癌症是近幾年來，國人十大死因之一，因此許多生醫上面的研究多著重於開發新技術應用於癌症的治療,而在本實驗室中希望結合奈米技術,分子模版技術與電噴霧技術以一創新化工技術希望在此研究領域有所突破。
以往的分子模版技術需經過繁複的程序,本實驗希望可以將目標分子與交聯劑,起始劑與功能性單體包覆在奈米磁性粒子表面再以電噴霧方式使此粒子表面帶電後在石英管中懸浮形成流體化床，在進行功能性單體的聚合後進行收集，此實驗裝置的優點是可以避免聚合後的奈米粒子產生聚集現象希望可得到單一顆粒生物分子包覆磁性奈米球，在應用於人體的癌症檢測上時將此生物分子磁性奈米球打入人體以分子與分子間的作用力去抓癌症細胞分子再以交直流磁場產生器使此磁性奈米球產生旋轉能或震動能與熱能進而殺死癌症細胞，利用變化電磁場使磁奈米粒子產生熱，並可控制在42~43℃，以此殺死癌細胞。此種癌症熱治療方式的表現及效率，與癌細胞的種類及磁奈米粒子的特性有關。因此如何掌控上述磁性奈米粒子的結構、大小、表面官能基物質、粒徑分佈是很重要的因素。
實驗結果顯示，在毛細管出口液滴的形狀會隨著施加的電壓大小而有所改變，當溶液導電度為90mS/cm，施加電壓範圍為1500V~4000V，在角椎噴射模式(cone-jet mode)下，製備出磁性複合奈米粒子的粒徑範圍約三十到九十奈米間，且具有良好的分散性，一般分子模版高分子所製備出的粒子粒徑大部分約為幾十微米左右，並且粒子間有聚集的現象產生，電噴霧法製備出的磁性複合奈米粒子可以改善以往製備分子模版所遭遇到的問題。
文獻得知，在流體化床內進行流體化的粒子粒徑範圍約在幾十到幾百微米間，本研究中利用電噴霧產生的帶電粒子進行流體化程序，由TEM 結果顯示出，流體化床內的帶電粒子粒徑可控制在100nm 以下，因此可以藉由電噴霧法製備出懸浮在流體化床中的奈米級粒子。
由實驗結果得知，空白矽基板與矽基板上收集有磁性複合殼核奈米粒子的螢光強度值分別為0.0049 與0.0872 a.u.，可以觀察出收集有磁性複合殼核奈米粒子的矽基板，其螢光強度有明顯的提高。因此藉由此實驗結果可以證實，在經由電噴霧與聚合程序後，IgG 蛋白質分子能夠存在於磁性複合殼核奈米粒子上。

In several years the cancer is the top ten of cause of death. Many studies in the biotechnology were focused on the development of the new technique to cure the cancers. In our laboratory, we integrate nanotechnology, molecular template and electrical spray technology to create a new chemical technique. This technique is to simplify processes in the conventional molecular template method. The concept is give nano-magnetic particles including target molecule, crosslinker, initiator, and functional monomer on the surface electricity by electrical spray method. The suspension of the particles fluidized in the quartz tube and collected after polymerize with functional monomers. The advantages of this method are to avoid nanoparticles aggregation and to get independent nano-magnetic balls wrapping organism molecules. It can be applied to detect the cancers by inter-force between molecules. By the action of the ac-dc magnetic field, the nano-magnetic particles generate rotation, vibration, and thermal energy to kill cancer cells. We can control the temperature at 42-43 °C by changing electromagnetic field to produce heat. The efficiency and performance of this heat-treatment is dependent on the type of the cancers and the properties of the nano-magnetic particles.
It is important to control the construction of the nanoparticles, particle size, surface groups, and the particle size distribution.
From experimental result, the morphology of liquid encapsulated magnetic nanoparticles at the exit of capillary change with increasing positive potential. The conductivity of sample is 90mS/cm and the range of applying positive potential is from 1500V to 4000V. The voltage of cone-jet mode is 3550V. The size distribution of magnetic core-shell composite nanoparticles is from 30nm to 90nm and the dispersibility of particles is good. In general, the size of molecularly imprinted polymer particles is at micrometer and the aggregation of particles is serious.Magnetic composite nanoparticles which are prepared by electrospray can improve the aggregation of molecularly imprinted polymer particles. From review paper, the range of particle size is from several to hundred micrometer during fluidization. In this research, the size of charge magnetic composite nanoparticles is below 100nm during fluidization from TEM result. So we can produce nanoparticles which are suspension in the fluidize bed by electrospray.
The fluorescence intensity of blank silicon wafer and magnetic composite core-shell nanoparticles are 0.0049 and 0.0872 a.u. . From the result, we can confirm that the existence of IgG after polymerization.

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