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研究生: 陳巧榕
Chen, Chiao-Jung
論文名稱: 社區老年人身體衰弱與口腔功能低下之關係及其對住院和跌倒之影響
Impact of physical frailty and oral hypofunction on hospitalization and falls among community-dwelling older adults
指導教授: 陳嬿今
Chen, Yen-Chin
王靜枝
Wang, Jing-Jy
學位類別: 碩士
Master
系所名稱: 醫學院 - 護理學系
Department of Nursing
論文出版年: 2025
畢業學年度: 114
語文別: 中文
論文頁數: 73
中文關鍵詞: 老年人口腔功能低下身體衰弱住院跌倒
外文關鍵詞: older adults, oral hypofunction, physical frailty, hospitalization, falls
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  • 背景:隨著平均壽命延長,台灣預計於2025年邁入超高齡社會。年齡增長導致多重生理功能衰退,降低對壓力的調節能力,使老年人脆弱性增加,表現為口腔與身體衰弱,進而引發各種健康不良結果。現有研究多聚焦於口腔功能低下與身體衰弱對認知衰退、老年憂鬱、生活品質下降、失能及死亡等影響,但住院及跌倒風險的實證資料仍不足。
    研究目的:分析社區老年人衰弱的比率,探討口腔功能低下與身體衰弱指標之相關以及其對住院及跌倒的影響。
    研究方法:採前瞻性研究設計,以方便取樣於台灣6個社區收案65歲以上老年人,測量以下七項口腔功能低下,包括:口腔衛生、口乾、咬合力、口腔輪替運動、舌壓、咀嚼及吞嚥功能,以手握力作為身體衰弱評估,健康不良結果則以住院和跌倒情形作為指標。口腔功能低下與身體衰弱間的關係以皮爾森積差相關分析,最後以多變項羅吉斯迴歸分析口腔功能低下、身體衰弱與住院、跌倒之勝算比。
    研究結果:此研究共收案179位(平均年齡74.2歲,女性占70.9%)。約有63.1%的老年人有口腔功能低下,34.6%有身體衰弱,23.5%合併口腔功能低下與身體衰弱。衰弱指標間關聯顯示舌壓、吞嚥功能與握力存在顯著正向關聯(p<0.05),而咀嚼困難是獨立住院風險因子(OR=1.169, 95% CI 1.013-1.348, p=0.032)。衰弱程度與跌倒並無顯著相關,然咀嚼能力對跌倒影響接近統計顯著差異(OR=1.143, 95% CI 0.998-1.309, p=0.054)。
    研究結論:社區老年人口腔功能低下與身體衰弱盛行率偏高,且兩者存在顯著正向相關,當兩者並存時顯著增加住院風險,而咀嚼能力是獨立預測因子。結果支持將口腔功能納入衰弱評估的重要性,並提醒社區需重視口腔健康在預防住院與維護高齡者整體健康中的關鍵角色。

    Frailty in later life has emerged as a critical public health concern as global societies enter an era of accelerated population aging. Both physical frailty and oral hypofunction represent interconnected manifestations of age-related physiological decline, yet their combined influence on adverse health outcomes—particularly hospitalization and falls—remains insufficiently understood. This prospective community-based study investigated the prevalence of oral hypofunction and physical frailty among Taiwanese older adults, explored the correlations among frailty indicators, and examined their association with hospitalization and falls. A total of 179 participants aged ≥65 years were recruited from six communities. Oral hypofunction was assessed using seven standardized indicators, and physical frailty was evaluated using handgrip strength. Logistic regression models were applied to determine the predictive effects on hospitalization and falls. Findings revealed high prevalence of oral hypofunction (63.1%) and physical frailty (34.6%), with 23.5% exhibiting both conditions. Tongue pressure, swallowing function, and handgrip strength demonstrated significant positive correlations. Chewing difficulty independently predicted hospitalization risk, and its association with falls approached significance. These results highlight the necessity of integrating oral function assessment into frailty screening and community health strategies.

