM, Tarr PI, Warner BB, Dantas G (2019) Persistent metagenomic signatures of early-life hospitalization and antibiotic treatment in the infant gut microbiota and resistome. Nature Microbiology 4:2285-2297.
Giovanoli S, Engler H, Engler A, Richetto J, Voget M, Willi R, Winter C, Riva MA, Mortensen PB, Feldon J, Schedlowski M, Meyer U (2013) Stress in puberty unmasks latent neuropathological consequences of prenatal immune activation in mice. Science 339:1095-1099.
Godfrey KM, Reynolds RM, Prescott SL, Nyirenda M, Jaddoe VW, Eriksson JG, Broekman BF (2017) Influence of maternal obesity on the long-term health of offspring. The Lancet Diabetes & Endocrinology 5:53-64.
Godinho-Silva C, Domingues RG, Rendas M, Raposo B, Ribeiro H, da Silva JA, Vieira A, Costa RM, Barbosa-Morais NL, Carvalho T, Veiga-Fernandes H (2019) Light-entrained and brain-tuned circadian circuits regulate ILC3s and gut homeostasis. Nature 574:254-258.
Greer SM, Goldstein AN, Walker MP (2013) The impact of sleep deprivation on food desire in the human brain. Nature Communications 4:2259.
Grzadzinski R, Huerta M, Lord C (2013) DSM-5 and autism spectrum disorders (ASDs): an opportunity for identifying ASD subtypes. Molecular Autism 4:12.
Hastings MH, Maywood ES, Brancaccio M (2018) Generation of circadian rhythms in the suprachiasmatic nucleus. Nature Reviews Neuroscience 19:453-469.
Holding BC, Sundelin T, Lekander M, Axelsson J (2019) Sleep deprivation and its effects on communication during individual and collaborative tasks. Scientific Reports 9:3131.
Hsiao EY, McBride SW, Hsien S, Sharon G, Hyde ER, McCue T, Codelli JA, Chow J, Reisman SE, Petrosino JF, Patterson PH, Mazmanian SK (2013) Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders. Cell 155:1451-1463.
James FO, Cermakian N, Boivin DB (2007) Circadian rhythms of melatonin, cortisol, and clock gene expression during simulated night shift work. Sleep 30:1427-1436.
Jones JR, Simon T, Lones L, Herzog ED (2018) Circadian clock neurons mediate time-of-day dependent responses to light. bioRxiv:291955.
Kamdar S, Hutchinson R, Laing A, Stacey F, Ansbro K, Millar MR, Costeloe K, Wade WG, Fleming P, Gibbons DL (2020) Perinatal inflammation influences but does not arrest rapid immune development in preterm babies. Nature Communications 11:1284.
Khalak R, Cummings J, Dexter S (2015) Maternal obesity: significance on the preterm neonate. International Journal of Obesity 39:1433-1436.
Kim S, Kim H, Yim YS, Ha S, Atarashi K, Tan TG, Longman RS, Honda K, Littman DR, Choi GB, Huh JR (2017) Maternal gut bacteria promote neurodevelopmental abnormalities in mouse offspring. Nature 549:528-532.
Knuesel I, Chicha L, Britschgi M, Schobel SA, Bodmer M, Hellings JA, Toovey S, Prinssen EP (2014) Maternal immune activation and abnormal brain development across CNS disorders. Nature Reviews Neurology 10:643-660.
Kobayashi H, Oethinger M, Tuohy MJ, Hall GS, Bauer TW (2010) Distinction between intact and antibiotic-inactivated bacteria by real-time PCR after treatment with propidium monoazide. Journal of Orthopaedic Research 28:1245-1251.
Korpela K, Blakstad EW, Moltu SJ, Strømmen K, Nakstad B, Rønnestad AE, Brække K, Iversen PO, Drevon CA, de Vos W (2018) Intestinal microbiota development and gestational age in preterm neonates. Scientific Reports 8:2453.
Leclercq S, Mian FM, Stanisz AM, Bindels LB, Cambier E, Ben-Amram H, Koren O, Forsythe P, Bienenstock J (2017) Low-dose penicillin in early life induces long-term changes in murine gut microbiota, brain cytokines and behavior. Nature communications 8:15062.
Li S, Ning K, Zhou J, Guo Y, Zhang H, Zhu Y, Zhang L, Jia C, Chen Y, Sol Reinach P, Liu Z, Li W (2018) Sleep deprivation disrupts the lacrimal system and induces dry eye disease. Experimental & Molecular Medicine 50:e451.
