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研究生：	莊惠中 Zhuang, Hui-Zhong
論文名稱：	原位法製備具協同抗菌效果之銀/氧化鋅複合明膠奈米膠 Gelatin composite nanogels comprised of in-situ formed zinc oxide and silver nanoparticles with synergistic effect on antibacterial activity
指導教授：	詹正雄 Jan, Jeng-Shiung
學位類別：	碩士 Master
系所名稱：	工學院 - 化學工程學系 Department of Chemical Engineering
論文出版年：	2023
畢業學年度：	111
語文別：	中文
論文頁數：	89
中文關鍵詞：	抗菌、酵素降解、協同抗菌效果、增強抗菌效果、銀奈米粒子、氧化鋅奈米粒子、複合奈米凝膠粒子、原位形成法、線蟲
外文關鍵詞：	Antibacterial activity, enzymatic degradation, gel particle, gelatin, silver, zinc oxide, in-situ formation, nanoparticle, nematode
相關次數：	點閱：67 下載：0
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摘要	I
Extended Abstract	II
誌謝	XIV
目錄	XV
表目錄	XIX
圖目錄	XX
第一章 緒論	1
1 - 1 前言	1
1-1-1 多重抗藥性細菌	1
1-1-2 奈米抗菌技術	2
1-1-3 生醫材料	3
1 - 2 研究動機	4
第二章 文獻回顧	6
2 – 1無機抗菌材料	6
2-1-1銀奈米粒子	6
2-1-2氧化鋅奈米粒子	9
2-1-3銀和氧化鋅奈米粒子毒性探討	10
2 – 2明膠	12
2 – 3奈米凝膠粒子	14
2-3-1 奈米凝膠粒子之定義	14
2-3-2 化學交聯	15
2-3-3 物理交聯	17
2 – 4不同的複合奈米凝膠粒子抗菌應用	20
2-4-1 載有抗菌劑的奈米凝膠粒子	20
2-4-2 載銀奈米凝膠粒子	21
2-4-3 抗菌奈米凝膠粒子表面塗層應用	22
2 – 5 實驗細菌與線蟲介紹	24
2-5-1 金黃色葡萄球菌(S. aureus)	24
2-5-2 志賀桿菌(Shigella flexneri)	25
2-5-3出血性大腸桿菌(Enterohemorrhagic Escherichia coli , EHEC)	26
2-5-4 沙門氏桿菌(S. typhimurium)	26
2-5-5 秀麗隱桿線蟲(C. elegans)	27
第三章 實驗方法	29
3 - 1 實驗藥品與儀器設備	29
3 - 2 實驗細胞、菌株和線蟲	32
3 - 3高分子合成	33
3 - 4奈米凝膠粒子製備	34
3 - 5 以原位形成法製備銀與氧化鋅奈米粒子複合奈米凝膠粒子	35
3 - 6 生物相容性測試	36
3-6-1 細胞凍存與解凍	36
3-6-2 細胞繼代培養	36
3-6-3 細胞計數	37
3-6-4 細胞毒性測試	37
3-6-5 溶血性測試	38
3-6-6紅血球與細菌、高分子共培養實驗	38
3 – 7奈米凝膠粒子抗菌實驗	40
3-7-1 製備瓊脂培養基	40
3-7-2 培養菌盤與菌液	40
3-7-3 定量菌液	40
3-7-4 細菌塗盤與計算菌落數	41
3-7-5 SEM分析用的細菌樣本製備	41
3 - 8 動物實驗	42
3-8-1 C. elegans 品系及培養	42
3-8-2 線蟲定量及同步化	42
3-8-3 線蟲存活率	43
3 - 9實驗儀器之分析原理	44
3-9-1 核磁共振光譜 (Nuclear Magnetic Resonance Spectroscopy, NMR)	44
3-9-2 動態光散射儀分析儀 (Dynamic Light Scattering, DLS)	44
3-9-3 紫外光/可見光光譜儀(UV/Vis spectrophotometer)	46
3-9-4 穿透式電子顯微鏡 (Transmission Electron Microscope, TEM)	47
3-9-5 傅利葉轉換紅外線光譜儀 (Fourier-transform infrared spectroscopy, FT-IR)	48
3-9-6 高解析感應耦合電漿質譜分析儀 (Inductively Coupled Plasma-Mass Spectrometer, ICP-MS)	49
3-9-7 掃描式電子顯微鏡 (Scanning Electron Microscope, SEM)	51
第四章 結果與討論	52
4 - 1 高分子合成結構分析	52
4-1-1 明膠與改質明膠結構鑑定	52
4 - 2複合奈米凝膠粒子性質分析	53
4-2-1 複合奈米凝膠粒子之粒徑與界達電位分析	53
4-2-2 複合奈米凝膠粒子之UV-Vis 和FT-IR光譜分析	56
4-2-3複合奈米凝膠粒子之金屬元素定量分析	58
4-2-4複合奈米凝膠粒子TEM分析	60
4 – 3 奈米凝膠粒子之生物相容性分析	62
4-3-1 溶血性試驗分析	62
4-3-2 細胞毒性分析	64
4 – 4奈米凝膠粒子抗菌能力之探討	66
4-4-1 複合奈米凝膠粒子MIC與MBC分析	66
4-4-2 複合奈米凝膠粒子之抗菌SEM圖與機制探討	72
4-4-3 複合奈米凝膠粒子之細菌生長抑制曲線分析	74
4 – 5奈米凝膠粒子動物實驗應用探討	75
4-5-1 秀麗隱桿線蟲存活率	76
第五章 結論與未來建議	79
第六章 參考文獻	80
                                    

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