血液氧合濃度是一項重要的生理指標，也廣泛的應用在臨床上。本篇文章係利用反射式頻域光子遷移系統(Frequency Doman Photon Migration, FDPM)來監測手指動脈血氧飽和濃度(SaO2)與組織血氧飽和濃度(StO2)，另一方面我們參考運動生理學的理論，監測運動中肌肉組織血氧飽和度的變化，以提供運動員更多的生理資訊做為訓練的參考；漫反射光譜學以輻射傳播方程式(Radiative transport equation, RTE)為基礎，對組織的特性做適當的簡化為擴散理論(Diffusion theory)，透過擴散理論可計算出在特定光學參數下光子行走的相位及振幅的衰減；研究中利用660nm、780nm與830nm三個波長的雷射二極體，分別調變100MHz、140MHz及180MHz。雷射二極體經過振幅調變過後會產生一個光子密度波(Photon Density Wave, PDW)，在組織中訊號會產生振幅衰減及相位偏差，再透過疊代及最小平方法求出吸收及縮減散射，最後再利用色團擬合的方法計算出帶氧血紅素(HbO2)及不帶氧血紅素(Hb)的濃度，可利用2.2.2章中的介紹計算出StO2及SaO2；本研究將其針對手指的動脈血氧、組織血氧、總血紅素，以及運動的肌肉組織血氧監控進行探討，手指血氧我們與市售儀器比較，由於FDPM系統對於壓力的變化相當敏感，因此我們會同步對壓力進行監控；運動實驗則是參考哈佛醫學院對於運動中工作肌群的血氧濃度變化的研究，採漸增式運動強度測試的方法，監測漸增式運動強度測試時的肌肉組織血氧濃度(SmO2)與非運動肌肉組織血氧濃度(StO2)的變化趨勢，觀察系統量測出的StO2是否符合運動生理學中所描述，並且以Humon作為實驗的參考標準。本實驗因為需要長時間的監控StO2的變化，所以穩定性的量測是至關重要的，穩定性量測30分鐘的振幅異變數為0.12%至0.28%之間，相位標準差為0.034o至0.16o，說明這樣的系統穩定性是在合理的範圍之內。

Blood oxygen saturation is a very important physiological parameter. In this study, a Frequency-Domain Photon Migration system(FDPM) in diffuse reflectance spectroscopy was used to measure the tissue optics Parameters (absorption and reduced scattering coefficient) with laser diodes at 660 nm, 780 nm, and 830 nm, and the spectral fitting method, to fit the concentration of oxy-hemoglobin and deoxy-hemoglobin, calculate the arterial oxygen saturation and tissue oxygen saturation according to the ratio and dynamic information of each other, The commercially available arterial oximeter is used as a reference for the measurement. The experimental results are consistent with the results of the commercially available arterial oximeter, which verifies the feasibility of the system measurement and improves the traditional finger clip arterial oximeter. Measure the limitation of location, and apply it to the measurement of not-working muscle oxygen saturation, cooperate with Humon to measure the tissue oxygen saturation of muscle tissue of working muscle groups during exercise, and analyze the physiological theory of exercise on muscle tissue blood in different periods The effect of tissue hemodynamics on the experimental results is also consistent with theoretical predictions.

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