在本研究中，先將陰離子型界面活性劑十二烷基硫酸鈉（sodium dodecylsulfate, SDS）與陽離子型界面活性劑十六烷基三甲基溴化銨（hexadecyltrimethyl　ammonium bromide, HTMAB）的水溶液混合，以形成離子對雙親分子（ion pair amphiphile, IPA）HTMA-DS的沈澱物，再由HTMA-DS與HTMAB，以強制的方式形成帶正電的陰陽離子液胞（catanionic vesicle）。並選擇高濃度HTMA-DS/HTMAB = 4 mM/2 mM及低濃度HTMA-DS/HTMAB = 0.2 mM/0.6 mM的混合系統，添加不同莫耳比率的正十六碳醇或正十八碳醇，以探討長碳鏈醇類對陰陽離子液胞物理穩定性的影響。
　　粒徑分析結果顯示，於低濃度HTMA-DS/HTMAB混合系統中添加正十六碳醇或正十八碳醇，均可提升陰陽離子液胞的物理穩定性，而添加正十八碳醇的效果較佳。若於高濃度HTMA-DS/HTMAB混合系統中添加正十六碳醇或少量的正十八碳醇，則反而使液胞的穩定性變差。而添加3～5 mM的正十八碳醇，就可製備出較穩定的液胞分散液。然而添加正十六碳醇或正十八碳醇促進液胞物理穩定性的效果，都比不上添加膽固醇的效果顯著。界面電位的量測結果顯示，於高濃度或低濃度的HTMA-DS/HTMAB混合系統中添加正十六碳醇或正十八碳醇，皆可製備出帶正電的液胞。在低濃度混合系統中，於大部分的情況下則會同時出現帶負電的訊號，所占的強度則大都小於10%。由於無法僅由液胞的界面電位說明其物理穩定性，因此液胞雙層膜內的組成及排列對液胞的物理穩定性應具有很大的影響。此外，利用熱掃描卡量計法（differential scanning calorimetry, DSC）量測液胞雙層膜結構的相轉移溫度，發現添加正十八碳醇於高濃度HTMA-DS/HTMAB混合系統所形成的液胞，其相轉移溫度較高，這可能與液胞雙層膜分子間的作用力增加有關。

　　In this study, the ion pair amphiphile (IPA), HTMA-DS, was obtained as precipitate first by mixing aqueous solutions of the anionic surfactant, sodium dodecylsulfate (SDS), and the cationic surfactant, hexadecyltrimethylammonium bromide (HTMAB). The IPA and HTMAB were then used to form positively charged catanionic vesicles by a forced approach. N-hexadecanol or n-octadecanol was added with various molar ratios in the high concentration HTMA-DS/HTMAB = 4 mM/2 mM and low concentration HTMA-DS/HTMAB = 0.2 mM/0.6 mM systems, in order to investigate the effects of long-chain alcohols on the physical stability of catanionic vesicles.
　　Particle size analyses indicated that with the addition of n-hexadecanol or n-octadecanol in the low concentration HTMA-DS/HTMAB system, the physical stability of catanionic vesicles was enhanced, especially for the presence of n-octadecanol. When n-hexadecanol or low molar ratios of n-octadecanol were present in the high concentration HTMA-DS/HTMAB system, the vesicle stability became lower. By adding 3～5 mM n-octadecanol, then more stable vesicle dispersions could be prepared. However, the effect of n-hexadecanol or n-octadecanol on promoting the vesicle stability is less significant than that of cholesterol. Zeta potential measurements showed that positively charged vesicles could be obtained by adding n-hexadecanol or n-octadecanol in the low or high concentration HTMA-DS/HTMAB system. For the low concentration system, a negative charge signal was also detected in most cases but with the intensity always less than 10%. Since the physical stability of the vesicles could not be explained only by zeta potential data, the bilayer composition and packing of the vesicles appeared to have a strong influence on the vesicle stability. Moreover, differential scanning calorimetry (DSC) was applied to measure the phase transition temperature of the vesicle bilayer structure. A higher phase transition temperature was found for the vesicles prepared by adding n-octadecanol in the high concentration HTMA-DS/HTMAB system, which might be related to the enhanced molecular interactions in the vesicle bilayers.

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