隨著人口老化，失智症患者不斷增加。網路提供的保健知識越來越多，但準確性令人存疑。使用者在網路上彼此分享外顯知識，稱為“systemizing ba”（知識創造過程中的組合階段）。從各來源獲得的不準確知識可能導致知識創造過程的謬誤，因此探討影響醫療保健知識創造過程的因素是非常重要的。
本研究的目的是探討來自合法研究機構的不準確知識是如何影響個人情緒和信任程度的。過去的研究已經討論過網站品質對使用者情緒的影響，卻沒有研究具體探討知識準確性的影響，因此本研究將信息準確性作為刺激來擴展S-O-R（刺激 - 生物 - 反應）理論，利用fMRI（功能性磁共振成像）獲得接收者的行為資料，並觀察大腦中掌管情緒/知覺信任以及決策相關的區域。
研究結果顯示，當知識水平較高的人接收來自合法機構的不準確知識會有較大的情緒以及較低的信任反應，且功能影像結果顯示腦島、前扣帶迴皮質（ACC）、內側前額葉皮質（mPFC）有被激化，而在正確知識的情況下，則是前額回和背內側前額葉皮質（dmPFC）呈現激化狀態。

With the aging population, the number of patients with dementia is increasing. Providing healthcare to dementia patients requires caregivers to have relevant knowledge, and thus, the Internet is becoming an increasingly useful source of health information. However, online healthcare information can be obtained through various providers, and its accuracy is difficult to determine, thus raising the trustworthiness issues toward healthcare information providers or platforms. In the online health information context, peoples are engaged in sharing explicit knowledge with each other in the virtual world, which represents “systemizing ba” (a combination phase in the knowledge creation process). Inaccurate information/knowledge obtained from different sources may lead to fallacies in the knowledge creation process. Therefore, it is important to discuss factors influencing the knowledge creation process in healthcare. The purpose of this study is to explore how declarative type explicit knowledge obtained from healthcare websites/platforms may affect personal emotion and trust levels when some of the informational content is found to be inaccurate, specifically when the sources of information are from legitimate institutes or professional groups. Past research has discussed the impact of website quality on viewers’ emotions. However, no study has to date specifically considered the impact of information accuracy. Therefore, this study extends the S-O-R (Stimulus-Organism-Response) theory by including information accuracy as stimuli with the intention to observe knowledge receivers’ emotional state/trust perceptions and decisions. This study uses fMRI (functional Magnetic Resonance Imaging) technology to obtain behavioral data from information receivers and to observe specific brain areas related to emotion/trust perceptions and decision making. The results of this study indicated that information receivers who have a higher level of prior knowledge will have a significant emotional reaction and much lower trust level when viewing inaccurate information, especially when the source of the informational content is a legitimate institute. The functional imaging data revealed activation of the insula, anterior cingulate cortex (ACC), and medial prefrontal cortex (mPFC) under such conditions. In addition, the results indicated activation in the frontal gyrus and dorsomedial prefrontal cortex (dmPFC) in situations where the information was accurate.

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