    摘要 i 第壹章 緒論 1 第一節 研究背景與動機 1 第二節 研究目的 3 第三節 研究假說 3 第貳章 文獻查證 4 第一節 老化導致衰弱及健康不良結果 4 第二節 身體衰弱與健康不良結果的關係 5 第三節 口腔功能與健康不良結果的關係 9 第四節 口腔功能與身體衰弱的關係及對健康不良結果的影響 16 第參章 研究設計及方法 20 第一節 研究設計及架構 20 第二節 研究變項與測量工具 20 第三節 收案步驟及流程 26 第四節 研究過程中倫理考量 27 第五節 統計分析 28 第肆章 研究結果分析 29 第一節 受試者基本人口學資料 29 第二節 不同年齡與衰弱狀態之口腔功能差異 33 第三節 口腔功能與身體衰弱之相關 35 第四節 口腔功能低下與身體衰弱對住院之影響 37 第五節 口腔功能低下與身體衰弱對跌倒之影響 39 第伍章 討論 41 第一節 社區老年人口腔功能低下與身體衰弱之分布 41 第二節 社區老年人口腔功能低下與身體衰弱之相關性 43 第三節 社區老年人口腔功能低下與身體衰弱對住院影響 44 第四節 社區老年人口腔功能低下與身體衰弱對跌倒影響 45 第陸章 研究限制 46 第柒章 結論與建議 47 第一節 結論 47 第二節 建議 47 參考文獻 48

    內政部(2025,11月15日).縣市人口年齡結構指標。https://www.ris.gov.tw/app/portal/346
    Adams, V., Mathisen, B., Baines, S., Lazarus, C., & Callister, R. (2015). Reliability of measurements of tongue and hand strength and endurance using the Iowa oral performance instrument with elderly adults. Disability and Rehabilitation, 37(5), 389-395. https://doi.org/10.3109/09638288.2014.92124
    Adeyemi, O., Grudzen, C., DiMaggio, C., Wittman, I., Velez-Rosborough, A., Arcila-Mesa, M., Cuthel, A., Poracky, H., Meyman, P., & Chodosh, J. (2025). Pre-injury frailty and clinical care trajectory of older adults with trauma injuries: A retrospective cohort analysis of a large level I US trauma center. Public Library of Science One, 20(2), e0317305. https://doi.org/10.1371/journal.pone.0317305
    Aguilar-Navarro, S. G., Amieva, H., Gutiérrez-Robledo, L. M., & Avila-Funes, J. A. (2015). Frailty among Mexican community-dwelling elderly: A story told 11 years later. The Mexican health and aging study. Salud publica de Mexico, 57, s62-s69. https://doi.org/10.21149/spm.v57s1.7591
    Aida, J., Kondo, K., Hirai, H., Nakade, M., Yamamoto, T., Hanibuchi, T., Osaka, K., Sheiham, A., Tsakos, G., & Watt, R. G. (2012). Association between dental status and incident disability in an older Japanese population. Journal of the American Geriatrics Society, 60(2), 338-343. https://doi.org/10.1111/j.1532-5415.2011.03791.x
    Alley, D. E., Shardell, M. D., Peters, K. W., McLean, R. R., Dam, T.-T. L., Kenny, A. M., Fragala, M. S., Harris, T. B., Kiel, D. P., & Guralnik, J. M. (2014). Grip strength cutpoints for the identification of clinically relevant weakness. Journals of Gerontology Series A: Biomedical Sciences and Medical Sciences, 69(5), 559-566. https://doi.org/10.1093/gerona/glu011
    Arakawa‐Kaneko, I., Watarai, Y., Schimmel, M., & Abou‐Ayash, S. (2022). Relationship between tongue pressure and handgrip strength: A systematic review and meta‐analysis. Journal of Oral Rehabilitation, 49(11), 1087-1105. https://doi.org/10.1111/joor.13362
    Avila-Funes, J. A., Helmer, C., Amieva, H., Barberger-Gateau, P., Goff, M. L., Ritchie, K., Portet, F., Carrière, I., Tavernier, B., & Gutiérrez-Robledo, L. M. (2008). Frailty among community-dwelling elderly people in France: The three-city study. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 63(10), 1089-1096. https://doi.org/10.1093/gerona/63.10.1089
    Bandeen-Roche, K., Seplaki, C. L., Huang, J., Buta, B., Kalyani, R. R., Varadhan, R., Xue, Q. L., Walston, J. D., & Kasper, J. D. (2015). Frailty in older adults: A nationally representative profile in the united states. The journals of gerontology. Series A, Biological sciences and medical sciences, 70(11), 1427-1434. https://doi.org/10.1093/gerona/glv133
    Belafsky, P. C., Mouadeb, D. A., Rees, C. J., Pryor, J. C., Postma, G. N., Allen, J., & Leonard, R. J. (2008). Validity and reliability of the eating assessment tool (EAT-10). Annals of Otology, Rhinology & Laryngology, 117(12), 919-924. https://doi.org/10.1177/000348940811701210
    Bernabei, R., Martone, A. M., Vetrano, D. L., Calvani, R., Landi, F., & Marzetti, E. (2014). Frailty, physical frailty, sarcopenia: A new conceptual model. Stud Health Technol Inform, 203, 78-84. https://doi.org/10.3233/978-1-61499-425-1-78
    Bortone, I., Sardone, R., Lampignano, L., Castellana, F., Zupo, R., Lozupone, M., Moretti, B., Giannelli, G., & Panza, F. (2021). How gait influences frailty models and health‐related outcomes in clinical‐based and population‐based studies: A systematic review. Journal of cachexia, sarcopenia and muscle, 12(2), 274-297. https://doi.org/10.1002/jcsm.12667
    Callahan, C. M., Unverzagt, F. W., Hui, S. L., Perkins, A. J., & Hendrie, H. C. (2002). Six-item screener to identify cognitive impairment among potential subjects for clinical research. Medical Care, 40(9), 771-781. https://doi.org/10.1097/00005650-200209000-00007