Liu GX, Cai GQ, Cai YQ, Sheng ZJ, Jiang J, Mei Z, Wang ZG, Guo L, Fei J (2007) Reduced anxiety and depression-like behaviors in mice lacking GABA transporter subtype 1. Neuropsychopharmacology 32:1531-1539.
Lun MP, Monuki ES, Lehtinen MK (2015) Development and functions of the choroid plexus–cerebrospinal fluid system. Nature Reviews Neuroscience 16:445-457.
Machado CJ, Whitaker AM, Smith SE, Patterson PH, Bauman MD (2015) Maternal immune activation in nonhuman primates alters social attention in juvenile offspring. Biological Psychiatry 77:823-832.
Maenner MJ, Rice CE, Arneson CL, Cunniff C, Schieve LA, Carpenter LA, Van Naarden Braun K, Kirby RS, Bakian AV, Durkin MS (2014) Potential Impact of DSM-5 Criteria on Autism Spectrum Disorder Prevalence Estimates. JAMA Psychiatry 71:292-300.
Maenner MJ, Shaw KA, Baio J, Washington A, Patrick M, DiRienzo M, Christensen DL, Wiggins LD, Pettygrove S, Andrews JG, Lopez M, Hudson A, Baroud T, Schwenk Y, White T, Rosenberg CR, Lee LC, Harrington RA, Huston M, Hewitt A, Esler A, Hall-Lande J, Poynter JN, Hallas-Muchow L, Constantino JN, Fitzgerald RT, Zahorodny W, Shenouda J, Daniels JL, Warren Z, Vehorn A, Salinas A, Durkin MS, Dietz PM (2020) Prevalence of Autism Spectrum Disorder Among Children Aged 8 Years - Autism and Developmental Disabilities Monitoring Network, 11 Sites, United States, 2016. Morbidity and Mortality Weekly Report 69:1-12.
Malkova NV, Yu CZ, Hsiao EY, Moore MJ, Patterson PH (2012) Maternal immune activation yields offspring displaying mouse versions of the three core symptoms of autism. Brain, Behavior, and Immunity 26:607-616.
Marin IA, Goertz JE, Ren T, Rich SS, Onengut-Gumuscu S, Farber E, Wu M, Overall CC, Kipnis J, Gaultier A (2017) Microbiota alteration is associated with the development of stress-induced despair behavior. Scientific Reports 7:43859.
Modabbernia A, Velthorst E, Reichenberg A (2017) Environmental risk factors for autism: an evidence-based review of systematic reviews and meta-analyses. Molecular Autism 8:13.
Ozonoff S, Heung K, Byrd R, Hansen R, Hertz-Picciotto I (2008) The onset of autism: patterns of symptom emergence in the first years of life. Autism Research 1:320-328.
Palkova L, Tomova A, Repiska G, Babinska K, Bokor B, Mikula I, Minarik G, Ostatnikova D, Soltys K (2021) Evaluation of 16S rRNA primer sets for characterisation of microbiota in paediatric patients with autism spectrum disorder. Scientific Reports 11:6781.
Patti CL, Zanin KA, Sanday L, Kameda SR, Fernandes-Santos L, Fernandes HA, Andersen ML, Tufik S, Frussa-Filho R (2010) Effects of sleep deprivation on memory in mice: role of state-dependent learning. Sleep 33:1669-1679.
Peng C, Ouyang Y, Lu N, Li N (2020) The NF-κB Signaling Pathway, the Microbiota, and Gastrointestinal Tumorigenesis: Recent Advances. Frontiers in Immunology 11:1387.
Rahman SA, Wright KP, Lockley SW, Czeisler CA, Gronfier C (2019) Characterizing the temporal Dynamics of Melatonin and Cortisol Changes in Response to Nocturnal Light Exposure. Scientific Reports 9:19720.
Ray K (2012) Adding weight to the microbiota's role in obesity—exposure to antibiotics early in life can lead to increased adiposity. Nature Reviews Endocrinology 8:623-623.
Rein B, Ma K, Yan Z (2020) A standardized social preference protocol for measuring social deficits in mouse models of autism. Nature Protocols 15:3464-3477.
Renz H, Skevaki C (2021) Early life microbial exposures and allergy risks: opportunities for prevention. Nature Reviews Immunology 21:177-191.
Riemann D, Krone LB, Wulff K, Nissen C (2020) Sleep, insomnia, and depression. Neuropsychopharmacology 45:74-89.
Roswall J, Olsson LM, Kovatcheva-Datchary P, Nilsson S, Tremaroli V, Simon MC, Kiilerich P, Akrami R, Krämer M, Uhlén M, Gummesson A, Kristiansen K, Dahlgren J, Bäckhed F (2021) Developmental trajectory of the healthy human gut microbiota during the first 5 years of life. Cell Host & Microbe 29:765-776.e763.
