約在十九世紀末，硫酸鈣就已經應用在醫療做為填補骨缺陷用途，由於硫酸鈣在人體內具有良好的生物相容性、不易引起併發症等優點，所以硫酸鈣被大量應用於骨取代物，不過與鈣磷系鈣基骨泥相比，硫酸鈣鈣基骨泥在生物體內的生物降解性太快，植入人體後太快被吸收。相較於先前學長的硫酸鈣混合磷酸鈣粉體的鈣基骨泥研究，本實驗以H粉為原料，混合P粉溶液，合成出含有氫氧基磷灰石(hydroxyapatite)的硫酸鈣/磷酸鈣複合骨泥粉體，控制四種合成時間(t1、t2、t3、t4)以獲得不同含量的硫酸鈣/磷酸鈣複合物，期望藉由降解速度慢的氫氧基磷灰石減緩整體骨取代物在生物體內的降解速度，進而製造出降解速度緩慢又有良好操作性質、崩解性質、注射性質的硫酸鈣複合磷酸鈣鈣基骨泥。
本實驗以抗壓強度、重量損失、孔隙率、pH值、鈣基骨泥的工作時間及硬化時間、注射性、崩解性、SEM試片表面分析及XRD成分分析來測試各項合成時間的性質，以找出最適合的骨取代物參數。

Summary
In nineteenth century, the calcium sulfate had been used in medical application to fill bone defect. Calcium sulfate has good biocompatibility in human body. When it is implanted in the human body , there will be not the phenomenon of hypercalcemia syndrome, complications, and even without any infection. But the drawback is that calcium sulfate degrades rapidly in vivo , in other words , it will soon be absorbed rapidly. In this study, calcium sulfate dehydrate will be mixed with diammonium hydrogen phosphate solution synthesize HA powder. Control the synthesis time, in order to get the different proportion powder with calcium sulfate and calcium phosphate. Expect by mixing the calcium phosphate powder to reduce the degradation rate. And then we can fabricate a calcium sulfate bone cement that has appropriate degradation rate, handleability, and injectability.
Key words: calcium sulfate cement, calcium phosphate cement
Introduction
In early stage, the bone defect was filled by autogenous bone graft or allografts. Most of the autogenous bone graft was got from iliac or ribs, but the disadvantage is that it will increase the risk of the surgery. Alloplasty do not have this problem ,so it is the tendency in the future.
Calcium phosphate and calcium sulfate are two typical such bioresorbable materials, calcium sulfate has become one of the most promising bone substitute materials today, because it has many advantage ,such as bioresorbable, , osteoconductivity and biocompatibility. But the disvantage of the calcium sulfate is that it has high rates of dissolution. High dissolution rate may not allow new bone cells to effectively grow into a bone cavity, so in this study will devote to investigate whether a calcium phosphate/calcium sulfate composite will lower the dissolution rate or not.

Materials and Methods
• The powders were made from the materials and chemicals listed in Table 3-1-1-1. And then use the powder to test compressive strength , weight loss , porosity , pH , working time , setting time , injectability , disintegrating , SEM and XRD to find an suitable synthesis arameter.

Result and Discussion
All powders with different soaking time have the good injectability. In weight loss test, the samples with pressure of 0.7Mpa have higher compressive strength then pressureless samples. The high concentration of setting solution (C2M) also has higher compressive strength then low concentration of setting solution (C1M) . In porosity test, no mater the different concentration setting solution, the porosity will not change, it will maintain 50%~60%. The pH value will increase with increasing immersing time. Compare the XRD analysis, the powder with longer soaking time has a higher intensity of calcium phosphate and lower intensity of calcium sulfate than the powder with shorter soaking time. Compare the SEM analysis, the powder with longer soaking time has more calcium phosphate granue than the powder with shorter soaking time. And the surface of ocylindrical will be smooth when adding the high concentration of setting solution (C2M).

Conclusion
(1) Compare the compressive strength and weight loss, when the concentration of setting liquid is C2M and the soaking time is t2, it will has the highest compressive strength and the lowest weight loss in day 14.
(2) The working time, pH value, injectability and dispersion do not have obviously different with different concentration setting liquid and different soaking time.

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