    Carmeli, E. (2017). Frailty and primary sarcopenia: A review. Advances in Experimental Medicine and Biology, 1020, 53-68. https://doi.org/10.1007/5584_2017_18
    Castrejón-Pérez, R. C., Jiménez-Corona, A., Bernabé, E., Villa-Romero, A. R., Arrivé, E., Dartigues, J.-F., Gutiérrez-Robledo, L. M., & Borges-Yáñez, S. A. (2017). Oral disease and 3-year incidence of frailty in Mexican older adults. Journals of Gerontology Series A: Biomedical Sciences and Medical Sciences, 72(7), 951-957. https://doi.org/10.1093/gerona/glw201
    Chang, S. F., Lin, H. C., & Cheng, C. L. (2018). The relationship of frailty and hospitalization among older people: Evidence from a meta‐analysis. Journal of Nursing Scholarship, 50(4), 383-391. https://doi.org/10.1111/jnu.12397
    Chen, Y. C., Ku, E. N., Lin, C. W., Tsai, P. F., Wang, J. L., Yen, Y. F., Ko, N. Y., Ko, W. C., & Lee, N. Y. (2024). Tongue pressure during swallowing is an independent risk factor for aspiration pneumonia in middle‐aged and older hospitalized patients: An observational study. Geriatrics & gerontology international, 24, 351-357. https://doi.org/10.1111/ggi.14769
    da Mata, C., Allen, P. F., McKenna, G. J., Hayes, M., & Kashan, A. (2019). The relationship between oral‐health‐related quality of life and general health in an elderly population: A cross‐sectional study. Gerodontology, 36(1), 71-77. https://doi.org/10.1111/ger.12384
    Dahlberg, L., Agahi, N., Schön, P., & Lennartsson, C. (2018). Planned and unplanned hospital admissions and their relationship with social factors: Findings from a national, prospective study of people aged 76 years or older. Health Services Research, 53(6), 4248-4267. https://doi.org/10.1111/1475-6773.13001
    de Barros Lima Martins, A. M. E., Nascimento, J. E., Souza, J. G. S., Sales, M. M., Jones, K. M., & Ferreira e Ferreira, E. (2016). Associations between oral disorders and the quality of life of older adults in B razil. Geriatrics & gerontology international, 16(4), 446-457. https://doi.org/10.1111/ggi.12489
    Dibello, V., Lobbezoo, F., Lozupone, M., Sardone, R., Ballini, A., Berardino, G., Mollica, A., Coelho-Junior, H. J., De Pergola, G., & Stallone, R. (2023). Oral frailty indicators to target major adverse health-related outcomes in older age: A systematic review. Geroscience, 45(2), 663-706. https://doi.org/10.1007/s11357-022-00663-8
    Elsig, F., Schimmel, M., Duvernay, E., Giannelli, S. V., Graf, C. E., Carlier, S., Herrmann, F. R., Michel, J. P., Gold, G., & Zekry, D. (2015). Tooth loss, chewing efficiency and cognitive impairment in geriatric patients. Gerodontology, 32(2), 149-156. https://doi.org/10.1111/ger.12079
    Fedarko, N. S. (2011). The biology of aging and frailty. Clinics in Geriatric Medicine, 27(1), 27-37. https://doi.org/10.1016/j.cger.2010.08.006
    Fried, L. P., Tangen, C. M., Walston, J., Newman, A. B., Hirsch, C., Gottdiener, J., Seeman, T., Tracy, R., Kop, W. J., Burke, G., & McBurnie, M. A. (2001). Frailty in older adults: Evidence for a phenotype. The journals of gerontology. Series A, Biological sciences and medical sciences, 56(3), M146-156. https://doi.org/10.1093/gerona/56.3.m146
    Ganz, D. A., Bao, Y., Shekelle, P. G., & Rubenstein, L. Z. (2007). Will my patient fall? Jama, 297(1), 77-86. https://doi.org/10.1001/jama.297.1.77
    Hägglund, P., Koistinen, S., Olai, L., Ståhlnacke, K., Wester, P., & Levring Jäghagen, E. (2019). Older people with swallowing dysfunction and poor oral health are at greater risk of early death. Community Dentistry and Oral Epidemiology, 47(6), 494-501. https://doi.org/10.1111/cdoe.12491
    Hamada, T., Kubo, T., Kawai, K., Nakaoka, Y., Yabe, T., Furuno, T., Yamada, E., Kitaoka, H., & study, K. Y. (2021). Frailty in patients with acute decompensated heart failure in a super‐aged regional Japanese cohort. European Society of Cardiology Heart Failure, 8(4), 2876-2888. https://doi.org/10.1002/ehf2.13363
    Hara, K., Tohara, H., Kenichiro, K., Yamaguchi, K., Ariya, C., Yoshimi, K., Nakane, A., & Minakuchi, S. (2019). Association between tongue muscle strength and masticatory muscle strength. Journal of Oral Rehabilitation, 46(2), 134-139. https://doi.org/10.1111/joor.12737
    Hatanaka, Y., Furuya, J., Sato, Y., Uchida, Y., Shichita, T., Kitagawa, N., & Osawa, T. (2021). Associations between oral hypofunction tests, age, and sex. International journal of environmental research and public health, 18(19), 10256. https://doi.org/10.3390/ijerph181910256
