簡易檢索 / 詳目顯示

研究生: 劉春敏
Liu, Chun-Min
論文名稱: 台灣兒虐頭傷之流行病學研究
Epidemiology of pediatric abusive head trauma in Taiwan
指導教授: 呂宗學
Lu, Tsung-Hsueh
學位類別: 碩士
Master
系所名稱: 醫學院 - 公共衛生學系
Department of Public Health
論文出版年: 2021
畢業學年度: 109
語文別: 中文
論文頁數: 165
中文關鍵詞: 兒虐頭傷發生率流行病學國際疾病分類編碼
外文關鍵詞: Abusive head trauma, incidence, epidemiology, International Classification of Disease coding
相關次數: 點閱:72下載:17
分享至:
查詢本校圖書館目錄 查詢臺灣博碩士論文知識加值系統 勘誤回報
  • 背景:為了提高不同兒虐頭傷研究或監測的可比較性,美國疾病管制署於2012年集結專家訂出一套依照國際疾病分類編碼臨床修訂第九版編碼的非致命兒虐頭傷定義與依照國際疾病分類編碼第十版的致命兒虐頭傷定義。美國在2015年10月,台灣在2016年1月都改為臨床修訂第十版。可是,目前尚未有採用臨床修訂第十版非致命兒虐頭傷相關研究或監測。
    目的:首先探討兒虐頭傷臨床修訂第九版編碼轉譯為臨床修訂第十版的銜接度,接著比較使用這兩版進行兒虐頭傷發生率的流行病學輪廓是否有差異。
    方法:首先使用美國國立衛生統計中心公告的一般對應地圖探討美國疾管署臨床修訂第九版非致命兒虐頭傷定義改為臨床修訂第十版的對應差異。接著使用2010至2019年台灣全民健保門診與住院申報資料,依照前述定義分析出五歲以下兒虐頭傷的發生率與相關影響因素。本研究進一步使用醫令碼探討嚴重度,以及追蹤五年後神經功能預後及死亡情形。
    結果:在非致命兒虐頭傷狹義定義臨床修訂第十版比致命兒虐頭傷第十版多18個相關編碼,廣義定義多了14個編碼。使用申報資料估計發生率,僅針對住院個案,狹義與義定義個案數分別為362與392,後者比前者多了8%。如果加上急診申報資料,狹義與義定義個案數分別為480與533,後者比前者多了11%。不論是狹義定義或廣義定義,整體發生率年代趨勢差不多,但在2014年至2015年間,兒虐頭傷的人數有增加的現象。在年齡層方面,台灣兒虐頭傷個案以年齡為一歲以下者占最多數,其中又有超過一半以上個案其年齡為小於六個月。在性別方面,2015年前男性發生率大於女性發生率,但在2015年後則是女性多於男性。兒虐頭傷的死亡率約為15%,年齡越高死亡風險也越高。有將近一半的兒虐頭傷個案於追蹤期間會有發展遲緩的後遺症。
    結論:根據不同資料來源不同定義會估計出不同兒虐頭傷發生率,建議研究者應該都要呈現,讓相關決策者參考。建議未來還要針對上述定義與嚴重度的國際疾病編碼審定程序進行準確度研究。

    Background: To improve the comparability of different studies on pediatric abusive head trauma (AHT), the Centers for Disease Control and Prevention(CDC) in the United States developed an International Classification of Diseases (ICD) coding algorithm for non-fatal AHT based on Ninth Revision Clinical Modification (ICD-9-CM) and for fatal AHT based on Tenth Revision (ICD-10) in 2012. The Tenth Revision Clinical Revision (ICD-10-CM) was introduced in October, 2015 in the United States and January, 2016 in Taiwan. However, no AHT study used ICD-10-CM definition for non-fatal AHT was performed. Objective: We sought in this study to develop an CDC ICD-10-CM version for non-fatal AHT and to delineate the epidemiological profile of HAT in Taiwan from 2010 through 2019. Methods: We firstly used general equivalence mappings developed by the US National Center for Health Statistics to determine the ICD-10-CM version of CDC non-fatal AHT definitions. We then used Taiwan National Health Insurance outpatients and inpatients claims data for years 2010 through 2019 to estimate the incidence of non-fatal AHT according to the two versions of definitions. Thirdly, we used treatment codes in claims data to proxy measure the severity of non-fatal AHT and five year logn-term neurological deficit outcomes. Results: The number of AHT based on inpatients claims data according to narrow and broad definition was 362 and 392, respectively, an 8% more cases. If we based both emergency visits and inpatients claims the number of AHT was 480 and 533, respectively, an 11% more cases. The pattern of incidence trends were similar according to two definitions; however, an increase of incidence was note during 2014-2015. More than half of the AHT cases were younger than six months. Before 2015, the incidence among boys was higher than girls; however, inversed after 2016. The estimated mortality among AHT was 15% and increased with age. More thant half of the cases had sequelae of development delay during the follow-up period. Conclusions: Incidence of AHT varied according to different definitions and based on different data sources, we suggested that researchers should reveal the whole picture for stakeholders. Further validity studies on ICD coding algorithms of different definitions and proxy measures of severity are needed.