Sandin S, Lichtenstein P, Kuja-Halkola R, Larsson H, Hultman CM, Reichenberg A (2014) The familial risk of autism. Journal of the American Medical Association 311:1770-1777.
Sgritta M, Dooling SW, Buffington SA, Momin EN, Francis MB, Britton RA, Costa-Mattioli M (2019) Mechanisms Underlying Microbial-Mediated Changes in Social Behavior in Mouse Models of Autism Spectrum Disorder. Neuron 101:246-259.e246.
Shih H-T, Mok H-K (2000) ETHOM: event-recording computer software for the study of animal behavior. Acta Zoologica Taiwanica.
Silverman JL, Yang M, Lord C, Crawley JN (2010) Behavioural phenotyping assays for mouse models of autism. Nature Reviews Neuroscience 11:490-502.
Stewart CJ, Ajami NJ, O’Brien JL, Hutchinson DS, Smith DP, Wong MC, Ross MC, Lloyd RE, Doddapaneni H, Metcalf GA, Muzny D, Gibbs RA, Vatanen T, Huttenhower C, Xavier RJ, Rewers M, Hagopian W, Toppari J, Ziegler A-G, She J-X, Akolkar B, Lernmark A, Hyoty H, Vehik K, Krischer JP, Petrosino JF (2018) Temporal development of the gut microbiome in early childhood from the TEDDY study. Nature 562:583-588.
Takahashi K, Nakagawasai O, Nemoto W, Odaira T, Sakuma W, Onogi H, Nishijima H, Furihata R, Nemoto Y, Iwasa H, Tan-No K, Tadano T (2019) Effect of Enterococcus faecalis 2001 on colitis and depressive-like behavior in dextran sulfate sodium-treated mice: involvement of the brain-gut axis. Journal of Neuroinflammation 16:201.
Tanaka M, Nakayama J (2017) Development of the gut microbiota in infancy and its impact on health in later life. Allergology International 66:515-522.
Thaiss CA, Zeevi D, Levy M, Zilberman-Schapira G, Suez J, Tengeler AC, Abramson L, Katz MN, Korem T, Zmora N, Kuperman Y, Biton I, Gilad S, Harmelin A, Shapiro H, Halpern Z, Segal E, Elinav E (2014) Transkingdom control of microbiota diurnal oscillations promotes metabolic homeostasis. Cell 159:514-529.
Thaiss CA, Levy M, Korem T, Dohnalová L, Shapiro H, Jaitin DA, David E, Winter DR, Gury-BenAri M, Tatirovsky E, Tuganbaev T, Federici S, Zmora N, Zeevi D, Dori-Bachash M, Pevsner-Fischer M, Kartvelishvily E, Brandis A, Harmelin A, Shibolet O, Halpern Z, Honda K, Amit I, Segal E, Elinav E (2016) Microbiota Diurnal Rhythmicity Programs Host Transcriptome Oscillations. Cell 167:1495-1510.e1412.
Videnovic A, Lazar AS, Barker RA, Overeem S (2014) 'The clocks that time us'—circadian rhythms in neurodegenerative disorders. Nature Reviews Neurology 10:683-693.
Wu WL, Adame MD, Liou CW, Barlow JT, Lai TT, G. S, Schretter CE, Needham BD, Wang MI, Tang W, Ousey J, Lin YY, Yao TH, Abdel-Haq R, Beadle K, Gradinaru V, Ismagilov RF, Mazmanian SK (2021) Microbiota regulate social behavior via stress response neurons in the brain. Nature.
Zheng D, Liwinski T, Elinav E (2020) Interaction between microbiota and immunity in health and disease. Cell Research 30:492-506.
Zhong H, Penders J, Shi Z, Ren H, Cai K, Fang C, Ding Q, Thijs C, Blaak EE, Stehouwer CDA, Xu X, Yang H, Wang J, Wang J, Jonkers DMAE, Masclee AAM, Brix S, Li J, Arts ICW, Kristiansen K (2019) Impact of early events and lifestyle on the gut microbiota and metabolic phenotypes in young school-age children. Microbiome 7:2.
Zhou Y, Cui C, Ma X, Luo W, Zheng SG, Qiu W (2020) Nuclear Factor κB (NF-κB)-Mediated Inflammation in Multiple Sclerosis. Frontiers in Immunology 11:391.
Zmora N, Suez J, Elinav E (2019) You are what you eat: diet, health and the gut microbiota. Nature Reviews Gastroenterology & Hepatology 16:35-56.