鹵胺類抗菌劑不只具備以往抗菌劑優點，廣譜的抗菌能力，還有低毒性、高穩定性及最重要的再生特性，能大幅降低一次性抗菌醫材使用的浪費，使其成為新一代的抗菌材料。此外，材料表面的不特定的生物分子貼附，推動了抗貼附材料的研發。而兩種方向都是材料在生物分子的影響下，所發展出的應用策略，故許多學者嘗試以結合兩者特性進行探討。
在本文中，設計在棉纖維上結合殺菌-鹵胺與抗細菌貼附-聚乙二醇兩項特性。首先會合成3-triethoxysilylpropyl-5,5-dimethylhydantoin (NSi)，為一矽烷系鹵胺類，對產物的結構進行鑑定。Poly(ethylene glycol) diglycidyl ether (PEGDE)的改質層則透過XPS，確認鹵胺抗菌處理下的穩定性。兩部分得到解釋後，我們採用浸軋法，以化學鍵結方式，將其結合到棉纖維上。後續利用FTIR檢測織物處理效果，並探討親疏水性的影響。而應用方面，針對細菌貼附與抗菌測試兩方向進行檢測，也討論到水洗穩定性的問題。
各實驗結果中，在基於NSi導入PEGDE的纖維，展現出較佳的親水性、數量少的細菌貼附，可歸納出親疏水性與細菌貼附量相關性。抗菌應用方面，即使是經過多次水洗，殺菌效能依然展現良好效果。綜上所述，我們以簡單的浸軋法製備樣品，先檢測織物改質層結構特性，後續透過抗菌效能及細菌貼附測試，闡述應用效能，也得到不錯效果，使得棉纖維得到了更有潛力的發展。

N-halamine antibacterial materials attracted a wide attention to researchers due to their wide antibacterial spectrum, non-toxicity, long-term stability, and most important of all, rechargeability, which can significantly reduce waste of disposable biomaterials. Meanwhile, the performance of materials has been demonstrated to be compromised by the non-specific bacterial attachment. This issue has led to the development of anti-adhesion materials. Henceforth, researchers have proposed to develop materials with characteristics integrating bactericidal and antimicrobial adhesion for antibacterial applications. In this article, we presented a facile approach to produce antimicrobial fabric, which integrates N-halamine and poly ethylene glycol coating. First, an organosilicon N-halamine, 3-triethoxysilylpropyl-5,5-dimethylhydantoin(NSi), was prepared and the structures of product were characterized. In the meantime, a modified layer made by poly ethylene glycol diglycidyl ether (PEGDE) was prepared and its stability after chlorination was evaluated. Based upon the results obtained above, the finishing agents prepared by NSi and PEGDE solution were applied to cotton fibers by pad-dry process. The textiles obtained were characterized using a variety of testing methods. It was noted that the fabric modified via PEGDE and NSi showed higher hydrophilicity, less bacterial adhesion. Antimicrobial tests exhibited that the treated cotton possessed sufficient antibacterial properties against Staphylococcus aureus and Escherichia coli. It stays valid even though times washing. In conclusion, this work successfully fabricated a rechargeable and washable cotton surface with bactericidal/antibacterial adhesion characteristics by simply pad-dry process.

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