海馬迴(hippocampus)，前後長軸向是否有功能上之差異一直是個重要的議題。動物研究中發現老鼠海馬迴腹側(相對於人類海馬迴長軸向前端)的位置細胞(place cell)之位置域(place field)較背側(後端)來得大，但人類在這方面的相關證據卻仍不一致。Morgan等人(2011)利用fMRI適應效果（adaptation）的派典來研究人類海馬迴，其結果發現左側海馬迴前端所產生的適應效果與相鄰兩刺激地標間的距離呈線性關係，當相鄰兩刺激地標距離越近，其適應效果越大。在本研究中我們參照Morgan等人（2011）的研究派典並加以修改，以檢驗海馬迴前後側上位置細胞的活化反應之差異。在實驗一中，我們利用區間設計並加入更短距離配對之刺激，其結果發現海馬迴中、後側的活化反應隨著地標間距離變遠而有增強的趨勢。而在實驗二中我們採用Morgan等人的研究派典，並且增加了更短距離的地標刺激配對，結果發現海馬迴後側的活化反應則是與地標間距離遠近呈現顯著負相關。因此在本研究中的結果雖未如假設所推論當相鄰地標刺激越接近時會產生越大的適應效果，但研究結果另一方面卻是支持過去所認為海馬迴後側與負責處理細節資訊較有相關。

The hippocampus plays an important role in memory and spatial cognition. It acts like an inner GPS in the brain. It has been shown from animal studies that the areas along the long axis of the hippocampus may have different specialized functions. In rats, many studies have found that the size of place field of the place cells in the ventral hippocampus is larger than that in the dorsal hippocampus. Whether it is the same in humans remains unclear. In this study, we used the fMRI adaptation paradigm to explore how the distances between landmarks in the real world are represented in the hippocampus. In conclusion, we found the activation of the posterior hippocampus correlated with distances of consecutive landmarks presented.

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