    Hihara, T., Goto, T., & Ichikawa, T. (2020). Assessment of potential clinical cascade between oral hypofunction and physical frailty: Covariance structure analysis in a cross-sectional study. Journal of Oral Rehabilitation, 47(1), 61-66. https://doi.org/10.1111/joor.12862
    Hiltunen, K., Saarela, R. K., Kautiainen, H., Roitto, H.-M., Pitkälä, K. H., & Mäntylä, P. (2021). Relationship between Fried’s frailty phenotype and oral frailty in long-term care residents. Age and Ageing, 50(6), 2133-2139. https://doi.org/10.1093/ageing/afab177
    Holloszy, J. O. (2000). The biology of aging. Mayo Clinic Proceedings 75(1), S3-S9. https://doi.org/10.1016/S0025-6196(19)30634-2
    Horibe, Y., Matsuo, K., Ikebe, K., Minakuchi, S., Sato, Y., Sakurai, K., & Ueda, T. (2022). Relationship between two pressure‐sensitive films for testing reduced occlusal force in diagnostic criteria for oral hypofunction. Gerodontology, 39(1), 3-9. https://doi.org/10.1111/ger.12538
    Hsu, K. J., Lee, H. E., Lan, S. J., Huang, S. T., Chen, C. M., & Yen, Y. Y. (2012). Evaluation of a self‐assessed screening test for masticatory ability of Taiwanese older adults. Gerodontology, 29(2), e1113-e1120. https://doi.org/10.1111/j.1741-2358.2012.00632.x
    Hu, H.-Y., Lee, Y.-L., Lin, S.-Y., Chou, Y.-C., Chung, D., Huang, N., Chou, Y.-J., & Wu, C.-Y. (2015). Association between tooth loss, body mass index, and all-cause mortality among elderly patients in Taiwan. Medicine, 94(39), e1543. https://doi.org/10.1097/MD.0000000000001543
    Iwasaki, M., & Hirano, H. (2022). Decline in oral function and its management. International Dental Journal, 72(4), S12-S20. https://doi.org/10.1016/j.identj.2022.06.010
    Iwasaki, M., Kimura, Y., Sasiwongsaroj, K., Kettratad‐Pruksapong, M., Suksudaj, S., Ishimoto, Y., Chang, N. Y., Sakamoto, R., Matsubayashi, K., & Songpaisan, Y. (2018). Association between objectively measured chewing ability and frailty: A cross‐sectional study in central Thailand. Geriatrics & gerontology international, 18(6), 860-866. https://doi.org/10.1111/ggi.13264
    Iwasaki, M., Yoshihara, A., Sato, N., Sato, M., Taylor, G., Ansai, T., Ono, T., & Miyazaki, H. (2016). Maximum bite force at age 70 years predicts all‐cause mortality during the following 13 years in Japanese men. Journal of Oral Rehabilitation, 43(8), 565-574. https://doi.org/10.1111/joor.12401
    Khadka, S., Khan, S., King, A., Goldberg, L. R., Crocombe, L., & Bettiol, S. (2021). Poor oral hygiene, oral microorganisms and aspiration pneumonia risk in older people in residential aged care: A systematic review. Age and Ageing, 50(1), 81-87. https://doi.org/10.1093/ageing/afaa102
    Khan, K. T., Hemati, K., & Donovan, A. L. (2019). Geriatric physiology and the frailty syndrome. Anesthesiology clinics, 37(3), 453-474. https://doi.org/10.1016/j.anclin.2019.04.006
    Kim, D. H., & Rockwood, K. (2024). Frailty in older adults. New England Journal of Medicine, 391(6), 538-548. https://doi.org/10.1056/NEJMra2301292
    Komatsu, R., Nagai, K., Hasegawa, Y., Okuda, K., Okinaka, Y., Wada, Y., Tsuji, S., Tamaki, K., Kusunoki, H., & Kishimoto, H. (2021). Association between physical frailty subdomains and oral frailty in community-dwelling older adults. International journal of environmental research and public health, 18(6), 2931. https://doi.org/10.3390/ijerph18062931
    Kotronia, E., Brown, H., Papacosta, O., Lennon, L. T., Weyant, R. J., Whincup, P. H., Wannamethee, S. G., & Ramsay, S. E. (2022). Oral health problems and risk of incident disability in two studies of older adults in the United Kingdom and the United States. Journal of the American Geriatrics Society, 70(7), 2080-2092. https://doi.org/10.1111/jgs.17792
    Kugimiya, Y., Iwasaki, M., Ohara, Y., Motokawa, K., Edahiro, A., Shirobe, M., Watanabe, Y., Obuchi, S., Kawai, H., Fujiwara, Y., Ihara, K., Kim, H., Ueda, T., & Hirano, H. (2021). Relationship between oral hypofunction and sarcopenia in community-dwelling older adults: The otassha study. International Journal of Environmental Research and Public Health, 18(12). https://doi.org/10.3390/ijerph18126666
    Kuo, Y. W., & Lee, J. D. (2022). Association between oral frailty and physical frailty among rural middle-old community-dwelling people with cognitive decline in Taiwan: A cross-sectional study. International Journal of Environmental Research and Public Health, 19(5). https://doi.org/10.3390/ijerph19052884