    中文摘要 I 英文摘要 III 誌謝 VI 表目錄 IX 圖目錄 X 附錄 XI 第壹章 前言 1 第一節 研究背景 1 第二節 知識缺口 3 第三節 研究目的 3 第貳章 文獻探討 5 第一節 兒虐頭傷常見臨床症狀及診斷處置 5 第二節 兒虐頭傷定義 8 第三節 應用美國CDC兒虐頭傷定義的流行病學研究 14 第四節 兒虐頭傷預後的相關研究 21 第五節 國際疾病分類第九版與第十版的差異 26 第參章 研究設計 28 第一節 資料來源 28 第二節 研究變項定義 30 第三節 研究設計與分析流程 32 第肆章 研究結果 35 第一節 含國際疾病分類第十版的兒虐頭傷編碼整理 35 第二節 美國CDC四種定義下兒虐頭傷人口學差異 37 第三節 兒虐頭傷的年代發生率趨勢 40 第四節 狹義確定的兒虐頭傷個案,其神經功能預後及死亡情形 42 第伍章 討論 44 第一節 美國CDC兒虐頭傷四種定義的差異 44 第二節 兒虐頭傷的年代發生率趨勢結果與過去研究討論 45 第三節 狹義確定的兒虐頭傷個案,其神經功能預後及死亡情形 46 第四節 研究強項與限制 47 第五節 結論 49 第陸章 參考文獻 50

