多氯戴奧辛/口夫喃(polychlorinated dibenzo-p-dioxins/ dibenzofurans, PCDD/Fs)為環境荷爾蒙之一，具備在環境中不易生物或非生物分解之特性，而且由於PCDD/Fs為親脂性化合物，極易透過食物鏈蓄積於動物或人體之脂肪組織。在生態環境中，生物間之關係性以食物鏈最為明顯，人類是位於生態系食物鏈的最高階層，因此人體中化學物質的累積量會相對增加，故欲瞭解PCDD/Fs對人體風險危害時進行生態系中不同階層之累積放大時，經由食物鏈進行PCDD/Fs之生物濃縮與生物放大研究日益重要。
　　本研究以受到PCDD/Fs高度污染水域為對象，分析底泥及食物鏈中之各種生物體內17種PCDD/Fs同源物之含量與分布，進而探討不同階級消費者之間PCDD/Fs之生物放大、生物累積之特性。在戴奧辛污染水域選取，本研究以台鹼安順廠區旁之海水貯存池為對象，採集水域中環境樣本（9個底泥），水生物樣本包括蝦(6隻草蝦)、蟹(14隻短槳蟳、紅腳蟳及遠海梭子蟹)和魚體(吳郭魚、虱目魚、大鱗鯔、環球海鰶共100隻)，鳥類樣本(小白鷺4隻和夜鷺3隻)，樣本經前處理後，以高解析氣相層析儀/高解析質譜儀(HRGC/HRMS)分析17種2,3,7,8-取代之PCDD/Fs同源物，進而探討PCDD/Fs透過食物鏈在各階層之生物濃縮及生物放大之特性。
　　研究結果顯示，底泥樣本之PCDD/Fs平均濃度為511,418（89,002~2,298,348）pg/g，在同源物分布上，以,2,3,4,6,7,8-HpCDF、1,2,3,4,6,7,8-HpCDD、OCDF及OCDD為主要同源物，總計佔98.9％，與過去文獻比較，顯示與受PCP污染土壤中PCDD/Fs同源物分布非常類似。生物樣本中PCDD/Fs原始濃度高低順序為蝦子＞螃蟹＞環球海鰶＞虱目魚＞吳郭魚＞大鱗鯔（80,559～5,260 pg/g lipid）。研究顯示生活習性靠近底泥之生物，如蝦蟹其體內所累積PCDD/Fs濃度較高，尤其在高氯數同源物含量比魚體高出甚多。此外，魚體中肝臟PCDD/Fs濃度比魚肉濃度高。水生物之PCDD/Fs總毒性當量濃度範圍為15.7～123 pg WHO -TEQ/g sample高於歐盟規範濃度（4 pg WHO-TEQ/g sample）約4-38倍。主要毒性當量貢獻來自2,3,4,7,8, -PeCDF與1,2,3,7,8,-PeCDD（蝦蟹：55.7％、魚體：64.8％）。小白鷺及夜鷺PCDD/Fs平均濃度為1519（114~3755） pg/g，夜鷺體內PCDD/Fs濃度高於小白鷺。
　　在PCDD/Fs之生物濃縮特性方面，以蝦蟹所含PCDD/Fs所計算之平均生物濃縮係數（Bioconcentration factor, BCF）為148,238（lipid base）及3,783 （sample base）；四種魚魚體平均BCF為58,657（lipid base）、3,479（sample base），顯示此污染水域之生物具明顯之PCDD/Fs生物濃縮特性。其中蝦蟹之BCF高於魚體，此差異與物種棲息特性，攝食方式及PCDD/Fs代謝能力有關。數據顯示BCF隨著PCDD/Fs含氯數增加而有下降之情形。而水生物間之生物放大特性，僅在僅2,3,7,8-TCDD、1,2,3,7,8-PeCDD和1,2,3,6,7,8-HxCDF之BMF＞1，具有生物放大特性，然而多數同源物無生物放大特性，其原因在魚與蝦蟹間，因所採魚體及蝦蟹均屬較大體型，其營養階層相關性較差所致：至於小白鷺、夜鷺與魚體間，可能與小白鷺、夜鷺均為幼鳥，累積濃縮時間較短及其與大型魚體之營養階層相關性較差有關。探討底泥-水生物累積係數，蝦蟹PCDD/Fs之BSAF 值0.0003～0.2698；魚體魚肉之BSAF值0.00002～0.1009；魚體肝臟之BSAF值0.0003～0.2687。BSAF值在水生物中高低依序：蝦蟹＞魚體肝臟＞魚體魚肉。數據顯示，BSAF亦依循著PCDD/Fs同源物含氯數增加而遞減之現象，此現象與PCDD/Fs同源物之分子大小（PCDD/Fs含氯數愈高其分子越大，不易被生物體所利用）及PCDD/Fs溶解度（PCDD/Fs含氯數愈高，水中溶解度愈低，底泥中濃度愈高）有關。

　　Polychlorinated dibenzo-p-dioxins/dibenzofurans (PCDD/Fs)are kind of environmental hormones。Due to these lipophilic nature chemicals are high potential for accumulation in biological lipid tissue. In the environment, PCDD/Fs will accumulate in animals or human body through the food chain. Human is the top-level consumers in the food web, in order to evaluate the potential risk of PCDD/Fs to humans, it is important to understand the level and characteristics of bioconcentration and biomagnification of PCDD/Fs in the aquatic food web.The aim of this study is to investigate the level and distributions of the PCDD/Fs