    Lin, Y. C., Du, J. K., Lin, P. C., Kabasawa, Y., Lin, P. L., Hsiao, S. Y., & Huang, H. L. (2021). Association between the dental occlusion and perceived ability to eat foods of Taiwanese older adults. Journal of Oral Rehabilitation, 48(7), 817-826. https://doi.org/10.1111/joor.13160
    Lin, Y. C., Huang, S. S., Yen, C. W., Kabasawa, Y., Lee, C. H., & Huang, H. L. (2022). Physical frailty and oral frailty associated with late-life depression in community-dwelling older adults. Journal of Personalized Medicine, 12(3). https://doi.org/10.3390/jpm12030459
    Liu, B., Dion, M. R., Jurasic, M. M., Gibson, G., & Jones, J. A. (2012). Xerostomia and salivary hypofunction in vulnerable elders: Prevalence and etiology. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 114(1), 52-60. https://doi.org/10.1016/j.oooo.2011.11.014
    Liu, J., Fujii, Y., Fujii, K., Seol, J., Nagata, K., & Okura, T. (2025). Mediating role of frailty/pre‑frailty on the association between exercise participation and traffic crashes among Japanese community‑dwelling older drivers. BMC Geriatrics, 25(1), 341. https://doi.org/10.1186/s12877-025-05998-3
    Liu, L. F. (2014). The health heterogeneity of and health care utilization by the elderly in Taiwan. International Journal of Environmental Research and Public Health, 11(2), 1384-1397. https://doi.org/10.3390/ijerph110201384
    Löfgren, C. D., Wickström, C., Sonesson, M., Lagunas, P. T., & Christersson, C. (2012). A systematic review of methods to diagnose oral dryness and salivary gland function. BMC oral health, 12, 1-16. https://doi.org/10.1186/1472-6831-12-29
    Matsuyama, Y., Aida, J., Watt, R., Tsuboya, T., Koyama, S., Sato, Y., Kondo, K., & Osaka, K. (2017). Dental status and compression of life expectancy with disability. Journal of dental research, 96(9), 1006-1013. https://doi.org/10.1177/0022034517713166
    McGrath, R. P., Kraemer, W. J., Snih, S. A., & Peterson, M. D. (2018). Handgrip strength and health in aging adults. Sports medicine, 48, 1993-2000. https://doi.org/10.1007/s40279-018-0952-y
    Mehmet, H., Yang, A. W., & Robinson, S. R. (2020). Measurement of hand grip strength in the elderly: A scoping review with recommendations. Journal of bodywork and movement therapies, 24(1), 235-243. https://doi.org/10.1016/j.jbmt.2019.05.029
    Mihara, Y., Matsuda, K. i., Ikebe, K., Hatta, K., Fukutake, M., Enoki, K., Ogawa, T., Takeshita, H., Inomata, C., & Gondo, Y. (2018). Association of handgrip strength with various oral functions in 82‐to 84‐year‐old community‐dwelling Japanese. Gerodontology, 35(3), 214-220. https://doi.org/10.1111/ger.12341
    Min, S.-Y., Pang, N.-S., Kim, Y.-R., Jeong, S.-A., & Jung, B.-Y. (2024). Factors associated with age-related changes in oral diadochokinesis and masticatory function in healthy old adults. BMC oral health, 24(1), 462. https://doi.org/10.1186/s12903-024-04214-9
    Minakuchi, S., Tsuga, K., Ikebe, K., Ueda, T., Tamura, F., Nagao, K., Furuya, J., Matsuo, K., Yamamoto, K., Kanazawa, M., Watanabe, Y., Hirano, H., Kikutani, T., & Sakurai, K. (2018). Oral hypofunction in the older population: Position paper of the Japanese society of gerodontology in 2016. Gerodontology, 35(4), 317-324. https://doi.org/10.1111/ger.12347
    Mochida, Y., Yamamoto, T., Fuchida, S., Aida, J., & Kondo, K. (2018). Does poor oral health status increase the risk of falls?: The JAGES project longitudinal study. PloS one, 13(2), e0192251. https://doi.org/10.1371/journal.pone.0192251
    Moriya, S., Tei, K., Harada, E., Murata, A., Muramatsu, M., Inoue, N., & Miura, H. (2011). Self-assessed masticatory ability and hospitalisation costs among the elderly living independently. Journal of Oral Rehabilitation, 38(5), 321-327. https://doi.org/10.1111/j.1365-2842.2010.02163.x
    Mossello, E., Profili, F., Di Bari, M., Bandinelli, S., Razzanelli, M., Salvioni, A., Corridori, C., Di Fiandra, T., & Francesconi, P. (2016). Postal screening can identify frailty and predict poor outcomes in older adults: Longitudinal data from INTER-FRAIL study. Age and Ageing, 45(4), 469-474. https://doi.org/ 10.1093/ageing/afw048
    Motoishi, Y., Yamanashi, H., Kitamura, M., Hayashida, H., Kawasaki, K., Nobusue, K., Nonaka, F., Honda, Y., Shimizu, Y., & Kawashiri, S. y. (2021). Oral health‐related quality of life is associated with physical frailty: A cross‐sectional study of Japanese community‐dwelling older adults. Journal of General and Family Medicine, 22(5), 271-277. https://doi.org/10.1002/jgf2.450
