鑑定呼氣成分中的指標性氣體可以明白人體新陳代謝的疾病與代謝狀況。糖尿病為現代人所困擾的疾病，此類患者呼氣成分中的丙酮濃度會高於健康者，因此可將丙酮視為糖尿病診斷的指標。本研究發展固態高分子電解質型丙酮氣體感測器，並將之應用於臨床方面，以找出糖尿病患者呼氣成分中的丙酮濃度與血糖濃度之間的關係或與醫師合作直接用丙酮濃度診斷糖尿病。此外，也成功地與微小型恆電位儀作整合，使此種非侵入式感測器在未來微小化及商品化更具可行性。
固態高分子電解質型丙酮氣體感測器由工作電極（鉛）、參考電極（改良式銀／氯化銀）、輔助電極（白金）及含有奈米級二氧化矽與離子液體BMIPF6　的PVdF(HFP)固態高分子電解質所構成。
感測電流訊號會受到固態高分子電解質組成之離子液體／高分子重量比、奈米級二氧化矽添加量及厚度所影響。當感測器由施加90V偏壓真空濺鍍製成之鉛工作電極，離子液體／高分子重量比為2與20wt%奈米級二氧化矽及50mL溶劑之高分子電解質所構成；感測條件為施加電位-0.9V（vs. 改良式銀／氯化銀參考電極），氣體流速為25mL/min時，有最佳的感測性質：結果顯示，丙酮濃度1~100ppm的感測靈敏度為0.2830 µAcm-2ppm-1；丙酮濃度100~250ppm的感測靈敏度為0.5933 µAcm-2ppm-1，平均應答時間約為60秒，感測極限可達1ppm。
　　在臨床應用方面可將糖尿病患者與健康者作區別，也成功地與微小型恆電位儀作整合，其整合的結果與商業大型恆電位儀訊號差異在25 %以內，使未來商品化及微小化更具有潛力。

The solid polymer electrolyte-based acetone gas sensor has been developed in order to diagnose diabetes. The main characteristics of diabetes are a lack of insulin and a high concentration of blood sugar. These phenomena can result in an increased production of fatty acids, which are then converted into ketone bodies. Acetone is the final product of the metabolism of the ketone bodies; thus, a rapid and quantitative determination of acetone in expired air is important and useful for the diagnosis of diabetes.
In this study, the sputtered lead working electrode prepared with 90V bias voltage in the sputter chamber. The polymer electrolyte with BMIPF6/PVdF(HFP) weight ratio equal to 2, with 20wt% nano SiO2 and with 50mL solvent was used as solid polymer electrolyte. Platinum and modified Ag/AgCl were used as counter and reference electrodes, respectively. The applied voltage and gas flow rate were -0.9V vs. modified Ag/AgCl reference electrode and 25mL/min, respectively. .
The response current was affected by the ionic liquid/polymer weight ratio, the amount of nano SiO2 and the thickness of the polymer electrolyte. The result indicated that the acetone gas sensor showed good reproducibility and high sensitivity: 0.2030µAcm-2ppm-1 in the detection range from 1 to 100ppm and 0.5933µAcm-2ppm-1 in the detection range from 100 to 250ppm. Two linear relationships between the current density and the concentration of acetone in low and high concentration regions were obtained. The average response time was 60sec, and limit detection concentration was 1ppm.
In clinical application, we measured the expired air of diabetic patients to find out the initial relationship between concentration of blood sugar and acetone. By using the developed acetone sensor, the differences of acetone responses between diabetic patients and healthy person were obtained. The sensor was also successfully integrated with the homemade potentiostat. To commercialize this developed acetone sensing system is potential.

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