    Barlow KM, Thomson E, Johnson D, Minns RA. Late neurologic and
    Cognitive sequelae of inflicted traumatic brain injury in infancy. Pediatrics, 116(2):e174-e185, 2005.
    Boop S, Axente M, Weatherford B, Klimo P. Abusive head trauma: an
    epidemiological and cost analysis. J Neurosurg Pediatr, 18(5):542-549, 2016.
    Barell V, Aharonson-Daniel L, Fingerhut LA, Mackenzie EJ et al. An
    introduction to the Barell body region by nature of injury diagnosis matrix. Inj
    Prev, 8(2):91-96, 2002.
    Berger RP, Fromkin JB, Stutz H, Makoroff K et al. Abusive head trauma during a time of increased unemployment: a multicenter analysis. Pediatrics, 128(4):637-643, 2011.
    Christian CW, Block R. Abusive head trauma in infants and children.
    Pediatrics, 123(5):1409-1411, 2009.
    Chevignard MP, Lind K. Long-term outcome of abusive head trauma. Pediatr
    Radiol, 44(4):548-558, 2014.
    Chang YT, Chang HY, Chen LW, Lu TH et al. Incidence and characteristics of
    paediatric abusive head trauma in Taiwan, 2006–2015: a nationwide population-
    based study. Inj Prev, 1-7, 2020.
    Duhaime AC, Christian C, Moss E, Seidl T. Long-term outcome in infants with the shaking-impact syndrome. J Neurosurg Pediatr, 24(6):292-298, 1996.
    Elinder G, Eriksson A, Hallberg B, Lynoe N et al. Traumatic shaking: The role of the triad in medical investigations of suspected traumatic shaking. Acta Paediatr, 107:3-23, 2018.
    Herman BE, Makoroff KL, Corneli HM. Abusive head trauma. Pediatr Emerg
    Care, 27(1):65-69, 2011.
    Huang MI, O'Riordan MA, Fitzenrider E, McDavid L, Cohen AR, Robinson S. Increased incidence of nonaccidental head trauma in infants associated with the economic recession. J Neurosurg Pediatr, 8(2):171-176, 2011.
    Hung KL. Pediatric abusive head trauma. Biomed J, 43(3):240-250, 2020.
    King WJ, MacKay M, Sirnick A. Shaken baby syndrome in Canada: clinical
    characteristics and outcomes of hospital cases. CMAJ, 168(2):155-159, 2003.
    Kemp AM. Abusive head trauma: recognition and the essential investigation.
    Arch Dis Child, 96(6):202-208, 2011.
    Kochanek PM, Tasker RC, Carney N, Totten AM et al. Guidelines for the management of pediatric severe traumatic brain injury: update of the brain trauma foundation guidelines. Pediatr Crit Care Med, 20(3S):S1-S82, 2019.
    Lopes NR, Eisenstein E, Williams LC. Abusive head trauma in children: a
    literature review. An Pediatr, 89(5):426-433, 2013.
    Lind K, Toure H, Brugel D, Meyer P, Laurent-Vannier A, Chevignard M.
    Extended follow-up of neurological, cognitive, behavioral and academic outcomes after severe abusive head trauma. Child Abuse Negl, 51:358-367, 2016.
    Letson MM, Cooper JN, Deans KJ, Scribano PV, Makoroff KL, Feldman KW, Berger RP. Prior opportunities to identify abuse in children with abusive head trauma. Child Abuse Negl, 60:36-45, 2016.
    Matschke J, Herrmann B, Sperhake J, Körber F, Bajanowski T, Glatzel M.
    Shaken baby syndrome: a common variant of non-accidental head injury in infants. Dtsch Arztebl Int, 106(13):211-217, 2009.
    Niederkrotenthaler T, Xu L, Parks SE, Sugerman DE. Descriptive factors of
    abusive head trauma in young children—United States, 2000–2009. Child Abuse
    Negl, 37(7):446-455, 2013.
    Nadarasa J, Deck C, Meyer F, Willinger R, Raul JS. Update on injury
    mechanisms in abusive head trauma-shaken baby syndrome. Pediatr Radiol, 44(4): 565-570, 2014.
    Nuño M, Pelissier L, Varshneya K, Adamo MA, Drazin D. Outcomes and
    factors associated with infant abusive head trauma in the US. J Neurosurg
    Pediatr, 16(5):515-522, 2015.
    Nuño M, Ugiliweneza B, Zepeda V, Anderson JE, Coulter K, Magana JN,
    Boakye M. Long-term impact of abusive head trauma in young children. Child
    Abuse Negl, 85:39-46, 2018.
    Nuño M, Ugiliweneza B, Bardini RL, Ozturk A, Stephenson JT, Magaña JN.
    Age-related mortality in abusive head trauma. J Trauma Acute Care Surg, 87(4):
    827-835, 2019.
    Nuño M, Shelley CD, Ugiliweneza B, Schmidt AJ,Magana JN. Differences in
    incidence and case fatality of abusive head trauma. Child Abuse Negl, 104:1-10,
    2020.
    Parks S, Sugerman D, Xu L, Coronado V. Characteristics of non-fatal abusive
    head trauma among children in the USA, 2003–2008: application of the CDC operational case definition to national hospital inpatient data. Inj Prev, 18(6):392-398, 2012.
    Parks SE, Kegler SR, Annest JL, Mercy JA. Characteristics of fatal abusive head
    trauma among children in the USA: 2003–2007: an application of the CDC
    operational case definition to national vital statistics data. Inj Prev, 18(3):193-199, 2012.
    Parks SE, Annest JL, Hill H A, Karch DL. Pediatric abusive head trauma:
    recommended definitions for public health surveillance and research, 2012.
    Shein SL, Bell MJ, Kochanek PM, Tyler-Kabara EC et al. Risk factors for mortality in children with abusive head trauma. J Pediatr, 161(4):716-722, 2012.
    Shanahan ME, Zolotor AJ, Parrish JW, Barr RG, Runyan DK. National, regional, and state abusive head trauma: application of the CDC algorithm.
    Pediatrics, 132(6):e1546-e1553, 2013.
    Stewart CL, Holscher CM, Moore EE, Bronsert M, Moulton SL, Partrick DA,
    Bensard DD. Base deficit correlates with mortality in pediatric abusive head
    trauma. J Pediatr Surg, 48(10):2106-2111, 2013.
    Sieswerda‐Hoogendoorn T, Bilo RA, Duurling LL, Karst WA, Maaskant JM,
    Aalderen WM, Rijn RR. Abusive head trauma in young children in the Netherlands:evidence for multiple incidents of abuse. Acta Paediatr, 102(11):e497-e501, 2013.
    Scribano PV, Makoroff KL, Feldman KW, Berger RP. Association of perpetrator relationship to abusive head trauma clinical outcomes. Child Abuse Negl, 37(10):771-777, 2013.
    Selassie AW, Borg K, Busch C, Russell WS. Abusive head trauma in young children: a population-based study. Pediatr Emerg Care, 29(3):283-291, 2013.
    Shaahinfar A, Whitelaw KD, Mansour KM. Update on abusive head trauma. Curr Opin Pediatr, 27(3):308-314, 2015.
    Talvik I, Männamaa M, Jüri P, Leito K et al. Outcome of infants with inflicted
    traumatic brain injury (shaken baby syndrome) in Estonia. Acta Paediatr, 96(8):1164-1168, 2007.
    Vinchon M, Defoort-Dhellemmes S, Desurmont M, Dhellemmes P. Accidental
    and nonaccidental head injuries in infants: a prospective study. J Neurosurg Pediatr, 102(4):380-384, 2005.
    Yamaoka Y, Fujiwara T, Fujino Y, Matsuda S, Fushimi K. Incidence and age
    distribution of hospitalized presumptive and possible abusive head trauma of
    children under 12 months old in Japan. J Epidemiol Community Health, 30(2):91-97, 2020.
    王健興、黃俊雄、陳昭文、張晏晏與呂宗學(2017)。急診科與外傷科醫師應該知道的ICD-10-CM修訂理念。臺灣醫界,60(3),15-20。
    內政部戶政司全球資訊網 (2021)。歷年全國人口統計資料-04年中人口按性別及五齡組。取自https://www.ris.gov.tw/app/portal/346
    衛生福利部中央健康保險署 (2021)。ICD-9-CM2001年版與ICD-10-CM對應資料檔。取自https://www.nhi.gov.tw/Content_List.aspx?n=467C56886B6E9081&topn=23C660CAACAA159D

    下載圖示 校內:立即公開
    校外:立即公開
    QR CODE