    Murotani, Y., Hatta, K., Takahashi, T., Gondo, Y., Kamide, K., Kabayama, M., Masui, Y., Ishizaki, T., Matsuda, K.-i., & Mihara, Y. (2021). Oral functions are associated with muscle strength and physical performance in old-old Japanese. International journal of environmental research and public health, 18(24), 13199. https://doi.org/10.3390/ijerph182413199
    Nakamura, M., Hamada, T., Tanaka, A., Nishi, K., Kume, K., Goto, Y., Beppu, M., Hijioka, H., Higashi, Y., Tabata, H., Mori, K., Mishima, Y., Uchino, Y., Yamashiro, K., Matsumura, Y., Makizako, H., Kubozono, T., Tabira, T., Takenaka, T.,…Sugiura, T. (2021). Association of oral hypofunction with frailty, sarcopenia, and mild cognitive impairment: A cross-sectional study of community-dwelling Japanese older adults. Journal of Clinical Medicine, 10(8). https://doi.org/10.3390/jcm10081626
    O'Caoimh, R., Galluzzo, L., Rodríguez-Laso, Á., Van der Heyden, J., Ranhoff, A. H., Lamprini-Koula, M., Ciutan, M., López-Samaniego, L., Carcaillon-Bentata, L., Kennelly, S., & Liew, A. (2018). Prevalence of frailty at population level in European ADVANTAGE joint action member states: A systematic review and meta-analysis. Annali dell'Istituto Superiore di Sanità, 54(3), 226-238. https://doi.org/10.4415/ann_18_03_10
    O’Caoimh, R., Sezgin, D., O’Donovan, M. R., Molloy, D. W., Clegg, A., Rockwood, K., & Liew, A. (2021). Prevalence of frailty in 62 countries across the world: A systematic review and meta-analysis of population-level studies. Age and Ageing, 50(1), 96-104. https://doi.org/10.1093/ageing/afaa219
    Ogawa, M., Satomi-Kobayashi, S., Yoshida, N., Tsuboi, Y., Komaki, K., Nanba, N., Izawa, K. P., Sakai, Y., Akashi, M., & Hirata, K.-i. (2021). Relationship between oral health and physical frailty in patients with cardiovascular disease. Journal of Cardiology, 77(2), 131-138. https://doi.org/10.1016/j.jjcc.2020.07.016
    Ohi, T., Komiyama, T., Miyoshi, Y., Murakami, T., Tsuboi, A., Tomata, Y., Tsuji, I., Watanabe, M., & Hattori, Y. (2018). Maximum occlusal force and incident functional disability in older adults: The Tsurugaya project. JDR Clinical & Translational Research, 3(2), 195-202. https://doi.org/10.1177/2380084418761329
    Ono, T., Kumakura, I., Arimoto, M., Hori, K., Dong, J., Iwata, H., Nokubi, T., Tsuga, K., & Akagawa, Y. (2007). Influence of bite force and tongue pressure on oro‐pharyngeal residue in the elderly. Gerodontology, 24(3), 143-150. https://doi.org/10.1111/j.1741-2358.2007.00172.x
    Op het Veld, L. P., van Rossum, E., Kempen, G. I., de Vet, H. C., Hajema, K., & Beurskens, A. J. (2015). Fried phenotype of frailty: Cross-sectional comparison of three frailty stages on various health domains. BMC Geriatrics, 15, 77. https://doi.org/10.1186/s12877-015-0078-0
    Panhale, V., Kini, R., & Kothale, S. (2025). Reliability and validity of Camry dynamometer for isometric hand grip strength measurement in healthy Indian adults. Journal of Hand and Microsurgery, 17(4), 100291. https://doi.org/10.1016/j.jham.2025.100291
    Parisius, K. G. H., Wartewig, E., Schoonmade, L. J., Aarab, G., Gobbens, R., & Lobbezoo, F. (2022). Oral frailty dissected and conceptualized: A scoping review. Archives of Gerontology and Geriatrics, 100, 104653. https://doi.org/10.1016/j.archger.2022.104653
    Pasquet, R., Xu, M., Sylvestre, M.-P., & Keezer, M. R. (2024). Comparison of three frailty measures for predicting hospitalization and mortality in the Canadian longitudinal study on aging. Aging Clinical and Experimental Research, 36(1), 48. https://doi.org/10.1007/s40520-024-02706-w
    Persson, E., Wårdh, I., & Östberg, P. (2019). Repetitive saliva swallowing test: Norms, clinical relevance and the impact of saliva secretion. Dysphagia, 34, 271-278. https://doi.org/10.1007/s00455-018-9937-0
    Pinto, M., Martins, S., Mesquita, E., & Fernandes, L. (2022). Frailty in Portuguese older patients from convalescence units: A cross-sectional study. Journal of Clinical Medicine Research, 14(9), 364. https://doi.org/10.14740/jocmr4806
    Qin, Y., Hao, X., Lv, M., Zhao, X., Wu, S., & Li, K. (2023). A global perspective on risk factors for frailty in community-dwelling older adults: A systematic review and meta-analysis. Archives of gerontology and geriatrics, 105, 104844. https://doi.org/10.1016/j.archger.2022.104844
    Ramsay, S. E., Papachristou, E., Watt, R. G., Tsakos, G., Lennon, L. T., Papacosta, A. O., Moynihan, P., Sayer, A. A., Whincup, P. H., & Wannamethee, S. G. (2018). Influence of poor oral health on physical frailty: A population‐based cohort study of older British men. Journal of the American Geriatrics Society, 66(3), 473-479. https://doi.org/10.1111/jgs.15175
