本研究使用X光激發之Ce摻雜的LiYF4閃爍體奈米粒子，並於材料表面修飾一氧化碳釋放分子—CORM-401。在受到X光激發後LiYF4閃爍體奈米粒子產生紫外光波段的放光，此放光可使修飾於材料表面之一氧化碳釋放分子中心金屬錳與一氧化碳斷鍵，並釋放一氧化碳氣體，所釋放之一氧化碳具有氣體治療之作用。且因實驗使用的激發光源為X射線，其本來就是治療癌症的重要手段之一，因此本研究亦可使用X光作癌症的放射治療。另外，CORM-401分子中的中心金屬錳，於釋放一氧化碳後會產生由正一價變為正二價的價數改變，此價數的改變可應用於核磁共振顯影上。因此本實驗中設計之奈米粒子可同時具有放射治療、一氧化碳治療以及核磁共振顯影的作用。

In our study, we used Ce-doped LiYF4 scintillator nanoparticle, which emits UV light after being excited by X-ray. In addition, carbon monoxide (CO) causes mitochondrial dysfunction and induces apoptosis of cancer cells, which can be used as a means of treating tumors. Therefore, we modified CORM-401 outside of the nanoparticles, and the UV light emitted by X-ray irradiation of nanoparticles can release CO molecules from CORM-401, which can be used for the treatment of deep tumors. Moreover, after CORM-401 releases CO molecules, Mn2 + on the molecules can enhance MRI imaging. Multifunctional nanomaterials in this study can achieve deep tumor treatment and MRI imaging.

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