in sediment, aquatic biota and bird from PCP contaminate area. This study also aimed to provide information on the bioconcentration, biomagnification factors for PCDD/Fs. The samples includes sediments, grass prawn (Penaeus monodon), crab (Portunus pelagicus), Thalamita crenata, Scylla olivacea ), fish (Oreochromis mossambicus, Chanos chanos, Liza macrolepis, Nematolosa come) and bird (Nycticorax nycticorax, Egretta garzett ) were collected from the sea reservoir located near the deserted factory. All samples were after the extraction and cleanup procedures, the quantification of 2,3,7,8-substituted PCDD/Fs is performed with HRGC/HRMS.The concentration of total PCDD/Fs in sediment was 511,418（89,002~2,298,348）pg/g, and 1,2,3,4,6,7,8-HpCDF、1,2,3,4,6,7,8- HpCDD、OCDD and OCDF are the predominant congeners of PCDD/Fs about （98.9％）. According the references, the congener profile is very similar then that in the PCP contaminated area. The concentration of aquatic biota is grass prawn＞crab＞Hairback herring＞Salmon herring＞Tilapia＞Big scale liza（80559～5259.7pg/g lipid）. The concentration of PCDD/Fs was found to be higher in the liver tissues of fish than those in muscle tissues. The concentration of PCDD/Fs-TEQ in aquatic biota is 15.7～123 pg WHO-TEQ/g sample which is high than EU（4pg WHO-TEQ/g sample）4-38 fold and the main congeners contribution are 2,3,4,7,8,-PeCDF and 1,2,3,7,8,-PeCDD（shellfish：55.7％、fish：64.8％）。Therefore, the concentration of PCDD/Fs of bird is 1519（114~3755）pg/g lipid, and the concentration of PCDD/Fs in Black-crowned Night Heron is high than Little Egre.
　　Furthermore, BCF were estimated the shellfish is 148238（lipid base）、3783（sample base）, in fish is 58657（lipid base）、3479（sample base）.BMF were estimated from fish to shellfish and bird to fish. The BMF value were estimated higher than 1 in 2,3,7,8-TCDD、1,2,3,7,8-PeCDD and 1,2,3,6,7,8 -HxCDF and there are no biomagnification on other congeners. The reason might be due to the tropic position. The average BSAFs were estimated and range from 0.0003～0.2698 and 0.00002～0.1009 and 0.0003～0.2687 for shellfish, muscle of fish and liver of fish. In the meantime, the BSAF value tended to decrease as the number of chlorines increased on both groups of PCDD and PCDF compound. This might be due to the water solubility of PCDD/Fs and the molercular cross-sectional size of PCDD/Fs.

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