    Robin, D. A., Goel, A., Somodi, L. B., & Luschei, E. S. (1992). Tongue strength and endurance: Relation to highly skilled movements. Journal of Speech, Language, and Hearing Research, 35(6), 1239-1245. https://doi.org/
    Sakaguchi, K., & Hara, S. (2022). Association of oral diadochokinesis, physical function and swallowing function in community-dwelling elderly people. Advances in Aging Research, 11(1), 16-25. https://doi.org/10.1044/jshr.3506.1239
    Sasegbon, A., & Hamdy, S. (2017). The anatomy and physiology of normal and abnormal swallowing in oropharyngeal dysphagia. Neurogastroenterol Motil, 29(11). https://doi.org/10.1111/nmo.13100
    Shen, J., Qian, S., Huang, L., Tao, Y., Chen, H., Deng, K., Yang, F., Zong, G., Zheng, Y., Wang, X., Tonetti, M., & Yuan, C. (2023). Association of the number of natural teeth with dietary diversity and nutritional status in older adults: A cross-sectional study in China. Journal of Clinical Periodontology, 50(2), 242-251. https://doi.org/10.1111/jcpe.13728
    Shim, E. Y., Ma, S. H., Hong, S. H., Lee, Y. S., Paik, W. Y., Seo, D. S., Yoo, E. Y., Kim, M. Y., & Yoon, J. L. (2011). Correlation between frailty level and adverse health-related outcomes of community-dwelling elderly, one year retrospective study. Korean journal of family medicine, 32(4), 249. https://doi.org/10.4082/kjfm.2011.32.4.249
    Shimazaki, Y., Nonoyama, T., Tsushita, K., Arai, H., Matsushita, K., & Uchibori, N. (2020). Oral hypofunction and its association with frailty in community‐dwelling older people. Geriatrics & gerontology international, 20(10), 917-926. https://doi.org/10.1111/ggi.14015
    Shimizu, A., Fujishima, I., Maeda, K., Wakabayashi, H., Nishioka, S., Ohno, T., Nomoto, A., Shigematsu, T., Kayashita, J., & on Sarcopenic, T. J. W. G. (2021). Effect of low tongue pressure on nutritional status and improvement of swallowing function in sarcopenic dysphagia. Nutrition, 90, 111295. https://doi.org/10.1016/j.nut.2021.111295
    Shimizu, T., Ueda, T., & Sakurai, K. (2007). New method for evaluation of tongue‐coating status. Journal of Oral Rehabilitation, 34(6), 442-447. https://doi.org/10.1111/j.1365-2842.2007.01733.x
    Shiraishi, A., Yoshimura, Y., Wakabayashi, H., Tsuji, Y., Shimazu, S., & Jeong, S. (2019). Impaired oral health status on admission is associated with poor clinical outcomes in post-acute inpatients: A prospective cohort study. Clinical Nutrition, 38(6), 2677-2683. https://doi.org/10.1016/j.clnu.2018.11.020
    Simpson, K. N., Seamon, B. A., Hand, B. N., Roldan, C. O., Taber, D. J., Moran, W. P., & Simpson, A. N. (2018). Effect of frailty on resource use and cost for Medicare patients. Journal of comparative effectiveness research, 7(8), 817-825. https://doi.org/10.2217/cer-2018-0029
    Spiegowski, D., Metzger, L., Jain, A., Inchiosa, M. A., Jr., Weber, G., & Abramowicz, A. E. (2022). The utility of grip strength as a simplified measure of frailty in the older adult in the preoperative clinic. Cureus, 14(9), e28747. https://doi.org/10.7759/cureus.28747
    Srinarupat, J., Zaitsu, T., Oshiro, A., Prasertsom, P., Niyomsilp, K., Kawaguchi, Y., & Aida, J. (2022). Associations of the number of remaining natural teeth and oral health behaviors with subjective chewing problems based on the Thailand National Oral Health Survey 2017. Journal of Oral Science, 64(3), 190-193. https://doi.org/10.2334/josnusd.21-0486
    Sugaya, N., Goto, F., Okami, K., & Nishiyama, K. (2021). Association between swallowing function and muscle strength in elderly individuals with dysphagia. Auris Nasus Larynx, 48(2), 261-264. https://doi.org/10.1016/j.anl.2020.09.007
    Takehara, S., Karawekpanyawong, R., Okubo, H., Tun, T. Z., Ramadhani, A., Chairunisa, F., Tanaka, A., Wright, F. A. C., & Ogawa, H. (2023). Oral health promotion under the 8020 campaign in Japan-a systematic review. Int J Environ Res Public Health, 20(3). https://doi.org/10.3390/ijerph20031883
    Takeuchi, N., Sawada, N., Ekuni, D., & Morita, M. (2021). Oral diadochokinesis is related to decline in swallowing function among community-dwelling Japanese elderly: A cross-sectional study. Aging Clinical and Experimental Research, 33, 399-405. https://doi.org/10.1007/s40520-020-01547-7
