本研究提出一種材料，利用了生物相容性高、以及有良好光熱轉換效率的普魯士藍奈米粒子，將其本身表面的氰基 (CΞN) 利用還原劑氫化鋁鋰還原為胺基 (NH2)，使其可以用於將表面帶有羧酸根之氯化血紅素修飾於材料表面上。接著，由於氯化血紅素分子中的鐵離子與一氧化氮具有很高親和力，我們將一氧化氮氣體分子直接配位於氯化血紅素的鐵離子上，可以改善傳統的一氧化氮供體價格較高昂，且較不穩定、容易自發性的釋放一氧化氮的缺點。在合成出此可以攜帶一氧化氮之普魯士藍奈米粒子後，利用普魯士藍於近紅外光區域有吸收的特性，本實驗使材料經由808 nm雷射照射後有光熱轉換達到升溫的效果，可以控制一氧化氮的釋放。接著再利用一氧化氮於傷口區域有血管新生、幫助膠原蛋白合成等幫助加快傷口癒合功能，直接將材料滴至傷口區域進行一氧化氮的控制釋放，達到加快傷口癒合的功能。

We demonstrate a successful synthesis of Hemin-derivated Prussian Blue Nanoparticles and provide a nitric oxide controllable releasing platform. First, We synthesis the prussian blue nanoparticles, and reduce the surface cyano group into amine group by using Lithium aluminum hydride. Last, we modify Hemin on the Prussian blue surface, then conjugate the NO on the iron ion on Hemin because of the high affinity for nitric oxide to Hemin. Due to the Characteristics of he Prussian blue revealing NIR light-induced hyperthermia, this material can get control nitric oxide releasing under 808nm irradiation. As is well known that nitric oxide can be used for improving angiogenesis and increasing collagen synthesis, we combine 808 nm irradiation control releasing nitric oxide on the wound site to accelerate wound healing.

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