本研究利用良溶劑/非良溶劑法，製備β-環糊精的自組裝膠體。鈉離子的存在與β-環糊精上的極性羥基（-OH）有配位作用，進而促使其在離子交聯的影響下形成了柱狀的構造。當β-環糊精與戊二醛進行交聯反應，則會形成截然不同的雙螺旋構造，意味著戊二醛對β-環糊精擁有較佳的交聯特性，且雙螺旋構造通常須在掌性環境下才會形成。當氯化鈉及戊二醛同時存在時，反而導致鈉離子與氫氧基間的相互作用，抑制了戊二醛的交聯作用，使得自組裝β-環糊精間的交聯減少，並造成交聯不完全的構造。二異氰酸環己烷的高反應性，妨礙了高度規則性的自組裝β-環糊精交聯結構體的產生。針對如此合成的交聯β-環糊精與數種外消旋混合物所作的光學辨識性探討，所得結果顯示，β-環糊精所具有的掌性空腔，可能提供了光學辨識所需的掌性結合配位點，使其能夠辨別鏡像異構物，而達成光學分割的目的。

The self-assembly of supramolecular β-cyclodextrins was fabricated via good solvent/poor solvent method. The presence of sodium ions was expected to facilitate the formation of cross-linked columnar construction by coordinating with polar hydroxyl groups on β-cyclodextrin. When the self-assembled β-cyclodextrin was cross-linked by glutraldehyde, an interesting double helix construction was observed, indicating better cross-linking properties. However, the dual presence of sodium chloride and glutaraldehyde may cause unwanted interactions between sodium and hydroxyl groups leading to the inhibition of glutaraldehyde crosslinking, resulting in the reduction of β-cyclodextrin self-assembly crosslinking and incompletely crosslinked constructions. The high reactivity of diisocyanatohexane impeded the formation of highly ordered crosslinked construcstion of self-assembled β-cyclodextrin. The results of the optical resolution of various racemic mixtures with the synthesized cross-linked β-cyclodextrin reveal that the chiral cavities of the synthesized cross-linked β-cyclodextrin may serve some chiral binding sites for enantiomers distinguishing.

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