    Tanaka, T., Takahashi, K., Hirano, H., Kikutani, T., Watanabe, Y., Ohara, Y., Furuya, H., Tetsuo, T., Akishita, M., & Iijima, K. (2018). Oral frailty as a risk factor for physical frailty and mortality in community-dwelling elderly. The Journals of Gerontology: Series A, 73(12), 1661-1667. https://doi.org/10.1093/gerona/glx225
    Trevisan, C., Noale, M., Amidei, C. B., Ferroni, E., Basso, C., Fedeli, U., Baggio, G., Maggi, S., & Sergi, G. (2023). Frailty and the risk of infection-related hospitalizations in older age: Differences by sex. Maturitas, 168, 1-6. https://doi.org/10.1016/j.maturitas.2022.10.009
    Trevisan, K., Cristina-Pereira, R., Silva-Amaral, D., & Aversi-Ferreira, T. A. (2019). Theories of aging and the prevalence of Alzheimer’s disease. BioMed research international, 2019(1), 9171424. https://doi.org/10.1155/2019/9171424
    United Nations, Department of Economic and Social Affairs, Population Division. (2022). World population prospects 2022. https://population.un.org/wpp/Download/Standard/Population/
    United Nations, Department of Economic and Social Affairs, Population Division. (2023, January). World social report 2023: Leaving no one behind in an aging world. https://www.un.org/development/desa/dspd/wp-content/uploads/sites/22/2023/01/WSR_2023_Chapter_Key_Messages.pdf
    Wakasugi, Y., Tohara, H., Machida, N., Nakane, A., & Minakuchi, S. (2017). Can grip strength and/or walking speed be simple indicators of the deterioration in tongue pressure and jaw opening force in older individuals? Gerodontology, 34(4), 455-459. https://doi.org/10.1111/ger.12292
    Wang, C., Fang, X., Tang, Z., Hua, Y., Zhang, Z., Gu, X., Liu, B., & Ji, X. (2022). A frailty index based on routine laboratory data predicts increased risk of mortality in Chinese community-dwelling adults aged over 55 years: A five-year prospective study. BMC geriatrics, 22(1), 679. https://doi.org/10.1186/s12877-022-03374-z
    Wang, J., Li, Y., Yang, G. Y., & Jin, K. (2024). Age-related dysfunction in balance: A comprehensive review of causes, consequences, and interventions. Aging and disease, 16(2), 714-737. https://doi.org/10.14336/ad.2024.0124-1
    World Health Organization. (2021). Falls. https://www.who.int/news-room/fact-sheets/detail/falls
    World Health Organization. (n.d.). Inpatient care discharges per 100. WHO European Health Information Gateway. https://gateway.euro.who.int/en/indicators/hfa_534-6010-inpatient-care-discharges-per-100/
    Wu, Y., Liu, H., Qin, Y., Chen, H., Ma, J., Yin, M., Shi, L., & Fu, Y. (2025). Association between multimorbidity and having less than 20 natural teeth among Chinese older adults: A cross-sectional study. Scientific Reports, 15(1), 7865. https://doi.org/10.1038/s41598-025-92426-6
    Xu, M., Gong, Y., & Yin, X. (2024). Association of frailty with risk of incident hospital-treated infections in middle-aged and older adults: A large-scale prospective cohort study.The journals of gerontology. Series A, Biological sciences and medical sciences, 79(8). https://doi.org/10.1093/gerona/glae146
    Yamamoto, T., Kondo, K., Misawa, J., Hirai, H., Nakade, M., Aida, J., Kondo, N., Kawachi, I., & Hirata, Y. (2012). Dental status and incident falls among older Japanese: A prospective cohort study. BMJ open, 2(4), e001262. https://doi.org/10.1136/bmjopen-2012-001262
    Yang, X., Lupón, J., Vidán, M. T., Ferguson, C., Gastelurrutia, P., Newton, P. J., Macdonald, P. S., Bueno, H., Bayés‐Genís, A., & Woo, J. (2018). Impact of frailty on mortality and hospitalization in chronic heart failure: A systematic review and meta‐analysis. Journal of the American Heart Association, 7(23), e008251. https://doi.org/10.1161/JAHA.117.008251
    Yoshida, M., Hiraoka, A., Takeda, C., Mori, T., Maruyama, M., Yoshikawa, M., & Tsuga, K. (2022). Oral hypofunction and its relation to frailty and sarcopenia in community-dwelling older people. Gerodontology, 39(1), 26-32. https://doi.org/10.1111/ger.12603
    Zhao, Z., Wang, Q., Zheng, X., An, N., Zhou, M., Niu, L., Tay, F. R., Chen, J., & Wang, F. (2022). Reliability and validity of two computerised occlusion analysis systems. Journal of Dentistry, 118, 104051. https://doi.org/10.1016/j.jdent.2022.104051
    Zhu, R. T.-L., Zuo, J. J.-J., Li, K.-J., Lam, F. M. H., Wong, A. Y. L., Yang, L., Bai, X., Wong, M. S., Kwok, T., & Zheng, Y.-P. (2025). Association of lower-limb strength with different fall histories or prospective falls in community-dwelling older people: A systematic review and meta-analysis. BMC geriatrics, 25(1), 83. https://doi.org/10.1186/s12877-025-05685-3

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