我們可以由高選擇性的3-MCR反應來製備α‚α'–iminodiacetic acid的不對稱異構物，它合成的方法是將異腈、醛類和纯的L–氨基酸在甲醇當溶劑下反應，所得到不對稱異構物的絕對組態，是由合成過程中的氨基酸所決定。

　　將合成出來的產物再進行一連串衍生化反應，包括在氮上甲基化、還原酯基和醯胺以及將酯基醯胺化。

　　我們希望能利用這些衍生出來的不對稱配位基進行催化不對稱合成。

　Several pairs of enantiomeric α‚α'–iminodiacetic acid analogues were prepared by highly diastereoslective 3-MCR(multicomponent reaction),which involves a reaction of an isocyanide,an aldehyde,and an enantiomerically pure amino acid in methanol.Synthesis of each of the enantiomer was controlled by the configuration of the amino acid.

　Derivatives of the optically pure chiral ligands were prepared by methylation at nitrogen,reduction of ester and amide group,and conversion of ester into amide.

　We hope to use these chiral ligands to undergo catalytic asymmetric synthesis.

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